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ChEMBL ligand: CHEMBL1505 (Almotriptan, LAS 31416, LAS-31416, NSC-760092) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
GtoPdb | Affinity of almotriptan at recombinant h5-HT1B receptors expressed in HeLa cells, determined in a radioligand displacement assay using [125I]GTI as tracer. | - | 7.92 | pIC50 | 12 | nM | IC50 | Eur J Pharmacol (2000) 410: 33-41 [PMID:11134654] |
5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
GtoPdb | Affinity of almotriptan at recombinant h5-HT1D receptors expressed in HeLa cells, determined in a radioligand displacement assay using [125I]GTI as tracer. | - | 7.89 | pIC50 | 13 | nM | IC50 | Eur J Pharmacol (2000) 410: 33-41 [PMID:11134654] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]