ChEMBL ligand: CHEMBL396460 (Nociceptin, Nociceptin/orphanin FQ, Orphanin FQ)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
NOP receptor/Nociceptin receptor in Human [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146] NOP receptor/Nociceptin receptor in Mouse [ChEMBL: CHEMBL3621] [GtoPdb: 320] [UniProtKB: P35377] NOP receptor/Nociceptin receptor in Rat [ChEMBL: CHEMBL4503] [GtoPdb: 320] [UniProtKB: P35370] Nociceptin receptor in Guinea pig [ChEMBL: CHEMBL5492] [UniProtKB: P47748] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]naltrindole from human delta opioid receptor expressed in HEK293 cells	B	5	pKi	>10000	nM	Ki	J Med Chem (2008) 51: 1058-1062 [PMID:18232652]
ChEMBL	Binding affinity for opioid receptor type, human Opioid receptor delta 1 expressed in membrane homogenates of COS-1 or CHO cells	B	5.52	pKi	3000	nM	Ki	J Med Chem (2002) 45: 5353-5357 [PMID:12431062]
ChEMBL	Displacement of [3H]Cl-DPDPE from human DOP receptor expressed in CHO cells after 60 mins by scintillation counting	B	5.55	pKi	2846	nM	Ki	J Med Chem (2011) 54: 6531-6537 [PMID:21866885]
ChEMBL	Inhibition of [3H]naltrindole binding to human Opioid receptor delta 1	B	5.7	pKi	>2000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5045-5050 [PMID:15380196]
ChEMBL	Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHOK1 cells	B	6	pKi	>1000	nM	Ki	J Med Chem (2009) 52: 610-625 [PMID:19125610]
ChEMBL	Displacement of [3H]DPDPE from human DOP receptor expressed in CHO-K1 cells after 45 mins	B	6	pKi	>1000	nM	Ki	Bioorg Med Chem (2010) 18: 7675-7699 [PMID:20875743]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in HEK293 cells	B	5	pKi	>10000	nM	Ki	J Med Chem (2008) 51: 1058-1062 [PMID:18232652]
ChEMBL	Inhibition of [3H]U-69593 binding to human Opioid receptor kappa 1	B	5.7	pKi	>2000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5045-5050 [PMID:15380196]
ChEMBL	Binding affinity for opioid receptor type, human Opioid receptor kappa 1 expressed in membrane homogenates of COS-1 or CHO cells	B	5.82	pKi	1500	nM	Ki	J Med Chem (2002) 45: 5353-5357 [PMID:12431062]
ChEMBL	Displacement of [3H]enadoline from human kappa opioid receptor expressed in HEK293 cells	B	6	pKi	>1000	nM	Ki	J Med Chem (2009) 52: 610-625 [PMID:19125610]
ChEMBL	Displacement of [3H]enadoline from human KOP receptor expressed in HEK-293 cells after 45 mins	B	6	pKi	>1000	nM	Ki	Bioorg Med Chem (2010) 18: 7675-7699 [PMID:20875743]
ChEMBL	Displacement of [3H]U69593 from human KOP receptor expressed in CHO cells after 60 mins by scintillation counting	B	6.83	pKi	147	nM	Ki	J Med Chem (2011) 54: 6531-6537 [PMID:21866885]
ChEMBL	Partial agonist activity at human KOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting	F	7.11	pEC50	78.5	nM	EC50	J Med Chem (2011) 54: 6531-6537 [PMID:21866885]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cells	B	5.52	pKi	3030	nM	Ki	J Med Chem (2008) 51: 1058-1062 [PMID:18232652]
ChEMBL	Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells	B	6	pKi	>1000	nM	Ki	J Med Chem (2009) 52: 610-625 [PMID:19125610]
ChEMBL	Displacement of [3H]DAMGO from human MOP receptor expressed in CHO-K1 cells after 45 mins	B	6	pKi	>1000	nM	Ki	Bioorg Med Chem (2010) 18: 7675-7699 [PMID:20875743]
ChEMBL	Displacement of [3H]DAMGO from human MOP receptor expressed in CHO cells after 60 mins by scintillation counting	B	6.36	pKi	437	nM	Ki	J Med Chem (2011) 54: 6531-6537 [PMID:21866885]
ChEMBL	Binding affinity for opioid receptor type, human Opioid receptor mu 1 expressed in membrane homogenates of COS-1 or CHO cells	B	6.57	pKi	270	nM	Ki	J Med Chem (2002) 45: 5353-5357 [PMID:12431062]
NOP receptor/Nociceptin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146]
