ChEMBL ligand: CHEMBL3629569
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902] There should be some charts here, you may need to enable JavaScript!
tryptophan 2,3-dioxygenase/Tryptophan 2,3-dioxygenase in Human [ChEMBL: CHEMBL2140] [GtoPdb: 2887] [UniProtKB: P48775] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902]
ChEMBL	Binding affinity to NT647 dye labeled recombinant human IDO1 (1 to 403 residues) by microscale thermophoresis method	B	5.48	pKd	3300	nM	Kd	Eur J Med Chem (2017) 141: 169-177 [PMID:29031064]
ChEMBL	Inhibition of IDO1 (unknown origin) by in-vitro assay	B	8.14	pKi	7.2	nM	Ki	Eur J Med Chem (2017) 140: 293-304 [PMID:28963992]
ChEMBL	Inhibition of IDO1 (unknown origin)	B	8.15	pKi	7	nM	Ki	Medchemcomm (2017) 8: 1378-1392 [PMID:30108849]
GtoPdb	-	-	8.24	pKi	5.8	nM	Ki	J Med Chem (2019) 62: 6705-6733 [PMID:31264862]
ChEMBL	Inhibition of recombinant human IDO1 assessed as L-kynurenine release preincubated for 5 mins followed by addition of L-tryptophan for 15 mins by spectrophotometer	B	6	pIC50	<1000	nM	IC50	Medchemcomm (2016) 7: 409-419
ChEMBL	Inhibition of C-terminal 6His-tagged human IDO using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition measured after 15 mins by spectrophotometric analysis	B	6	pIC50	<1000	nM	IC50	J Med Chem (2015) 58: 9421-9437 [PMID:25970480]
ChEMBL	Inhibition of human IDO1	B	6	pIC50	<1000	nM	IC50	J Med Chem (2015) 58: 8762-8782 [PMID:26207924]
ChEMBL	Inhibition of full length recombinant human His-tagged IDO1 expressed in mouse LLTC cells using L-tryptophan as substrate after 24 hrs	B	6.23	pIC50	590	nM	IC50	Eur J Med Chem (2017) 126: 983-996 [PMID:28011425]
ChEMBL	Inhibition of IFNgamma-induced IDO1 in human HeLa cells using L-tryptophan as substrate after 24 hrs	B	6.39	pIC50	410	nM	IC50	Eur J Med Chem (2017) 138: 199-211 [PMID:28667875]
ChEMBL	Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 24 hrs	B	6.72	pIC50	190	nM	IC50	Eur J Med Chem (2019) 184: 111750-111750 [PMID:31610376]
ChEMBL	Inhibition of recombinant human IDO1 S167A mutant expressed in Escherichia coli SG13009(pREP4) using L-Tryptophan as substrate after 25 mins by fluorescence assay	B	6.89	pIC50	130	nM	IC50	Eur J Med Chem (2017) 126: 983-996 [PMID:28011425]
ChEMBL	Inhibition of recombinant human IDO1 expressed in Escherichia coli EC538 assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 30 mins by methylene blue reagent based concurrent assay	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem (2021) 39: 116160-116160 [PMID:33901770]
ChEMBL	Inhibition of recombinant human IDO1 expressed in Escherichia coli EC538 assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 30 mins by methylene blue reagent based assay	B	7.1	pIC50	80	nM	IC50	Bioorg Med Chem (2021) 39: 116160-116160 [PMID:33901770]
ChEMBL	Inhibition of purified human IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins by spectrophotometric method	B	7.22	pIC50	60	nM	IC50	J Med Chem (2019) 62: 6705-6733 [PMID:31264862]
ChEMBL	Inhibition of recombinant human IDO1 expressed in bacterial expression system using L-Tryptophan as substrate after 25 mins in absence of GSH and presence of tween20 by fluorescence assay	B	7.22	pIC50	60	nM	IC50	Eur J Med Chem (2017) 126: 983-996 [PMID:28011425]
ChEMBL	Inhibition of recombinant human IDO1 assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 45 mins by methylene blue reagent based assay	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem (2021) 39: 116160-116160 [PMID:33901770]
ChEMBL	Inhibition of recombinant human IDO1 assessed as conversion of N-formylkynurenine to kynurenine incubated for 1 hr by fluorescence analysis	B	7.42	pIC50	38	nM	IC50	J Med Chem (2016) 59: 282-293 [PMID:26642377]
ChEMBL	Inhibition of IDO1 (unknown origin)	B	7.55	pIC50	28	nM	IC50	Medchemcomm (2016) 7: 409-419
ChEMBL	Inhibition of recombinant human IDO1 expressed in T-REx-293 cells assessed as reduction in kynurenine level measured after 16 hrs	B	7.08	pEC50	83	nM	EC50	J Med Chem (2019) 62: 6705-6733 [PMID:31264862]
ChEMBL	Inhibition of IDO1 (unknown origin) by cell based assay	B	7.12	pEC50	75	nM	EC50	Eur J Med Chem (2017) 140: 293-304 [PMID:28963992]
ChEMBL	Inhibition of IDO1 (unknown origin) by cell based assay	B	7.12	pEC50	75	nM	EC50	Medchemcomm (2017) 8: 1378-1392 [PMID:30108849]
ChEMBL	Inhibition of IDO1 in IFNgamma-stimulated human HeLa cells incubated for 24 hrs	B	7.21	pEC50	61	nM	EC50	J Med Chem (2016) 59: 282-293 [PMID:26642377]
tryptophan 2,3-dioxygenase/Tryptophan 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2140] [GtoPdb: 2887] [UniProtKB: P48775]
GtoPdb	-	-	6	pIC50	<1000	nM	IC50	J Med Chem (2015) 58: 8762-82 [PMID:26207924]
ChEMBL	Inhibition of TDO (unknown origin)	B	6	pIC50	<1000	nM	IC50	J Med Chem (2015) 58: 8762-8782 [PMID:26207924]
ChEMBL	Inhibition of recombinant human TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 30 mins by methylene blue reagent based concurrent assay	B	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2021) 39: 116160-116160 [PMID:33901770]
ChEMBL	Inhibition of recombinant human TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 30 mins by methylene blue reagent based assay	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem (2021) 39: 116160-116160 [PMID:33901770]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]