Compound class:
Synthetic organic
Comment: Nitrosoprodenafil is a novel nitrosated analogue of the PDE5 inhibitor sildenafil, that acts as a prodrug releasing aildenafil (methisosildenafil; PubChem CID 16721107) and NO [1]. NO-induced effects on vasodilation are synergistic with inhibition of PDE5 action. This type of compound has been avoided by conventional pharmaceutical companies because of the serious risk of causing a life-threatening drop in blood pressure, and because of the hepatotoxicity of nitrosamines.
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
N-[2-[5-[5-(2,6-dimethylpiperidin-4-yl)sulfonyl-2-ethoxyphenyl]-1-methyl-3-propylpyrazolo[4,3-d]pyrimidin-7-yl]oxy-1,3-thiazol-5-yl]-N-methylnitrous amide |
Database Links ![]() |
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GtoPdb PubChem SID | 336446938 |
PubChem CID | 71308247 |
Search Google for chemical match using the InChIKey | BNIFBESUYAAZKT-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | BNIFBESUYAAZKT |
UniChem Compound Search for chemical match using the InChIKey | BNIFBESUYAAZKT-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | BNIFBESUYAAZKT-UHFFFAOYSA-N |