ciclopirox [Ligand Id: 11349] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1413 (Ciclopirox, Cyclopirox, HOE 296B, HOE-296B, Loprox, Penlac)
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  • isocitrate dehydrogenase (NADP(+)) 1/Isocitrate dehydrogenase [NADP] cytoplasmic in Human [ChEMBL: CHEMBL2007625] [GtoPdb: 2884] [UniProtKB: O75874]
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  • poly(ADP-ribose) polymerase 1 in Human [GtoPdb: 2771] [UniProtKB: P09874]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Deoxyhypusine hydroxylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523441] [UniProtKB: Q9BU89]
ChEMBL Inhibition of DOHH (unknown origin) B 5.3 pIC50 5000 nM IC50 Eur J Med Chem (2019) 165: 172-197 [PMID:30684796]
isocitrate dehydrogenase (NADP(+)) 1/Isocitrate dehydrogenase [NADP] cytoplasmic in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007625] [GtoPdb: 2884] [UniProtKB: O75874]
ChEMBL Inhibition of human IDH1 R132H mutant expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumption B 4.3 pKi >50000 nM Ki J Med Chem (2014) 57: 8307-8318 [PMID:25271760]
poly(ADP-ribose) polymerase 1 in Human [GtoPdb: 2771] [UniProtKB: P09874]
GtoPdb - - 6.8 pIC50 160 nM IC50 Bioorg Med Chem Lett (2008) 18: 5126-9 [PMID:18713665]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]