Synonyms: AKST-4290 | AKST4290 | ALK-4290 | ALK4290 | Example 11 [WO2012045803A1]
Compound class:
Synthetic organic
Comment: Lazucirnon (AKST4290, formerly known as ALK4290) is a CCR3 antagonist that was developed by Alkahest as a novel oral therapy for wet age-related macular degeneration (AMD). It acts as a modulator of pathologic inflammation by inhibiting the CCR3/eotaxin axis and subsequent eosinophil accumulation. ALK4290 is now being repurposed for Parkinson's disease. The structure that is presented here was obtained from the NIH ChemIDplus chemical information resource, where it is listed as ALK4290. The structure matches example 11 that is claimed in patent WO2012045803A1 which was granted to Boehringer Ingelheim [2].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
Classification ![]() |
|
Compound class | Synthetic organic |
IUPAC Name ![]() |
2-[[(2R)-1-[1-[(4-chloro-3-methylphenyl)methyl]piperidin-4-yl]-5-oxopyrrolidine-2-carbonyl]amino]-N,N,6-trimethylpyridine-4-carboxamide |
International Nonproprietary Names ![]() |
|
INN number | INN |
11481 | lazucirnon |
Synonyms ![]() |
AKST-4290 | AKST4290 | ALK-4290 | ALK4290 | Example 11 [WO2012045803A1] |
Database Links ![]() |
|
Specialist databases | |
GPCRdb Ligand | lazucirnon |
Other databases | |
CAS Registry No. | 1251528-23-0 (source: PubChem) |
ChEMBL Ligand | CHEMBL3670800 |
GtoPdb PubChem SID | 404859100 |
PubChem CID | 59534386 |
Search Google for chemical match using the InChIKey | DWKNOLCXIFYNFV-HSZRJFAPSA-N |
Search Google for chemicals with the same backbone | DWKNOLCXIFYNFV |
Search PubMed clinical trials | lazucirnon |
Search PubMed titles | lazucirnon |
Search PubMed titles/abstracts | lazucirnon |
UniChem Compound Search for chemical match using the InChIKey | DWKNOLCXIFYNFV-HSZRJFAPSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | DWKNOLCXIFYNFV-HSZRJFAPSA-N |
Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.
Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.
✖
ALK4290 (links to external site)
Cat. No. HY-136788 |