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ChEMBL ligand: CHEMBL2058156 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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LPA5 receptor/Lysophosphatidic acid receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5700] [GtoPdb: 124] [UniProtKB: Q9H1C0] | ||||||||
ChEMBL | Antagonist activity at LPA5 receptor in human isolated platelets assessed as inhibition of hexadecyl-LPA-induced platelet aggregation after 3 mins | F | 5.66 | pIC50 | 2200 | nM | IC50 | Bioorg. Med. Chem. Lett. (2012) 22: 5239-5243 [PMID:22801643] |
ChEMBL | Antagonist activity at human recombinant LPA5 receptor expressed in rat RH7777 cells assessed as inhibition of hexadecyl-LPA-induced effect | F | 6.1 | pIC50 | 800 | nM | IC50 | Bioorg. Med. Chem. Lett. (2012) 22: 5239-5243 [PMID:22801643] |
ChEMBL | Antagonist activity at LPA5 receptor in human washed platelets assessed as inhibition of hexadecyl-LPA-induced platelet aggregation after 3 mins | F | 6.1 | pIC50 | 800 | nM | IC50 | Bioorg. Med. Chem. Lett. (2012) 22: 5239-5243 [PMID:22801643] |
GtoPdb | Inhibitor of KI6425-induced activation of a LPA5-RH7777 cell line. | - | 6.1 | pIC50 | 800 | nM | IC50 | Bioorg. Med. Chem. Lett. (2012) 22: 5239-43 [PMID:22801643] |
LPA2 receptor/Lysophosphatidic acid receptor Edg-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3724] [GtoPdb: 273] [UniProtKB: Q9HBW0] | ||||||||
ChEMBL | Antagonist activity at LPA2 receptor in human isolated platelets assessed as inhibition of TRAP-induced platelet aggregation after 3 mins | F | 5 | pIC50 | >10000 | nM | IC50 | Bioorg. Med. Chem. Lett. (2012) 22: 5239-5243 [PMID:22801643] |
ChEMBL data shown on this page come from version 27:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]