ChEMBL	Binding affinity to human ORL1 receptor expressed in African green monkey COS7 cells assessed per mg protein after 90 mins by Scatchard plot analysis	B	9.72	pKd	0.19	nM	Kd	Bioorg Med Chem (2014) 22: 5902-5909 [PMID:25284251]
ChEMBL	Binding affinity to recombinant ORL1 receptor expressed in COS7 cells by saturation binding assay	B	10.04	pKd	0.09	nM	Kd	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Displacement of radiolabeled nociceptin from human ORL1 receptor	B	9.26	pKi	0.55	nM	Ki	J Med Chem (2008) 51: 7094-7098 [PMID:18983139]
ChEMBL	Binding affinity to human NOP receptor by radioligand displacement assay	B	9.32	pKi	0.48	nM	Ki	Eur J Med Chem (2013) 63: 85-94 [PMID:23466604]
ChEMBL	Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 mins	B	9.41	pKi	0.39	nM	Ki	Bioorg Med Chem (2010) 18: 7675-7699 [PMID:20875743]
ChEMBL	Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells	B	9.41	pKi	0.39	nM	Ki	J Med Chem (2009) 52: 610-625 [PMID:19125610]
ChEMBL	Displacement of [3H]N/OFQ from human recombinant NOP receptor expressed in CHO cells	B	9.5	pKi	0.32	nM	Ki	Bioorg Med Chem (2007) 15: 4434-4443 [PMID:17490886]
ChEMBL	Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cells	B	9.52	pKi	0.3	nM	Ki	J Med Chem (2002) 45: 5280-5286 [PMID:12431054]
ChEMBL	Displacement of [3H]-nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by scintillation counting	B	9.67	pKi	0.21	nM	Ki	J Med Chem (2014) 57: 3418-3429 [PMID:24678969]
ChEMBL	Inhibition of [3H]nociceptin binding to human Opioid receptor like 1	B	9.74	pKi	0.18	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5045-5050 [PMID:15380196]
ChEMBL	Displacement of [125I]Tyr14-nociceptin from human NOP receptor expressed in HEK293 cells	B	9.89	pKi	0.13	nM	Ki	J Med Chem (2008) 51: 1058-1062 [PMID:18232652]
ChEMBL	Displacement of [3H]N/OFQ from human nociceptin opioid receptor transfected in CHO cell membranes	B	9.92	pKi	0.12	nM	Ki	Bioorg Med Chem (2014) 22: 2508-2516 [PMID:24657054]
ChEMBL	Binding affinity for opioid receptor like type, human Opioid receptor like 1 expressed in membrane homogenates of COS-1 or CHO cells	B	10	pKi	0.1	nM	Ki	J Med Chem (2002) 45: 5353-5357 [PMID:12431062]
ChEMBL	Displacement of [3H]N/OFQ from human NOP receptor expressed in CHO cells after 60 mins by scintillation counting	B	10.1	pKi	0.08	nM	Ki	J Med Chem (2011) 54: 6531-6537 [PMID:21866885]
ChEMBL	Binding affinity for human nociceptin (NOP) receptor using [3H]N/OFQ as radioligand transfected into CHO cells	B	10.22	pKi	0.06	nM	Ki	Bioorg Med Chem Lett (2004) 14: 181-185 [PMID:14684324]
ChEMBL	Binding affinity for recombinant human N/OFQ peptide receptor (NOP) expressed in chinese hamster ovary cells	B	10.31	pKi	0.05	nM	Ki	J Med Chem (2005) 48: 1421-1427 [PMID:15743186]
GtoPdb	-	-	10.4	pKi	-	-	-	Br J Pharmacol (1999) 127: 123-30 [PMID:10369464]; Naunyn Schmiedebergs Arch Pharmacol (2002) 365: 442-9 [PMID:12070757]; Neuropeptides (1997) 31: 403-8 [PMID:9413015]
ChEMBL	Inhibition of human ORL1 receptor	B	8.68	pIC50	2.1	nM	IC50	J Med Chem (2008) 51: 4150-4169 [PMID:18588282]
ChEMBL	Displacement of [3H]]isoVa-RYYRIK-NH2 from human ORL1 receptor low affinity binding site expressed in African green monkey COS7 cells after 90 mins by topcount analysis	B	8.74	pIC50	1.83	nM	IC50	Bioorg Med Chem (2014) 22: 5902-5909 [PMID:25284251]
ChEMBL	Displacement of radiolabeled nociceptin from human ORL1 receptor	B	8.77	pIC50	1.7	nM	IC50	J Med Chem (2008) 51: 7094-7098 [PMID:18983139]
ChEMBL	Binding affinity to human NOP receptor by radioligand displacement assay	B	8.82	pIC50	1.5	nM	IC50	Eur J Med Chem (2013) 63: 85-94 [PMID:23466604]
ChEMBL	Displacement of [3H]nociceptin from human recombinant Nociceptin receptor expressed in HEK293 cells	B	8.89	pIC50	1.3	nM	IC50	Bioorg Med Chem (2016) 24: 1793-1810 [PMID:26988801]
