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Compound class: Synthetic organic
Comment: Nitrosoprodenafil is a novel nitrosated analogue of the PDE5 inhibitor sildenafil, that acts as a prodrug releasing aildenafil (methisosildenafil; PubChem CID 16721107) and NO . NO-induced effects on vasodilation are synergistic with inhibition of PDE5 action. This type of compound has been avoided by conventional pharmaceutical companies because of the serious risk of causing a life-threatening drop in blood pressure, and because of the hepatotoxicity of nitrosamines.
1. Venhuis BJ, Zomer G, Hamzink M, Meiring HD, Aubin Y, de Kaste D. (2011)
The identification of a nitrosated prodrug of the PDE-5 inhibitor aildenafil in a dietary supplement: a Viagra with a pop.
J Pharm Biomed Anal, 54 (4): 735-41. [PMID:21145686]