tranilast [Ligand Id: 6326] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL415324 (MK-341, NSC-758970, Rizaben, Tranilast)
  • H-PGDS/Hematopoietic prostaglandin D synthase in Human [ChEMBL: CHEMBL5879] [GtoPdb: 1381] [UniProtKB: O60760]
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  • TRPV2/Transient receptor potential cation channel subfamily V member 2 in Human [ChEMBL: CHEMBL5051] [GtoPdb: 508] [UniProtKB: Q9Y5S1]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
H-PGDS/Hematopoietic prostaglandin D synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5879] [GtoPdb: 1381] [UniProtKB: O60760]
ChEMBL Inhibition of glutathione-S-transferase activity of prostaglandin D2 synthase B 4.94 pIC50 11600 nM IC50 J Med Chem (2008) 51: 2178-2186 [PMID:18341273]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay F 4.9 pIC50 12589.25 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay F 5.1 pIC50 7943.28 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
TRPV2/Transient receptor potential cation channel subfamily V member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5051] [GtoPdb: 508] [UniProtKB: Q9Y5S1]
GtoPdb - - 5 pIC50 10000 nM IC50 Cell Calcium (1997) 22: 75-82 [PMID:9292225]
ChEMBL Antagonist activity at TRPV2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2019) 62: 1373-1384 [PMID:30620187]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]