TCLPA5 [Ligand Id: 9500] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2058156
  • LPA5 receptor/Lysophosphatidic acid receptor 5 in Human [ChEMBL: CHEMBL5700] [GtoPdb: 124] [UniProtKB: Q9H1C0]
  • This target only has 0 pki data point
1 CHEMBL2058156_lig_chart_1 Lysophosphatidic acid receptor 5 Human
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  • LPA2 receptor/Lysophosphatidic acid receptor Edg-4 in Human [ChEMBL: CHEMBL3724] [GtoPdb: 273] [UniProtKB: Q9HBW0]
  • This target only has 0 pki data point
2 CHEMBL2058156_lig_chart_2 Lysophosphatidic acid receptor Edg-4 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
LPA5 receptor/Lysophosphatidic acid receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5700] [GtoPdb: 124] [UniProtKB: Q9H1C0]
ChEMBL Antagonist activity at LPA5 receptor in human isolated platelets assessed as inhibition of hexadecyl-LPA-induced platelet aggregation after 3 mins F 5.66 pIC50 2200 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 5239-5243 [PMID:22801643]
ChEMBL Antagonist activity at human recombinant LPA5 receptor expressed in rat RH7777 cells assessed as inhibition of hexadecyl-LPA-induced effect F 6.1 pIC50 800 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 5239-5243 [PMID:22801643]
ChEMBL Antagonist activity at LPA5 receptor in human washed platelets assessed as inhibition of hexadecyl-LPA-induced platelet aggregation after 3 mins F 6.1 pIC50 800 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 5239-5243 [PMID:22801643]
GtoPdb Inhibitor of KI6425-induced activation of a LPA5-RH7777 cell line. - 6.1 pIC50 800 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 5239-43 [PMID:22801643]
LPA2 receptor/Lysophosphatidic acid receptor Edg-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3724] [GtoPdb: 273] [UniProtKB: Q9HBW0]
ChEMBL Antagonist activity at LPA2 receptor in human isolated platelets assessed as inhibition of TRAP-induced platelet aggregation after 3 mins F 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 5239-5243 [PMID:22801643]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]