nicotine [Ligand Id: 2585] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3 (Prostep, Nicotrol NS, Nicoderm, Nicotinell support, Niquitin minis mint, Nicotinell tts 10, Niquitin minis cherry, Niquitin minis orange, Nicotrol, Niquitin pre-quit, Stubit, Nicorette invisi, Nicotrol Inhaler, Nicotine, Niquitin strips mint, Habitrol, Nicotinell classic, Nicopatch, Nicoderm cq, Nicopass, Niquitin, Nicabate, Nicotinell tts 30, Niquitin clr, Niquitin mint, Stoppers, Nicotinell tts 20)
  • Acetylcholine-binding protein in Lymnaea stagnalis [ChEMBL: CHEMBL6084] [UniProtKB: P58154]
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  • nicotinic acetylcholine receptor α1 subunit/nicotinic acetylcholine receptor γ subunit/nicotinic acetylcholine receptor β1 subunit/nicotinic acetylcholine receptor δ subunit/Acetylcholine receptor; alpha1/beta1/delta/gamma in Human [ChEMBL: CHEMBL1907588] [GtoPdb: 462475471476] [UniProtKB: P02708P07510P11230Q07001]
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  • Acetylcholine receptor protein alpha chain in Torpedo californica [ChEMBL: CHEMBL3097] [UniProtKB: P02710]
  • nicotinic acetylcholine receptor α1 subunit/Acetylcholine receptor protein alpha chain in Human [ChEMBL: CHEMBL4808] [GtoPdb: 462] [UniProtKB: P02708]
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  • Acetylcholine receptor subunit beta-like 2 in Drosophila melanogaster [ChEMBL: CHEMBL2366470] [UniProtKB: P25162]
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  • nicotinic acetylcholine receptor α1 subunit/nicotinic acetylcholine receptor γ subunit/nicotinic acetylcholine receptor β1 subunit/nicotinic acetylcholine receptor ε subunit/nicotinic acetylcholine receptor δ subunit/Muscle-type nicotinic acetylcholine receptor in Human [ChEMBL: CHEMBL2362997] [GtoPdb: 462475471477476] [UniProtKB: P02708P07510P11230Q04844Q07001]
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  • nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor α2 subunit/nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor β3 subunit/nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α5 subunit/nicotinic acetylcholine receptor α6 subunit/nicotinic acetylcholine receptor α9 subunit/nicotinic acetylcholine receptor α7 subunit/nicotinic acetylcholine receptor α10 subunit in Human [GtoPdb: 464465463472473474466467469468470] [UniProtKB: P32297P43681Q15822P17787Q05901P30926P30532Q15825Q9UGM1P36544Q9GZZ6]
  • nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor α2 subunit/nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor β3 subunit/nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α5 subunit/nicotinic acetylcholine receptor α6 subunit/nicotinic acetylcholine receptor α9 subunit/nicotinic acetylcholine receptor α7 subunit/nicotinic acetylcholine receptor α10 subunit/Neuronal acetylcholine receptor in Rat [ChEMBL: CHEMBL2094110] [GtoPdb: 464465463472473474466467469468470] [UniProtKB: P04757P09483P12389P12390P12391P12392P20420P43143P43144Q05941Q9JLB5]
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  • nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α2 subunit/Neuronal acetylcholine receptor; alpha2/beta2 in Human [ChEMBL: CHEMBL2109236] [GtoPdb: 472463] [UniProtKB: P17787Q15822]
  • nicotinic acetylcholine receptor α2 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha2/beta2 in Rat [ChEMBL: CHEMBL1907592] [GtoPdb: 463472] [UniProtKB: P12389P12390]
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  • nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α2 subunit/Neuronal acetylcholine receptor; alpha2/beta4 in Human [ChEMBL: CHEMBL2109230] [GtoPdb: 474463] [UniProtKB: P30926Q15822]
  • nicotinic acetylcholine receptor α2 subunit/nicotinic acetylcholine receptor β4 subunit/Neuronal acetylcholine receptor; alpha2/beta4 in Rat [ChEMBL: CHEMBL1907590] [GtoPdb: 463474] [UniProtKB: P12389P12392]
