AZD6605 [Ligand Id: 7823] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2409707
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  • MMP13/Matrix metalloproteinase 13 in Human [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
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  • MMP14/Matrix metalloproteinase 14 in Human [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
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  • MMP2 in Human [GtoPdb: 1629] [UniProtKB: P08253]
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  • MMP9 in Human [GtoPdb: 1633] [UniProtKB: P14780]
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  • MMP12 in Human [GtoPdb: 1636] [UniProtKB: P39900]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG channel by electrophysiological assay B 4.4 pIC50 40000 nM IC50 Bioorg Med Chem Lett (2013) 23: 4705-4712 [PMID:23810497]
MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
GtoPdb - - 8.3 pIC50 5 nM IC50 AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor.. MRC/AstraZeneca: Mechanisms of Disease Call
ChEMBL Inhibition of human recombinant MMP-13 using Mca-Pro-beta-cyclohexyl-Ala-Gly-Nva-His-Ala-Dap(Dnp)-NH2 as substrate after 20 hrs by fluorescence assay B 8.33 pIC50 4.7 nM IC50 Bioorg Med Chem Lett (2013) 23: 4705-4712 [PMID:23810497]
MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
ChEMBL Inhibition of human recombinant MMP-14 using Mca-Pro-Leu-Ala-Nva-Dpa-Ala-Arg-NH2 as substrate after 20 hrs by fluorescence assay B 5.65 pIC50 2220 nM IC50 Bioorg Med Chem Lett (2013) 23: 4705-4712 [PMID:23810497]
MMP2 in Human [GtoPdb: 1629] [UniProtKB: P08253]
GtoPdb - - 8.52 pIC50 3 nM IC50 AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor.. MRC/AstraZeneca: Mechanisms of Disease Call
MMP9 in Human [GtoPdb: 1633] [UniProtKB: P14780]
GtoPdb - - 8.7 pIC50 2 nM IC50 AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor.. MRC/AstraZeneca: Mechanisms of Disease Call
MMP12 in Human [GtoPdb: 1636] [UniProtKB: P39900]
GtoPdb - - 9.22 pIC50 0.6 nM IC50 AZD6605 Matrix metallopeptidase 13 (MMP13) inhibitor.. MRC/AstraZeneca: Mechanisms of Disease Call

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]