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Synonyms: ALX-148 | ALX148
Compound class:
Peptide or derivative
Comment: Evorpacept (ALX148) is a dimeric CD47-binding fusion protein that contains two copies of a modified SIRPα D1 domain fused to an inactive human IgG1 Fc domain [1]. It blocks the CD47-SIRPα "don't eat me" (anti-phagocytic) signal.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
Classification  |
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| Compound class | Peptide or derivative |
| International Nonproprietary Names |
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| INN number | INN |
| 12029 | evorpacept |
| Synonyms |
| ALX-148 | ALX148 |
| Database Links |
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| GtoPdb PubChem SID | 442878626 |
| Search PubMed clinical trials | evorpacept |
| Search PubMed titles | evorpacept |
| Search PubMed titles/abstracts | evorpacept |
