ChEMBL ligand: CHEMBL4297442 (GB-0139, GB0139, Olitigaltin, Olitigaltina, Olitigaltine, Td 139, Td-139, Td139, TD-139, TD139)
Galectin-1 in Human [ChEMBL: CHEMBL4915] [UniProtKB: P09382] There should be some charts here, you may need to enable JavaScript!
Galectin-3 in Human [ChEMBL: CHEMBL4531] [UniProtKB: P17931] Galectin-3 in Mouse [ChEMBL: CHEMBL3668] [UniProtKB: P16110] There should be some charts here, you may need to enable JavaScript!
Galectin-8 in Human [ChEMBL: CHEMBL5475] [UniProtKB: O00214] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Galectin-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4915] [UniProtKB: P09382]
ChEMBL	Binding affinity to human Gal-1 expressed in Escherichia coli BL21 (DE3) by competitive fluorescence polarization assay	B	5.3	pKd	5000	nM	Kd	ACS Med Chem Lett (2023) 14: 1257-1265 [PMID:37736168]
ChEMBL	Binding affinity to galectin-1 (unknown origin) assessed as dissociation constant	B	7.92	pKd	12	nM	Kd	J Med Chem (2023) 66: 16980-16990 [PMID:38059452]
ChEMBL	Binding affinity to human Gal-1 expressed in Escherichia coli BL21star (DE3) by competitive fluorescence polarization assay	B	7.92	pKd	12	nM	Kd	ACS Med Chem Lett (2023) 14: 1257-1265 [PMID:37736168]
Galectin-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4531] [UniProtKB: P17931]
ChEMBL	Binding affinity to human Gal-3 expressed in Escherichia coli BL21 (DE3) cells by competitive fluorescence polarization assay	B	7.43	pKd	37	nM	Kd	ACS Med Chem Lett (2023) 14: 1257-1265 [PMID:37736168]
ChEMBL	Binding affinity to human Gal-3 expressed in Escherichia coli BL21star (DE3) cells by competitive fluorescence polarization assay	B	7.85	pKd	14	nM	Kd	ACS Med Chem Lett (2023) 14: 1257-1265 [PMID:37736168]
ChEMBL	Binding affinity to galectin-3 (unknown origin) assessed as dissociation constant	B	8.64	pKd	2.3	nM	Kd	J Med Chem (2023) 66: 16980-16990 [PMID:38059452]
ChEMBL	Binding affinity at recombinant human Galectin-3 assessed as dissociation constant by fluorescence anisotropy assay	B	8.66	pKd	2.2	nM	Kd	Bioorg Med Chem (2024) 101: 117638-117638 [PMID:38394996]
ChEMBL	Inhibition of human Gal3-induced chemotaxis using human monocyte incubated for 4 hrs by calcein-AM dye based assay	B	7.1	pIC50	80	nM	IC50	J Med Chem (2021) 64: 6634-6655 [PMID:33988358]
ChEMBL	Inhibition of biotin-asialofetuin binding to human Gal3 measured after 90 mins by HTRF competition assay	B	8	pIC50	10	nM	IC50	J Med Chem (2021) 64: 6634-6655 [PMID:33988358]
Galectin-3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3668] [UniProtKB: P16110]
ChEMBL	Inhibition of moues Gal3-induced hemagglutination using mouse RBC incubated for overnight by hemagglutination assay	B	6.52	pIC50	300	nM	IC50	J Med Chem (2021) 64: 6634-6655 [PMID:33988358]
ChEMBL	Inhibition of biotin-asialofetuin binding to mouse Gal3 measured after 90 mins by HTRF competition assay	B	7.17	pIC50	67	nM	IC50	J Med Chem (2021) 64: 6634-6655 [PMID:33988358]
Galectin-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5475] [UniProtKB: O00214]
ChEMBL	Binding affinity to N-terminal domain human Gal-8 expressed in Escherichia coli BL21star (DE3) cells by competitive fluorescence polarization assay	B	4.07	pKd	86000	nM	Kd	ACS Med Chem Lett (2023) 14: 1257-1265 [PMID:37736168]
ChEMBL	Binding affinity to C-terminal domain human Gal-8 expressed in Escherichia coli BL21 (DE3) cells by competitive fluorescence polarization assay	B	4.67	pKd	21600	nM	Kd	ACS Med Chem Lett (2023) 14: 1257-1265 [PMID:37736168]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]