GtoPdb Ligand ID: 7749

Synonyms: MEDI-573
Compound class: Antibody
Comment: Dusigitumab is an investigational monoclonal antibody which neutralises circulating insulin-like growth factor (IGF)-I and IGF-2. These growth factors regulate cell growth, survival, differentiation, and transformation. Antibody-mediated ligand neutralisation prevents these growth hormones from activating signalling via both IGF1R and IR-A (insulin receptor isoform A, Uniprot identifier P06213-2, RefSeq protein NP_001073285).
Peptide sequence alignment suggests that dusigitumab is antibody 7-159-1 in patent US7939637 [2].
Compound class Antibody
International Nonproprietary Names
INN number INN
9679 dusigitumab
Database Links
Specialist databases
IMGT/mAb-DB 451
Other databases
GtoPdb PubChem SID 223366082
Search PubMed clinical trials dusigitumab
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Wikipedia Dusigitumab