ChEMBL	Displacement of [3H]nociceptin from recombinant ORL1 receptor expressed in COS7 cells by competitive receptor binding assay	B	9.14	pIC50	0.72	nM	IC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Displacement of [3H]]nociceptin from human ORL1 receptor expressed in African green monkey COS7 cells after 90 mins by topcount analysis	B	9.19	pIC50	0.65	nM	IC50	Bioorg Med Chem (2014) 22: 5902-5909 [PMID:25284251]
ChEMBL	Displacement of [3H]nociceptin from human ORL1-Galpha fusion receptor in COS7 cells	B	9.22	pIC50	0.6	nM	IC50	Bioorg Med Chem (2008) 16: 2635-2644 [PMID:18068993]
ChEMBL	Binding affinity to ORL1 receptor (unknown origin) by radioligand displacement assay	B	9.54	pIC50	0.29	nM	IC50	Bioorg Med Chem (2013) 21: 2764-2771 [PMID:23582449]
ChEMBL	Displacement of [3H]nociceptin from recombinant ORL1 receptor expressed in COS7 cells by competitive receptor binding assay	B	9.68	pIC50	0.21	nM	IC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Displacement of [3H]]isoVa-RYYRIK-NH2 from human ORL1 receptor high affinity binding site expressed in African green monkey COS7 cells after 90 mins by topcount analysis	B	10.08	pIC50	0.08	nM	IC50	Bioorg Med Chem (2014) 22: 5902-5909 [PMID:25284251]
ChEMBL	Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay	B	7.2	pEC50	63	nM	EC50	J Med Chem (2000) 43: 1329-1338 [PMID:10753470]
ChEMBL	Stimulation of [35S]GTP-gamma-S, binding against human Opioid receptor like 1	F	7.62	pEC50	24	nM	EC50	J Med Chem (2002) 45: 5353-5357 [PMID:12431062]
ChEMBL	Agonist activity at recombinant ORL1 receptor expressed in COS7 cells assessed as stimulation of GTPgammaS binding	F	7.89	pEC50	13	nM	EC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Partial agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting	F	8.09	pEC50	8.1	nM	EC50	J Med Chem (2011) 54: 6531-6537 [PMID:21866885]
ChEMBL	Activity at human ORL1-Galpha fusion receptor in COS7 cells assessed as stimulation of [35S]GTP-gamma-S binding	F	8.41	pEC50	3.91	nM	EC50	Bioorg Med Chem (2008) 16: 2635-2644 [PMID:18068993]
ChEMBL	Agonist activity at human nociceptin opioid receptor transfected in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	F	8.44	pEC50	3.6	nM	EC50	Bioorg Med Chem (2014) 22: 2508-2516 [PMID:24657054]
ChEMBL	Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS binding	F	8.82	pEC50	1.5	nM	EC50	J Med Chem (2009) 52: 610-625 [PMID:19125610]
ChEMBL	Agonist activity at human NOP receptor expressed in HEK293 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting	F	8.82	pEC50	1.5	nM	EC50	Bioorg Med Chem (2010) 18: 7675-7699 [PMID:20875743]
ChEMBL	Agonist activity at recombinant ORL1 receptor expressed in COS7 cells assessed as stimulation of GTPgammaS binding	F	8.96	pEC50	1.1	nM	EC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)	B	8.98	pEC50	1.05	nM	EC50	J Med Chem (2005) 48: 1421-1427 [PMID:15743186]
ChEMBL	Agonist activity at human NOP receptor expressed in CHO cells by [35S]GTPgammaS binding assay	F	9.04	pEC50	0.91	nM	EC50	Bioorg Med Chem (2007) 15: 4434-4443 [PMID:17490886]
ChEMBL	Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cells	B	9.35	pEC50	0.45	nM	EC50	J Med Chem (2002) 45: 5280-5286 [PMID:12431054]
ChEMBL	Agonist activity at human NOP receptor expressed in CHO cells assessed as dynamic mass redistribution by DMR assay	F	9.37	pEC50	0.43	nM	EC50	J Med Chem (2021) 64: 6656-6669 [PMID:33998786]
ChEMBL	Antagonist activity at human recombinant NOP receptor expressed in CHO cells coexpressing alphaqi5 assessed as inhibition of N/OFQ-induced intracellular calcium mobilization	F	9.41	pEC50	0.39	nM	EC50	J Med Chem (2009) 52: 4068-4071 [PMID:19473027]
