[3H]nisoxetine [Ligand Id: 4636] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1628648 ([3H]-Nisoxetine)
  • NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL Binding affinity to human NET S225H mutant expressed in african green monkey COS1 cells B 6.18 pKd 656 nM Kd J Biol Chem (2007) 282: 17837-17844 [PMID:17428804]
ChEMBL Binding affinity to human NET T381K mutant expressed in african green monkey COS1 cells B 6.19 pKd 650 nM Kd J Biol Chem (2007) 282: 17837-17844 [PMID:17428804]
ChEMBL Binding affinity to human NET F207T mutant expressed in african green monkey COS1 cells B 6.5 pKd 319 nM Kd J Biol Chem (2007) 282: 17837-17844 [PMID:17428804]
ChEMBL Binding affinity to human NET H296S mutant expressed in african green monkey COS1 cells B 6.59 pKd 257 nM Kd J Biol Chem (2007) 282: 17837-17844 [PMID:17428804]
ChEMBL Binding affinity to human NET D473A mutant expressed in african green monkey COS1 cells B 7.33 pKd 47 nM Kd J Biol Chem (2007) 282: 17837-17844 [PMID:17428804]
ChEMBL Binding affinity to human wild type NET expressed in african green monkey COS1 cells B 8.29 pKd 5.1 nM Kd J Biol Chem (2007) 282: 17837-17844 [PMID:17428804]
GtoPdb - - 8.4 pKd 4 nM Kd

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]