citric acid [Ligand Id: 2478] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1261 (E-330, INS-330, E330, NSC-112226, Citric acid, anhydrous, Anhydrous citric acid, Citric Acid, Citric acid hydrate, INS NO.330, NSC-30279, NSC-626579, FEMA NO. 2306, Urologic G)
  • 3-dehydroquinate dehydratase in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) [ChEMBL: CHEMBL4680] [UniProtKB: Q48255]
  • 3-dehydroquinate dehydratase in Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [ChEMBL: CHEMBL5276] [UniProtKB: P15474]
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  • TRPP2 in Human [GtoPdb: 505] [UniProtKB: Q9P0L9]
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  • TRPV4 in Mouse [GtoPdb: 510] [UniProtKB: Q9EPK8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
3-dehydroquinate dehydratase in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4680] [UniProtKB: Q48255]
ChEMBL Binding affinity for Helicobacter pylori DHQase 2 B 5.6 pKd 2500 nM Kd J. Med. Chem. (2006) 49: 1282-1290 [PMID:16480265]
3-dehydroquinate dehydratase in Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5276] [UniProtKB: P15474]
ChEMBL Binding affinity for Streptomyces coelicolor DHQase 2 B 5.14 pKd 7300 nM Kd J. Med. Chem. (2006) 49: 1282-1290 [PMID:16480265]
TRPP2 in Human [GtoPdb: 505] [UniProtKB: Q9P0L9]
GtoPdb - - 1.7 pEC50 - - - Proc. Natl. Acad. Sci. U.S.A. (2006) 103: 12569-74 [PMID:16891422]
TRPV4 in Mouse [GtoPdb: 510] [UniProtKB: Q9EPK8]
GtoPdb - - 5.6 pEC50 - - - J. Biol. Chem. (2003) 278: 22664-8 [PMID:12692122]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]