ChEMBL ligand: CHEMBL261641 (SU-11274)
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864, P24941] There should be some charts here, you may need to enable JavaScript!
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] Hepatocyte growth factor receptor in Dog [ChEMBL: CHEMBL2046265] [UniProtKB: Q75ZY9] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289] There should be some charts here, you may need to enable JavaScript!
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864, P24941]
ChEMBL	Inhibition of human recombinant CDK2/CycE using HHASPRK as substrate by ESI-MS analysis	B	6.31	pKi	489.78	nM	Ki	J Med Chem (2012) 55: 1926-1939 [PMID:22289061]
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
ChEMBL	Inhibition of Met-mediated tumorigenesis in HGF-stimulated human HepG2 cells assessed as impairment in anchorage-independent growth by soft agar growth assay	B	5.81	pIC50	1561	nM	IC50	Eur J Med Chem (2012) 47: 239-254 [PMID:22138308]
ChEMBL	Inhibition of Met-mediated tumorigenesis in HGF-stimulated human GTL16 cells assessed as impairment in anchorage-independent growth by soft agar growth assay	B	6.64	pIC50	228	nM	IC50	Eur J Med Chem (2012) 47: 239-254 [PMID:22138308]
ChEMBL	Inhibition of Met-mediated scattering in HGF-stimulated human MDCK cells pre-incubated overnight prior to HGF stimulation for 24 hrs measured after 24 to 48 hrs	B	6.82	pIC50	152	nM	IC50	Eur J Med Chem (2012) 47: 239-254 [PMID:22138308]
ChEMBL	Inhibition of human c-MET	B	7.7	pIC50	20	nM	IC50	Eur J Med Chem (2011) 46: 3675-3680 [PMID:21641696]
ChEMBL	Inhibition of Met kinase	B	7.7	pIC50	20	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL	Inhibition of purified recombinant c-Met after 60 mins by ELISA	B	7.85	pIC50	14	nM	IC50	J Med Chem (2011) 54: 2127-2142 [PMID:21405128]
GtoPdb	Assay used a GST fusion with the cytoplasmic domain of human Met.	-	8	pIC50	10	nM	IC50	Mol Cancer Ther (2003) 2: 1085-92 [PMID:14617781]
ChEMBL	Inhibition of human recombinant c-MET kinase in A549 cells assessed as inhibition of HGF-induced cell growth	B	8	pIC50	10	nM	IC50	J Med Chem (2011) 54: 6342-6363 [PMID:21812414]
Hepatocyte growth factor receptor in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2046265] [UniProtKB: Q75ZY9]
ChEMBL	Inhibition of Met-triggered cell scattering in HGF-stimulated MDCK cells preincubated for overnight before HGF challenge measured after 24 to 48 hrs	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4693-4696 [PMID:22738633]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2mef trophozoite form by hoechst 33342-thiazole orange stain based flow cytometry assay	F	6.21	pIC50	620	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5452-5457 [PMID:19666223]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2mef assessed as DNA positive erythrocytes by hoechst 33342-thiazole orange stain based flow cytometry assay	F	6.49	pIC50	320	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5452-5457 [PMID:19666223]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2mef schizont form by hoechst 33342-thiazole orange stain based flow cytometry assay	F	6.5	pIC50	317	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5452-5457 [PMID:19666223]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2mef ring form by hoechst 33342-thiazole orange stain based flow cytometry assay	F	6.64	pIC50	228	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5452-5457 [PMID:19666223]
protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289]
ChEMBL	Inhibition of human recombinant PYK2 by ESI-MS analysis	B	7.98	pKi	10.47	nM	Ki	J Med Chem (2012) 55: 1926-1939 [PMID:22289061]
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
ChEMBL	Inhibition of human recombinant ZAP70 using EEEEYEEEE as substrate by ESI-MS analysis	B	5	pKi	>10000	nM	Ki	J Med Chem (2012) 55: 1926-1939 [PMID:22289061]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]