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ChEMBL ligand: CHEMBL69091 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276] | ||||||||
ChEMBL | Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptor | B | 5.02 | pKd | 9530 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Inhibition of [3H]ATRA binding to baculovirus expressed retinoic acid receptor RAR-alpha | B | 5.02 | pKd | 9500 | nM | Kd | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
ChEMBL | Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptor | B | 6.25 | pKd | 556 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor alpha using transactivation assay | B | 6 | pEC50 | >1000 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor alpha using transactivation assay | B | 6 | pEC50 | >1000 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
Retinoic acid receptor-β/Retinoic acid receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826] | ||||||||
ChEMBL | Inhibition of [3H]ATRA binding to baculovirus expressed retinoic acid receptor RAR-beta | B | 4.69 | pKd | 20500 | nM | Kd | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
ChEMBL | Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptor | B | 4.69 | pKd | 20472 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptor | B | 6 | pKd | >1000 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation assay | B | 6 | pEC50 | >1000 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation assay | B | 6.47 | pEC50 | 340 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631] | ||||||||
ChEMBL | Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptor | B | 4.8 | pKd | 15942 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Inhibition of [3H]ATRA binding to baculovirus expressed retinoic acid receptor RAR-gamma | B | 4.8 | pKd | 15900 | nM | Kd | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
ChEMBL | Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptor | B | 6 | pKd | >1000 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay | B | 6 | pEC50 | >1000 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay | B | 6.7 | pEC50 | 200 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
Retinoid X receptor-α/Retinoid X receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793] | ||||||||
ChEMBL | Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptor | B | 6 | pKd | >1000 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-alpha | B | 8.82 | pKd | 1.5 | nM | Kd | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
ChEMBL | Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptor | B | 8.82 | pKd | 1.5 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
GtoPdb | - | - | 9.4 | pIC50 | - | - | - | J Med Chem (2001) 44: 2298-303 [PMID:11428923] |
ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation assay | B | 6 | pEC50 | >1000 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation assay | B | 8.82 | pEC50 | 1.5 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
Retinoid X receptor-β/Retinoid X receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1870] [GtoPdb: 611] [UniProtKB: P28702] | ||||||||
ChEMBL | Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]9-cis-RA as a radioligand in baculovirus expressed receptor | B | 6 | pKd | >1000 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-beta | B | 8.6 | pKd | 2.5 | nM | Kd | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
ChEMBL | Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]9-cis-RA as a radioligand in baculovirus expressed receptor | B | 8.6 | pKd | 2.5 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor beta using transactivation assay | B | 6 | pEC50 | >1000 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor beta using transactivation assay | B | 8.7 | pEC50 | 2 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
Retinoid X receptor-β in Mouse [GtoPdb: 611] [UniProtKB: P28704] | ||||||||
GtoPdb | - | - | 8.44 | pIC50 | - | - | - | J Med Chem (2001) 44: 2298-303 [PMID:11428923] |
Retinoid X receptor-γ/Retinoid X receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2004] [GtoPdb: 612] [UniProtKB: P48443] | ||||||||
ChEMBL | Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]9-cis-RA as a radioligand in baculovirus expressed receptor | B | 6 | pKd | >1000 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-gamma | B | 8.74 | pKd | 1.8 | nM | Kd | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
ChEMBL | Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]9-cis-RA as a radioligand in baculovirus expressed receptor | B | 8.74 | pKd | 1.8 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor gamma using transactivation assay | B | 6 | pEC50 | >1000 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor gamma using transactivation assay | B | 9 | pEC50 | 1 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]