ChEMBL	Agonist activity at human nociceptin receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production preincubated for 15 mins followed by forskolin addition measured for 90 mins by luciferase reporter gene assay	F	9.64	pEC50	0.23	nM	EC50	J Med Chem (2016) 59: 3777-3792 [PMID:27035422]
ChEMBL	Agonist activity at human recombinant NOP receptor expressed in CHO cells co-expressing C-terminally modifed Gaqi5 protein by Fluo-4AM dye based calcium mobilization assay	F	9.68	pEC50	0.21	nM	EC50	Medchemcomm (2014) 5: 973-983
GtoPdb	-	-	9.8	pEC50	-	-	-	J Pharmacol Exp Ther (1997) 283: 735-41 [PMID:9353393]
ChEMBL	Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)	F	9.94	pEC50	0.11	nM	EC50	J Med Chem (2005) 48: 1421-1427 [PMID:15743186]
ChEMBL	Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor like 1	F	10.05	pEC50	0.09	nM	EC50	Bioorg Med Chem Lett (2004) 14: 5045-5050 [PMID:15380196]
ChEMBL	Compound was evaluated for increase in [35S]GTP-gamma-S, binding for human ORL1 receptor carried out in CHO cell membranes; Nd: no data	F	10.1	pEC50	0.08	nM	EC50	Bioorg Med Chem Lett (2002) 12: 3157-3160 [PMID:12372523]
NOP receptor/Nociceptin receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621] [GtoPdb: 320] [UniProtKB: P35377]
GtoPdb	-	-	9.4	pKi	-	-	-	J Pharmacol Exp Ther (1997) 283: 735-41 [PMID:9353393]
ChEMBL	Agonist activity at NOP receptor in Swiss mouse vas deferens by [35S]GTP-gamma-S binding assay	F	7.45	pEC50	35.48	nM	EC50	Bioorg Med Chem (2007) 15: 4434-4443 [PMID:17490886]
ChEMBL	Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phosphorylation after 30 mins post dose by Alphascreen Surefire assay	F	7.94	pEC50	11.48	nM	EC50	J Med Chem (2010) 53: 8400-8408 [PMID:21067234]
ChEMBL	Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phosphorylation after 30 mins post dose by Alphascreen Surefire assay	F	7.96	pEC50	11	nM	EC50	J Med Chem (2010) 53: 8400-8408 [PMID:21067234]
ChEMBL	Inhibition of electrically evoked contraction of mouse vas deferens	F	8.27	pEC50	5.37	nM	EC50	J Med Chem (2005) 48: 1421-1427 [PMID:15743186]
NOP receptor/Nociceptin receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4503] [GtoPdb: 320] [UniProtKB: P35370]
ChEMBL	Binding affinity to recombinant ORL1 receptor Tyr207Ala mutant expressed in COS7 cells by saturation binding assay	B	9.15	pKd	0.71	nM	Kd	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Binding affinity to recombinant ORL1 receptor Asp206Ala mutant expressed in COS7 cells by saturation binding assay	B	9.17	pKd	0.67	nM	Kd	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Binding affinity to recombinant ORL1 receptor Trp208Ala mutant expressed in COS7 cells by saturation binding assay	B	9.31	pKd	0.49	nM	Kd	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Compound was tested for inhibition against binding of radioligand [leucyl-3H]-OFQ to membrane of human embryonic kidney 293 cells overexpressing rat Opioid receptor like 1	B	10	pKd	0.1	nM	Kd	Bioorg Med Chem Lett (2000) 10: 831-834 [PMID:10782696]
ChEMBL	Binding affinity to recombinant ORL1 receptor Gln205Ala mutant expressed in COS7 cells by saturation binding assay	B	10.06	pKd	0.09	nM	Kd	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Displacement of [3H]nociceptin from recombinant ORL1 receptor Asp206Ala mutant expressed in COS7 cells by competitive receptor binding assay	B	8.99	pIC50	1.02	nM	IC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Displacement of [3H]nociceptin from recombinant ORL1 receptor Tyr207Ala mutant expressed in COS7 cells by competitive receptor binding assay	B	9.04	pIC50	0.91	nM	IC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Displacement of [3H]nociceptin from recombinant ORL1 receptor Trp208Ala mutant expressed in COS7 cells by competitive receptor binding assay	B	9.1	pIC50	0.8	nM	IC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Displacement of [3H]nociceptin from rat ORL1 receptor expressed in african green monkey COS7 cells	B	9.14	pIC50	0.73	nM	IC50	Bioorg Med Chem (2008) 16: 9261-9267 [PMID:18818087]