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  • nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor β3 subunit/nicotinic acetylcholine receptor α6 subunit/Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 in Human [ChEMBL: CHEMBL2109233] [GtoPdb: 472464473467] [UniProtKB: P17787P32297Q05901Q15825]
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  • nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α3 subunit/Neuronal acetylcholine receptor; alpha3/beta2 in Human [ChEMBL: CHEMBL2109234] [GtoPdb: 472464] [UniProtKB: P17787P32297]
  • nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha3/beta2 in Rat [ChEMBL: CHEMBL1907587] [GtoPdb: 464472] [UniProtKB: P04757P12390]
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  • nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α3 subunit/Neuronal acetylcholine receptor; alpha3/beta4 in Human [ChEMBL: CHEMBL1907594] [GtoPdb: 474464] [UniProtKB: P30926P32297]
  • nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor β4 subunit/Neuronal acetylcholine receptor; alpha3/beta4 in Rat [ChEMBL: CHEMBL1907593] [GtoPdb: 464474] [UniProtKB: P04757P12392]
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  • nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human [ChEMBL: CHEMBL1907589] [GtoPdb: 472465] [UniProtKB: P17787P43681]
  • nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Rat [ChEMBL: CHEMBL1907596] [GtoPdb: 465472] [UniProtKB: P09483P12390]
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  • nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta4 in Human [ChEMBL: CHEMBL1907591] [GtoPdb: 474465] [UniProtKB: P30926P43681]
  • nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β4 subunit/Neuronal acetylcholine receptor; alpha4/beta4 in Rat [ChEMBL: CHEMBL1907595] [GtoPdb: 465474] [UniProtKB: P09483P12392]
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  • nicotinic acetylcholine receptor α2 subunit/Neuronal acetylcholine receptor protein alpha-2 subunit in Rat [ChEMBL: CHEMBL2584] [GtoPdb: 463] [UniProtKB: P12389]
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  • nicotinic acetylcholine receptor α4 subunit in Human [GtoPdb: 465] [UniProtKB: P43681]
  • nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor protein alpha-4 subunit in Mouse [ChEMBL: CHEMBL4457] [GtoPdb: 465] [UniProtKB: O70174]
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  • nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544]
  • nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Mouse [ChEMBL: CHEMBL3365] [GtoPdb: 468] [UniProtKB: P49582]
  • nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Rat [ChEMBL: CHEMBL4980] [GtoPdb: 468] [UniProtKB: Q05941]
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  • nicotinic acetylcholine receptor α9 subunit/Neuronal acetylcholine receptor protein alpha-9 subunit in Rat [ChEMBL: CHEMBL2585] [GtoPdb: 469] [UniProtKB: P43144]
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  • nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α5 subunit/nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α3 subunit/Neuronal acetylcholine receptors; alpha-3/beta-4, alpha-5, beta-2 in Human [ChEMBL: CHEMBL2221346] [GtoPdb: 472466474464] [UniProtKB: P17787P30532P30926P32297]
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  • nicotinic acetylcholine receptor α3 subunit/Neuronal acetylcholine receptor subunit alpha-3 in Human [ChEMBL: CHEMBL3068] [GtoPdb: 464] [UniProtKB: P32297]
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  • nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α3 subunit in Human [GtoPdb: 474464] [UniProtKB: P30926P32297]
  • nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α3 subunit/Neuronal acetylcholine receptor subunit alpha-3/beta-4 in Mouse [ChEMBL: CHEMBL3885609] [GtoPdb: 474464] [UniProtKB: Q8R493Q8R4G9]
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  • Neuronal acetylcholine receptor subunit alpha-4 in Chicken [ChEMBL: CHEMBL5569] [UniProtKB: P09482]
