PD123319 [Ligand Id: 597] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL321820
  • FPR1/Formyl peptide receptor 1 in Human [ChEMBL: CHEMBL3359] [GtoPdb: 222] [UniProtKB: P21462]
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  • AT1 receptor/Type-1 angiotensin II receptor in Human [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
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  • AT2 receptor in Human [GtoPdb: 35] [UniProtKB: P50052]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
FPR1/Formyl peptide receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3359] [GtoPdb: 222] [UniProtKB: P21462]
ChEMBL GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR1 F 5.41 pIC50 3858.09 nM IC50 EUbOPEN Chemogenomics Library - GPCR Dose-Respose
AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
ChEMBL Inhibition of human AT1 receptor B 7.92 pKi 12 nM Ki J Med Chem (2020) 63: 1978-1995 [PMID:32030982]
AT2 receptor in Human [GtoPdb: 35] [UniProtKB: P50052]
GtoPdb - - 9.2 pKd 0.63 nM Kd Heterogeneity of angiotensin receptor subtypes.. Medicinal Chemistry of the Renin-Angiotensin System. (1994);
Mol Pharmacol (1990) 38: 370-7 [PMID:2402226];
J Cardiovasc Pharmacol (1991) 17: 177-84 [PMID:1709220]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]