pyridostigmine [Ligand Id: 8994] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1115 (Mestinon, Pyridostigmine, Pyridostigmine cation, Pyridostigmine ion, Regonol) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058] | ||||||||
| ChEMBL | Inhibition of Torpedo californica eel AChE using acetylthiocholine/DTNB as substrate preincubated for 10 mins followed by substrate addition measured every 30 secs for 30 mins by Ellmans method | B | 7.09 | pIC50 | 82 | nM | IC50 | Medchemcomm (2011) 2: 406-412 |
| Acetylcholinesterase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4768] [UniProtKB: P23795] | ||||||||
| ChEMBL | Inhibitory activity against Acetylcholinesterase (AChE) | B | 4.71 | pKi | 19700 | nM | Ki | J Med Chem (2002) 45: 902-910 [PMID:11831902] |
| ChEMBL | Concentration required to inhibit hydrolytic activity of bovine erythrocyte acetylcholinesterase by 50% | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (1991) 34: 1582-1584 [PMID:2033583] |
| butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
| ChEMBL | Inhibition of anticholinesterase activity by their ability to inactivate human serum butyrylcholinesterase | B | 5.46 | pKi | 3500 | nM | Ki | J Med Chem (1989) 32: 1522-1528 [PMID:2738887] |
| GtoPdb | Inhibition of human plasma BCHE activity by a modified Ellman assay. | - | 6.05 | pIC50 | 900 | nM | IC50 | Bioorg Med Chem (2010) 18: 4687-93 [PMID:20627738] |
| acetylcholinesterase (Yt blood group) in Human [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
| GtoPdb | Inhibition of human erythrocyte ACHE activity by a modified Ellman assay. | - | 6.44 | pIC50 | 360 | nM | IC50 | Bioorg Med Chem (2010) 18: 4687-93 [PMID:20627738] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