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  • nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β2 subunit in Human [GtoPdb: 465472] [UniProtKB: P43681P17787]
  • nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor subunit alpha-4/beta-2 in Mouse [ChEMBL: CHEMBL3883314] [GtoPdb: 465472] [UniProtKB: O70174Q9ERK7]
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  • nicotinic acetylcholine receptor β3 subunit/nicotinic acetylcholine receptor α6 subunit/Neuronal acetylcholine receptor subunit alpha-6/beta-3 in Rat [ChEMBL: CHEMBL3883329] [GtoPdb: 473467] [UniProtKB: P12391P43143]
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  • nicotinic acetylcholine receptor β4 subunit/Neuronal acetylcholine receptor subunit beta-4 in Rat [ChEMBL: CHEMBL2658] [GtoPdb: 474] [UniProtKB: P12392]
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  • nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor α7 subunit/nicotinic acetylcholine receptor α5 subunit/nicotinic acetylcholine receptor β3 subunit/nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor α2 subunit/nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α6 subunit in Human [GtoPdb: 465468466473474464463472467] [UniProtKB: P43681P36544P30532Q05901P30926P32297Q15822P17787Q15825]
  • nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor α7 subunit/nicotinic acetylcholine receptor α5 subunit/nicotinic acetylcholine receptor β3 subunit/nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor α2 subunit/nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α6 subunit/Neuronal nicotinic acetylcholine receptor in Mouse [ChEMBL: CHEMBL3350222] [GtoPdb: 465468466473474464463472467] [UniProtKB: O70174P49582Q2MKA5Q8BMN3Q8R493Q8R4G9Q91X60Q9ERK7Q9R0W9]
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  • nicotinic acetylcholine receptor α1 subunit/nicotinic acetylcholine receptor β4 subunit/Nicotinic acetylcholine receptor alpha2/beta4 in Human [ChEMBL: CHEMBL3038459] [GtoPdb: 462474] [UniProtKB: P02708P30926]
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  • nicotinic acetylcholine receptor β1 subunit/nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor β3 subunit/Nicotinic acetylcholine receptor alpha3/betaX in Human [ChEMBL: CHEMBL2111384] [GtoPdb: 471472474464473] [UniProtKB: P11230P17787P30926P32297Q05901]
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  • nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor β2 subunit/Nicotinic acetylcholine receptor alpha-4/beta-2 in Mouse [ChEMBL: CHEMBL3301382] [GtoPdb: 474472] [UniProtKB: Q8R493Q9ERK7]
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  • Nicotinic acetylcholine receptor alpha 5 subunit in Musca domestica [ChEMBL: CHEMBL2366408] [UniProtKB: A9XFY4]
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
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  • Soluble acetylcholine receptor in Aplysia californica [ChEMBL: CHEMBL1944497] [UniProtKB: Q8WSF8]
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  • Organic cation transporter 1/Solute carrier family 22 member 1 in Rat [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089]
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  • Organic cation transporter 2/Solute carrier family 22 member 2 in Rat [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2]
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  • TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
  • TRPA1/Transient receptor potential cation channel subfamily A member 1 in Mouse [ChEMBL: CHEMBL1075310] [GtoPdb: 485] [UniProtKB: Q8BLA8]
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  • Kv4.3 in Rat [GtoPdb: 554] [UniProtKB: Q62897]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Acetylcholine-binding protein in Lymnaea stagnalis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6084] [UniProtKB: P58154]
