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ChEMBL ligand: CHEMBL1261 (Citric acid, E-330, INS-330, E330, NSC-112226, Anhydrous citric acid, Citric Acid, Citric acid hydrate, INS NO.330, NSC-30279, NSC-626579, FEMA NO. 2306, Urologic G, Citric acid, anhydrous) |
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2
CHEMBL1261_lig_chart_2
TRPP2
Human
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3
CHEMBL1261_lig_chart_3
TRPV4
Mouse
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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3-dehydroquinate dehydratase in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4680] [UniProtKB: Q48255] | ||||||||
ChEMBL | Binding affinity for Helicobacter pylori DHQase 2 | B | 5.6 | pKd | 2500 | nM | Kd | J. Med. Chem. (2006) 49: 1282-1290 [PMID:16480265] |
3-dehydroquinate dehydratase in Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5276] [UniProtKB: P15474] | ||||||||
ChEMBL | Binding affinity for Streptomyces coelicolor DHQase 2 | B | 5.14 | pKd | 7300 | nM | Kd | J. Med. Chem. (2006) 49: 1282-1290 [PMID:16480265] |
TRPP2 in Human [GtoPdb: 505] [UniProtKB: Q9P0L9] | ||||||||
GtoPdb | - | - | 1.7 | pEC50 | - | - | - | Proc Natl Acad Sci USA (2006) 103: 12569-74 [PMID:16891422] |
TRPV4 in Mouse [GtoPdb: 510] [UniProtKB: Q9EPK8] | ||||||||
GtoPdb | - | - | 5.6 | pEC50 | - | - | - | J Biol Chem (2003) 278: 22664-8 [PMID:12692122] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]