(-)-Epicatechin [Ligand Id: 12497] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL583912 ((-)-epi catechin, (-)-epicatechin, Epi-catechin, Epicatechin, (-)-epicatechol, Epi-catechol, Epicatechol, L-acacatechin, L-epicatechin, NSC-81161) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] | ||||||||
| ChEMBL | Inhibition of aldose reductase in rat lens homogenate | B | 4.52 | pIC50 | >30000 | nM | IC50 | J Nat Prod (2003) 66: 1191-1196 [PMID:14510595] |
| Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [UniProtKB: P37840] | ||||||||
| ChEMBL | Inhibition of human alpha-synuclein filament formation expressed in Escherichia coli BL21(DE3) cells incubated for 72 hrs by thioflavin S based fluorescence assay | B | 4.52 | pIC50 | 29900 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
| ChEMBL | Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay | B | 6.1 | pIC50 | 800 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
| BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415] | ||||||||
| ChEMBL | Binding affinity to BCL2 | B | 4 | pKi | >100000 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 19512-19517 [PMID:18040043] |
| ChEMBL | Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assay | B | 4 | pKi | >100000 | nM | