L-054,522 [Ligand Id: 2046] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL99895
  • SST1 receptor/Somatostatin receptor 1 in Human [ChEMBL: CHEMBL1917] [GtoPdb: 355] [UniProtKB: P30872]
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  • SST2 receptor/Somatostatin receptor 2 in Human [ChEMBL: CHEMBL1804] [GtoPdb: 356] [UniProtKB: P30874]
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  • SST3 receptor/Somatostatin receptor 3 in Human [ChEMBL: CHEMBL2028] [GtoPdb: 357] [UniProtKB: P32745]
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  • SST4 receptor/Somatostatin receptor 4 in Human [ChEMBL: CHEMBL1853] [GtoPdb: 358] [UniProtKB: P31391]
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  • SST5 receptor/Somatostatin receptor 5 in Human [ChEMBL: CHEMBL1792] [GtoPdb: 359] [UniProtKB: P35346]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
SST1 receptor/Somatostatin receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1917] [GtoPdb: 355] [UniProtKB: P30872]
ChEMBL Binding affinity towards Somatostatin receptor type 1 (hsst1) B 5.62 pKi 2392 nM Ki J Med Chem (2002) 45: 5609-5616 [PMID:12477342]
SST2 receptor/Somatostatin receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1804] [GtoPdb: 356] [UniProtKB: P30874]
GtoPdb - - 11 pKi - - - Proc Natl Acad Sci USA (1998) 95: 10836-41 [PMID:9724791]
ChEMBL Binding affinity towards Somatostatin receptor type 2 (hsst2) B 11 pKi 0.01 nM Ki J Med Chem (2002) 45: 5609-5616 [PMID:12477342]
ChEMBL Inhibition of [125 I -Tyr]SRIF-14 binding to membranes isolated from CHO-K1 cells expressing each of the cloned human SRIF receptor (sst-2) subtypes B 11 pKi 0.01 nM Ki J Med Chem (2001) 44: 2990-3000 [PMID:11520208]
SST3 receptor/Somatostatin receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2028] [GtoPdb: 357] [UniProtKB: P32745]
ChEMBL Binding affinity towards Somatostatin receptor type 3 (hsst3) B 7.51 pKi 31 nM Ki J Med Chem (2002) 45: 5609-5616 [PMID:12477342]
SST4 receptor/Somatostatin receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1853] [GtoPdb: 358] [UniProtKB: P31391]
ChEMBL Binding affinity towards Somatostatin receptor type 4 (hsst4) B 7.09 pKi 81 nM Ki J Med Chem (2002) 45: 5609-5616 [PMID:12477342]
SST5 receptor/Somatostatin receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1792] [GtoPdb: 359] [UniProtKB: P35346]
ChEMBL Binding affinity towards Somatostatin receptor type 5 (hsst5) B 6.79 pKi 163 nM Ki J Med Chem (2002) 45: 5609-5616 [PMID:12477342]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]