dusigitumab   Click here for help

GtoPdb Ligand ID: 7749

Synonyms: MEDI-573
Compound class: Antibody
Comment: Dusigitumab is an investigational monoclonal antibody which neutralises circulating insulin-like growth factor (IGF)-I and IGF-2. These growth factors regulate cell growth, survival, differentiation, and transformation. Antibody-mediated ligand neutralisation prevents these growth hormones from activating signalling via both IGF1R and IR-A (insulin receptor isoform A, Uniprot identifier P06213-2, RefSeq protein NP_001073285).
Peptide sequence alignment suggests that dusigitumab is antibody 7-159-1 in patent US7939637 [2].
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
9679 dusigitumab
Synonyms Click here for help
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 451
Other databases
GtoPdb PubChem SID 223366082
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Wikipedia Dusigitumab