Ro-32-0432

Ligand id: 6034

Name: Ro-32-0432

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 59.27
Molecular weight 452.22
XLogP 5.11
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Classification
Compound class Synthetic organic
IUPAC Name
3-[(2S)-2-[(dimethylamino)methyl]-1H,2H,3H,4H-pyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
Synonyms
Ro 32-0432 | Ro-320432
Comments
Ro-32-0432 is a cell-permeable selective inhibitor of protein kinase C (PKC).
Database Links
CAS Registry No. 151342-35-7
ChEMBL Ligand CHEMBL26501
GtoPdb PubChem SID 178102656
PubChem CID 127757
Search Google for chemical match using the InChIKey FXGHOAZJQNLNFD-KRWDZBQOSA-N
Search Google for chemicals with the same backbone FXGHOAZJQNLNFD
Search UniChem for chemical match using the InChIKey FXGHOAZJQNLNFD-KRWDZBQOSA-N
Search UniChem for chemicals with the same backbone FXGHOAZJQNLNFD