pyridostigmine [Ligand Id: 8994] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1115 (Pyridostigmine, Mestinon, Regonol)
  • Acetylcholinesterase in Torpedo californica [ChEMBL: CHEMBL4780] [UniProtKB: P04058]
  • Acetylcholinesterase in Bovine [ChEMBL: CHEMBL4768] [UniProtKB: P23795]
  • This target only has 1 pki data point
  • 4.71
1 CHEMBL1115_lig_chart_1 Acetylcholinesterase Torpedo californicaBovine
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  • butyrylcholinesterase/Butyrylcholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
  • This target only has 1 pki data point
  • 5.46
2 CHEMBL1115_lig_chart_2 Butyrylcholinesterase Human
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  • acetylcholinesterase (Cartwright blood group) in Human [GtoPdb: 2465] [UniProtKB: P22303]
  • This target only has 0 pki data point
  • 0
3 CHEMBL1115_lig_chart_3 acetylcholinesterase (Cartwright blood group) Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058]
ChEMBL Inhibition of Torpedo californica eel AChE using acetylthiocholine/DTNB as substrate preincubated for 10 mins followed by substrate addition measured every 30 secs for 30 mins by Ellmans method B 7.09 pIC50 82 nM IC50 MedChemComm (2011) 2: 406-412
Acetylcholinesterase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4768] [UniProtKB: P23795]
ChEMBL Inhibitory activity against Acetylcholinesterase (AChE) B 4.71 pKi 19700 nM Ki J. Med. Chem. (2002) 45: 902-910 [PMID:11831902]
ChEMBL Concentration required to inhibit hydrolytic activity of bovine erythrocyte acetylcholinesterase by 50% B 7.3 pIC50 50 nM IC50 J. Med. Chem. (1991) 34: 1582-1584 [PMID:2033583]
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
ChEMBL Inhibition of anticholinesterase activity by their ability to inactivate human serum butyrylcholinesterase B 5.46 pKi 3500 nM Ki J. Med. Chem. (1989) 32: 1522-1528 [PMID:2738887]
GtoPdb Inhibition of human plasma BCHE activity by a modified Ellman assay. - 6.05 pIC50 900 nM IC50 Bioorg Med Chem (2010) 18: 4687-93 [PMID:20627738]
acetylcholinesterase (Cartwright blood group) in Human [GtoPdb: 2465] [UniProtKB: P22303]
GtoPdb Inhibition of human erythrocyte ACHE activity by a modified Ellman assay. - 6.44 pIC50 360 nM IC50 Bioorg Med Chem (2010) 18: 4687-93 [PMID:20627738]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]