Ro-32-0432   Click here for help

GtoPdb Ligand ID: 6034

Synonyms: Ro 32-0432 | Ro-320432
Compound class: Synthetic organic
Comment: Ro-32-0432 is a cell-permeable selective inhibitor of protein kinase C (PKC).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 59.27
Molecular weight 452.22
XLogP 5.11
No. Lipinski's rules broken 1
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Canonical SMILES CN(CC1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1cn(c3c1cccc3)C)c1c2cccc1)C
Isomeric SMILES CN(C[C@H]1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1cn(c3c1cccc3)C)c1c2cccc1)C
InChI InChI=1S/C28H28N4O2/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34)/t17-/m0/s1

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
ribosomal protein S6 kinase A3 Rsk2/RSK2 Hs Inhibitor Inhibition 1.8
protein kinase C beta PKCβII/PKCb2 Hs Inhibitor Inhibition 2.3
protein kinase C alpha PKCα/PKCa Hs Inhibitor Inhibition 2.6
protein kinase C epsilon PKCε/PKCepsilon Hs Inhibitor Inhibition 2.7
ribosomal protein S6 kinase A6 Rsk4/RSK4 Hs Inhibitor Inhibition 2.9
ribosomal protein S6 kinase A2 Rsk3/RSK3 Hs Inhibitor Inhibition 3.6
protein kinase C beta PKCβI/PKCb1 Hs Inhibitor Inhibition 3.7
ribosomal protein S6 kinase A1 Rsk1/RSK1 Hs Inhibitor Inhibition 5.9
protein kinase C gamma PKCγ/PKCg Hs Inhibitor Inhibition 6.9
protein kinase N1 nd/PKN1(PRK1) Hs Inhibitor Inhibition 7.1
Displaying the top 10 targets  View all targets in screen »