almotriptan [Ligand Id: 7110] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1505 (Almotriptan, LAS 31416, LAS-31416, NSC-760092)
  • 5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
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  • 5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
GtoPdb Affinity of almotriptan at recombinant h5-HT1B receptors expressed in HeLa cells, determined in a radioligand displacement assay using [125I]GTI as tracer. - 7.92 pIC50 12 nM IC50 Eur J Pharmacol (2000) 410: 33-41 [PMID:11134654]
5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb Affinity of almotriptan at recombinant h5-HT1D receptors expressed in HeLa cells, determined in a radioligand displacement assay using [125I]GTI as tracer. - 7.89 pIC50 13 nM IC50 Eur J Pharmacol (2000) 410: 33-41 [PMID:11134654]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]