benazeprilat [Ligand Id: 6375] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1192519 (Benazeprilat, CGS 14831)
  • Angiotensin-converting enzyme in Rabbit [ChEMBL: CHEMBL4074] [UniProtKB: P12822]
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  • Angiotensin-converting enzyme in Human [GtoPdb: 1613] [UniProtKB: P12821]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822]
ChEMBL Tested in vitro for the inhibition against angiotensin converting enzyme (ACE) from rabbit lung B 8.7 pIC50 2 nM IC50 J. Med. Chem. (1993) 36: 3829-3833 [PMID:8254612]
Angiotensin-converting enzyme in Human [GtoPdb: 1613] [UniProtKB: P12821]
GtoPdb - - 6.6 pIC50 280 nM IC50 Curr Pharm Des (2007) 13: 1347-61 [PMID:17506720]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]