benazeprilat [Ligand Id: 6375] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1192519 (Benazeprilat, Benazepril diacid, Benazepril related compound c, CGS 14831, CGS-14831)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
GtoPdb - - 6.6 pIC50 280 nM IC50 Curr Pharm Des (2007) 13: 1347-61 [PMID:17506720]
ChEMBL Inhibition of angiotensin-converting enzyme (unknown origin) B 8.77 pIC50 1.7 nM IC50 J Med Chem (2016) 59: 10865-10890 [PMID:27690430]
Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822]
ChEMBL Tested in vitro for the inhibition against angiotensin converting enzyme (ACE) from rabbit lung B 8.7 pIC50 2 nM IC50 J Med Chem (1993) 36: 3829-3833 [PMID:8254612]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]