ChEMBL	Displacement of [3H]nociceptin from recombinant ORL1 receptor Gln205Ala mutant expressed in COS7 cells by competitive receptor binding assay	B	9.19	pIC50	0.65	nM	IC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Displacement of [3H]nociceptin from recombinant ORL1 receptor Asp206Ala mutant expressed in COS7 cells by competitive receptor binding assay	B	9.27	pIC50	0.54	nM	IC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Displacement of [3H]nociceptin from recombinant ORL1 receptor Tyr207Ala mutant expressed in COS7 cells by competitive receptor binding assay	B	9.34	pIC50	0.46	nM	IC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Displacement of [3H]nociceptin from recombinant ORL1 receptor Gln205Ala mutant expressed in COS7 cells by competitive receptor binding assay	B	9.66	pIC50	0.22	nM	IC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Displacement of [3H]nociceptin from recombinant ORL1 receptor Trp208Ala mutant expressed in COS7 cells by competitive receptor binding assay	B	9.66	pIC50	0.22	nM	IC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Agonist activity at NOP receptor in Sprague-Dawley rat vas deferens assessed as effect on electrically stimulated contractions	F	6.83	pEC50	147.91	nM	EC50	Bioorg Med Chem (2007) 15: 4434-4443 [PMID:17490886]
ChEMBL	pEC50 for its effect on stimulating GTPgammaS binding to membranes of HEK 293 cells overexpressing rat ORL-1 receptor	F	7.2	pEC50	63.1	nM	EC50	Bioorg Med Chem Lett (2000) 10: 831-834 [PMID:10782696]
ChEMBL	Agonist activity at recombinant ORL1 receptor Tyr207Ala mutant expressed in COS7 cells assessed as stimulation of GTPgammaS binding	F	7.6	pEC50	25	nM	EC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Agonist activity at recombinant ORL1 receptor Asp206Ala mutant expressed in COS7 cells assessed as stimulation of GTPgammaS binding	F	7.68	pEC50	21	nM	EC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Agonist activity at recombinant ORL1 receptor Gln205Ala mutant expressed in COS7 cells assessed as stimulation of GTPgammaS binding	F	7.89	pEC50	13	nM	EC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Activation of rat ORL1 receptor expressed in african green monkey COS7 cells by [35S]GTPgammaS binding assay	F	7.89	pEC50	13	nM	EC50	Bioorg Med Chem (2008) 16: 9261-9267 [PMID:18818087]
ChEMBL	Agonist activity at recombinant ORL1 receptor Asp206Ala mutant expressed in COS7 cells assessed as stimulation of GTPgammaS binding	F	8.25	pEC50	5.6	nM	EC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Agonist activity at recombinant ORL1 receptor Gln205Ala mutant expressed in COS7 cells assessed as stimulation of GTPgammaS binding	F	8.92	pEC50	1.2	nM	EC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
ChEMBL	Agonist activity at recombinant ORL1 receptor Tyr207Ala mutant expressed in COS7 cells assessed as stimulation of GTPgammaS binding	F	8.96	pEC50	1.1	nM	EC50	Bioorg Med Chem (2009) 17: 7904-7908 [PMID:19879767]
Nociceptin receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5492] [UniProtKB: P47748]
ChEMBL	Agonist activity at NOP receptor in Albino guinea pig ileum assessed as effect on electrically stimulated contractions	F	8.05	pEC50	8.91	nM	EC50	Bioorg Med Chem (2007) 15: 4434-4443 [PMID:17490886]
ChEMBL	Inhibition of electrically evoked contraction of guinea pig ileum	F	8.28	pEC50	5.25	nM	EC50	J Med Chem (2005) 48: 1421-1427 [PMID:15743186]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]