citric acid [Ligand Id: 2478] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1261 (Acidum citricum, Acidum citricum monohydrate, Aciletten, Anhydrous citric acid, B1650, Citrate, Citric acid, Citric Acid, Citric acid anhydrous, Citric acid,anhydrous, Citric acid, anhydrous, Citric acid bp, Citric acid hydrate, Citric acid,hydrous, Citric acid, hydrous, Citric acid monoglyceride, Citricum acidum, E330, E-330, FEMA NO. 2306, INS-330, INS NO.330, NSC-112226, NSC-30279, NSC-626579, Urologic G)
  • 3-dehydroquinate dehydratase in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) [ChEMBL: CHEMBL4680] [UniProtKB: Q48255]
  • 3-dehydroquinate dehydratase in Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [ChEMBL: CHEMBL5276] [UniProtKB: P15474]
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  • TRPP2 in Human [GtoPdb: 505] [UniProtKB: Q9P0L9]
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  • TRPV4 in Mouse [GtoPdb: 510] [UniProtKB: Q9EPK8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
3-dehydroquinate dehydratase in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4680] [UniProtKB: Q48255]
ChEMBL Binding affinity for Helicobacter pylori DHQase 2 B 5.6 pKd 2500 nM Kd J. Med. Chem. (2006) 49: 1282-1290 [PMID:16480265]
3-dehydroquinate dehydratase in Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5276] [UniProtKB: P15474]
ChEMBL Binding affinity for Streptomyces coelicolor DHQase 2 B 5.14 pKd 7300 nM Kd J. Med. Chem. (2006) 49: 1282-1290 [PMID:16480265]
TRPP2 in Human [GtoPdb: 505] [UniProtKB: Q9P0L9]
GtoPdb - - 1.7 pEC50 - - - Proc Natl Acad Sci USA (2006) 103: 12569-74 [PMID:16891422]
TRPV4 in Mouse [GtoPdb: 510] [UniProtKB: Q9EPK8]
GtoPdb - - 5.6 pEC50 - - - J Biol Chem (2003) 278: 22664-8 [PMID:12692122]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]