TQB3804 [Ligand Id: 12983] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL5169450 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | Inhibition of wild type EGFR (unknown origin) | B | 8.1 | pIC50 | 7.92 | nM | IC50 | J Med Chem (2022) 65: 1008-1046 [PMID:34323489] |
| GtoPdb | Inhibition of EGFR Del19/T790M/C797S triple mutant | - | 9.66 | pIC50 | 0.22 | nM | IC50 | WO2019015655A1. Aryl-phosphorus-oxygen compound as egfr kinase inhibitor (2019) |
| ChEMBL | Inhibition of EGFR Del19/T790M/C797S triple mutant (unknown origin) | B | 9.66 | pIC50 | 0.22 | nM | IC50 | J Med Chem (2022) 65: 1008-1046 [PMID:34323489] |
| ChEMBL | Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) | B | 9.8 | pIC50 | 0.16 | nM | IC50 | J Med Chem (2022) 65: 1008-1046 [PMID:34323489] |
| GtoPdb | Inhibition of EGFR L858R/T790M/C797S triple mutant | - | 9.8 | pIC50 | 0.16 | nM | IC50 | WO2019015655A1. Aryl-phosphorus-oxygen compound as egfr kinase inhibitor (2019) |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
