citric acid [Ligand Id: 2478] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1261 (Acidum citricum, Acidum citricum monohydrate, Aciletten, Anhydrous citric acid, B1650, Citrate, Citric acid, Citric Acid, Citric acid anhydrous, Citric acid, anhydrous, Citric acid,anhydrous, Citric acid bp, Citric acid hydrate, Citric acid, hydrous, Citric acid,hydrous, Citric acid monoglyceride, Citricum acidum, E-330, E330, FEMA NO. 2306, INS-330, INS NO.330, NSC-112226, NSC-30279, NSC-626579, Urologic G)
  • 3-dehydroquinate dehydratase in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) [ChEMBL: CHEMBL4680] [UniProtKB: Q48255]
  • 3-dehydroquinate dehydratase in Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [ChEMBL: CHEMBL5276] [UniProtKB: P15474]
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  • TRPP2 in Human [GtoPdb: 505] [UniProtKB: Q9P0L9]
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  • TRPV4 in Mouse [GtoPdb: 510] [UniProtKB: Q9EPK8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
3-dehydroquinate dehydratase in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4680] [UniProtKB: Q48255]
ChEMBL Binding affinity for Helicobacter pylori DHQase 2 B 5.6 pKd 2500 nM Kd J Med Chem (2006) 49: 1282-1290 [PMID:16480265]
3-dehydroquinate dehydratase in Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5276] [UniProtKB: P15474]
ChEMBL Binding affinity for Streptomyces coelicolor DHQase 2 B 5.14 pKd 7300 nM Kd J Med Chem (2006) 49: 1282-1290 [PMID:16480265]
TRPP2 in Human [GtoPdb: 505] [UniProtKB: Q9P0L9]
GtoPdb - - 1.7 pEC50 - - - Proc Natl Acad Sci USA (2006) 103: 12569-74 [PMID:16891422]
TRPV4 in Mouse [GtoPdb: 510] [UniProtKB: Q9EPK8]
GtoPdb - - 5.6 pEC50 - - - J Biol Chem (2003) 278: 22664-8 [PMID:12692122]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]