desmopressin [Ligand Id: 2182] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL264448
  • V1A receptor in Human [GtoPdb: 366] [UniProtKB: P37288]
  • V1A receptor in Rat [GtoPdb: 366] [UniProtKB: P30560]
  • 5.6
1 CHEMBL264448_lig_chart_1 V1A receptor HumanRat
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  • V1B receptor in Human [GtoPdb: 367] [UniProtKB: P47901]
  • V1B receptor in Rat [GtoPdb: 367] [UniProtKB: P48974]
  • 8
2 CHEMBL264448_lig_chart_2 V1B receptor HumanRat
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  • V2 receptor in Human [GtoPdb: 368] [UniProtKB: P30518]
  • V2 receptor in Rat [GtoPdb: 368] [UniProtKB: Q00788]
  • 8.7
3 CHEMBL264448_lig_chart_3 V2 receptor HumanRat
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  • OT receptor in Human [GtoPdb: 369] [UniProtKB: P30559]
  • This target only has 1 pki data point
  • 7.6
4 CHEMBL264448_lig_chart_4 OT receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
V1A receptor in Human [GtoPdb: 366] [UniProtKB: P37288]
GtoPdb - - 7.7 pKi - - - Br J Pharmacol (1998) 125: 1463-70 [PMID:9884074];
J Biol Chem (1997) 272: 26536-44 [PMID:9334232];
Br J Pharmacol (2000) 129: 1700-6 [PMID:10780976];
Endocrinology (1997) 138: 4109-22 [PMID:9322919];
J Med Chem (2004) 47: 2375-2388 [PMID:15084136];
Biochem Pharmacol (1997) 53: 1711-1717 [PMID:9264324]
V1A receptor in Rat [GtoPdb: 366] [UniProtKB: P30560]
GtoPdb - - 5.6 pKi - - - EMBO J (1995) 14: 2176-82 [PMID:7774575]
V1B receptor in Human [GtoPdb: 367] [UniProtKB: P47901]
GtoPdb - - 8.2 pKi - - - Br J Pharmacol (2000) 129: 1700-6 [PMID:10780976];
Endocrinology (1997) 138: 4109-22 [PMID:9322919];
J Med Chem (2004) 47: 2375-2388 [PMID:15084136];
Biochem Pharmacol (1997) 53: 1711-1717 [PMID:9264324]
V1B receptor in Rat [GtoPdb: 367] [UniProtKB: P48974]
GtoPdb - - 8 pKi - - - Biochem Pharmacol (1997) 53: 1711-1717 [PMID:9264324]
V2 receptor in Human [GtoPdb: 368] [UniProtKB: P30518]
GtoPdb - - 8.6 pKi 2.5 nM Ki J Med Chem (2004) 47: 2375-2388 [PMID:15084136];
EMBO J (1995) 14: 2176-82 [PMID:7774575];
J Biol Chem (1998) 273: 29462-8 [PMID:9792651];
Br J Pharmacol (2000) 129: 1700-6 [PMID:10780976];
Biochem Pharmacol (1997) 53: 1711-1717 [PMID:9264324];
Kidney Int (2000) 58: 1613-22 [PMID:11012895];
Br J Pharmacol (1998) 125: 1463-70 [PMID:9884074];
Endocrinology (1997) 138: 4109-22 [PMID:9322919]
V2 receptor in Rat [GtoPdb: 368] [UniProtKB: Q00788]
GtoPdb - - 8.7 pKi - - - J Biol Chem (1998) 273: 29462-8 [PMID:9792651]
OT receptor in Human [GtoPdb: 369] [UniProtKB: P30559]
GtoPdb - - 7.6 pKi - - - EMBO J (1995) 14: 2176-82 [PMID:7774575];
Life Sci (1995) 57: 2253-61 [PMID:7475979]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]