propanoic acid [Ligand Id: 1062] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL14021 (E280, Propionic acid, Ethanecarboxylic acid, INS-280, E-280, FEMA NO. 2924, INS NO.280)
  • FFA3 receptor/Free fatty acid receptor 3 in Human [ChEMBL: CHEMBL5201] [GtoPdb: 227] [UniProtKB: O14843]
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  • FFA2 receptor in Human [GtoPdb: 226] [UniProtKB: O15552]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
FFA3 receptor/Free fatty acid receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5201] [GtoPdb: 227] [UniProtKB: O14843]
ChEMBL Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method B 4.92 pEC50 12000 nM EC50 J Med Chem (2018) 61: 47-61 [PMID:28745893]
ChEMBL Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay B 4.93 pEC50 11748.98 nM EC50 J Med Chem (2020) 63: 3577-3595 [PMID:32141297]
ChEMBL Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry B 4.97 pEC50 10715.19 nM EC50 J Med Chem (2020) 63: 3577-3595 [PMID:32141297]
GtoPdb - - 5.7 pEC50 - - - J Biol Chem (2003) 278: 11312-9 [PMID:12496283];
J Biol Chem (2003) 278: 25481-9 [PMID:12711604];
Proc Natl Acad Sci USA (2004) 101: 1045-50 [PMID:14722361];
J Biol Chem (2011) 286: 10628-40 [PMID:21220428]
FFA2 receptor in Human [GtoPdb: 226] [UniProtKB: O15552]
GtoPdb - - 4.9 pEC50 - - - J Biol Chem (2003) 278: 11312-9 [PMID:12496283];
Biochem Biophys Res Commun (2003) 303: 1047-52 [PMID:12684041];
J Biol Chem (2003) 278: 25481-9 [PMID:12711604];
J Biol Chem (2011) 286: 10628-40 [PMID:21220428]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]