compound 1c [Brown et al., 1997] [Ligand Id: 3105] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL24362 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| lanosterol synthase/Lanosterol synthase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3262] [GtoPdb: 2434] [UniProtKB: P48450] | ||||||||
| ChEMBL | Inhibition of compound was measured on rat microsomal Oxidosqualene-lanosterol cyclase | B | 7 | pIC50 | >100 | nM | IC50 | J Med Chem (1999) 42: 1306-1311 [PMID:10197973] |
| squalene synthase /Squalene synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3338] [GtoPdb: 645] [UniProtKB: P37268] | ||||||||
| ChEMBL | Tested for its inhibitory activity against human microsomal quinuclidine squalene synthase (SQS) | B | 7.37 | pKi | 43 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 597-600 |
| GtoPdb | Tested for its inhibitory activity against human microsomal quinuclidine squalene synthase (SQS) | - | 7.37 | pKi | 43 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 597-600 |
| squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] | ||||||||
| ChEMBL | Tested for its inhibitory activity against rat microsomal quinuclidine squalene synthase (SQS) | B | 8.22 | pKi | 6 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 597-600 |
| ChEMBL | Compound was measured for the inhibition of rat microsomal squalene synthase enzyme | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (1999) 42: 1306-1311 [PMID:10197973] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