ChEMBL Binding affinity to Lymnaea stagnalis His6-AChBP expressed in Bac-to-Bac baculovirus expression system by surface plasmon resonance biosensor assay B 6.32 pKd 478.63 nM Kd J. Med. Chem. (2010) 53: 7192-7201 [PMID:20828128]
ChEMBL Binding affinity to Lymnaea stagnalis AChBP after 300 seconds by SPR biosensor analysis B 6.49 pKd 320 nM Kd Eur. J. Med. Chem. (2015) 102: 425-444 [PMID:26301559]
ChEMBL Binding affinity to Lymnaea stagnalis AChBP after 300 seconds by SPR biosensor analysis B 6.5 pKd 316.23 nM Kd Eur. J. Med. Chem. (2015) 102: 425-444 [PMID:26301559]
ChEMBL Displacement of [3H]epibatidine from Lymnaea stagnalis AChBP B 6.3 pKi 496 nM Ki J. Med. Chem. (2012) 55: 8028-8037 [PMID:22928944]
ChEMBL Displacement of [3H]epibatidine from Lymnaea stagnalis His6-AChBP expressed in Bac-to-Bac baculovirus expression system B 6.48 pKi 331.13 nM Ki J. Med. Chem. (2010) 53: 7192-7201 [PMID:20828128]
ChEMBL Displacement of [3H]-epibatidine from histidine-tagged Lymnaea stagnalis AChBP expressed in Sf9 cells after 1.5 hrs by liquid scintillation counting B 6.5 pKi 316.23 nM Ki Bioorg. Med. Chem. (2011) 19: 6107-6119 [PMID:21920761]
ChEMBL Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine binding protein expressed using baculoviral system after 1.5 hrs by scintillation counting B 6.5 pKi 316.23 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 1448-1454 [PMID:22243960]
ChEMBL Binding affinity to freshwater snail Lymnaea stagnalis AChBP assessed as [3H]EPI binding by radioligand binding assay B 7 pKi 100 nM Ki J Agric Food Chem (2011) 59: 2825-2828 [PMID:21341671]
ChEMBL Displacement of [3H]epibatidine from Lymnaea stagnalis AChBP linked to ion channel portion of 5-HT3A receptor expressed in HEK293 cells after 4 hrs by scintillation counting analysis B 7.08 pKi 83.18 nM Ki J. Med. Chem. (2013) 56: 940-951 [PMID:23256554]
ChEMBL Displacement of [3H]epibatidine from Lymnaea stagnalis AChBP linked to ion channel portion of 5-HT3A receptor expressed in HEK293 cells after 4 hrs by scintillation counting analysis B 7.08 pKi 83 nM Ki J. Med. Chem. (2013) 56: 940-951 [PMID:23256554]
ChEMBL Displacement of [125I]alpha-bungarotoxin from Lymnaea stagnalis His-tagged AchBP B 7.2 pKi 63.1 nM Ki J. Med. Chem. (2009) 52: 2372-2383 [PMID:19331415]
Acetylcholine receptor in Torpedo californica (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096975] [UniProtKB: P02710P02712P02714P02718]
ChEMBL Binding potency for nAChR subtype Alpha-1-beta-1-delta-gamma (torpedo) B 5 pKi >10000 nM Ki J. Med. Chem. (1997) 40: 4169-4194 [PMID:9435889]
ChEMBL Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1 beta gamma delta of electroplax B 5.2 pKi 6270 nM Ki J. Med. Chem. (2005) 48: 3474-3477 [PMID:15887955]
ChEMBL inhibition of (-)-[3H]nicotine binding to torpedo electroplax membranes B 8.4 pIC50 4 nM IC50 J. Med. Chem. (1988) 31: 506-509 [PMID:3346870]
ChEMBL Inhibition of [3H]MCC binding to torpedo electroplax membranes B 9 pIC50 1 nM IC50 J. Med. Chem. (1988) 31: 506-509 [PMID:3346870]
ChEMBL Functional potency for nAChR subtype Alpha-1-beta-1-delta gamma(torpedo) B 4.22 pEC50 60000 nM EC50 J. Med. Chem. (1997) 40: 4169-4194 [PMID:9435889]
nicotinic acetylcholine receptor α1 subunit/nicotinic acetylcholine receptor γ subunit/nicotinic acetylcholine receptor β1 subunit/nicotinic acetylcholine receptor δ subunit/Acetylcholine receptor; alpha1/beta1/delta/gamma in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907588] [GtoPdb: 462475471476] [UniProtKB: P02708P07510P11230Q07001]
ChEMBL Binding affinity to human Nicotinic acetylcholine receptor alpha-1-beta-gamma-delta expressed in HEK 293 cells using [3H]alpha-bungarotoxin B 5.2 pKi 6270 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4889-4897 [PMID:16171993]
ChEMBL In vitro Binding affinity towards alpha-1-beta-1-gamma delta nAChR was determined B 5.26 pKi 5500 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 319-321 [PMID:11212100]
ChEMBL Binding affinity to alpha-1-beta-gamma-delta nicotinic receptor B 5.83 pKi 1480 nM Ki