almotriptan [Ligand Id: 7110] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1505 (Almotriptan, LAS 31416, LAS-31416, NSC-760092)
  • 5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
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  • 5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
GtoPdb Affinity of almotriptan at recombinant h5-HT1B receptors expressed in HeLa cells, determined in a radioligand displacement assay using [125I]GTI as tracer. - 7.92 pIC50 12 nM IC50 Eur J Pharmacol (2000) 410: 33-41 [PMID:11134654]
5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb Affinity of almotriptan at recombinant h5-HT1D receptors expressed in HeLa cells, determined in a radioligand displacement assay using [125I]GTI as tracer. - 7.89 pIC50 13 nM IC50 Eur J Pharmacol (2000) 410: 33-41 [PMID:11134654]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]