Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL1115 (Mestinon, Pyridostigmine, Pyridostigmine cation, Pyridostigmine ion, Regonol) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058] | ||||||||
ChEMBL | Inhibition of Torpedo californica eel AChE using acetylthiocholine/DTNB as substrate preincubated for 10 mins followed by substrate addition measured every 30 secs for 30 mins by Ellmans method | B | 7.09 | pIC50 | 82 | nM | IC50 | Medchemcomm (2011) 2: 406-412 |
Acetylcholinesterase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4768] [UniProtKB: P23795] | ||||||||
ChEMBL | Inhibitory activity against Acetylcholinesterase (AChE) | B | 4.71 | pKi | 19700 | nM | Ki | J Med Chem (2002) 45: 902-910 [PMID:11831902] |
ChEMBL | Concentration required to inhibit hydrolytic activity of bovine erythrocyte acetylcholinesterase by 50% | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (1991) 34: 1582-1584 [PMID:2033583] |
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
ChEMBL | Inhibition of anticholinesterase activity by their ability to inactivate human serum butyrylcholinesterase | B | 5.46 | pKi | 3500 | nM | Ki | J Med Chem (1989) 32: 1522-1528 [PMID:2738887] |
GtoPdb | Inhibition of human plasma BCHE activity by a modified Ellman assay. | - | 6.05 | pIC50 | 900 | nM | IC50 | Bioorg Med Chem (2010) 18: 4687-93 [PMID:20627738] |
acetylcholinesterase (Yt blood group) in Human [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
GtoPdb | Inhibition of human erythrocyte ACHE activity by a modified Ellman assay. | - | 6.44 | pIC50 | 360 | nM | IC50 | Bioorg Med Chem (2010) 18: 4687-93 [PMID:20627738] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]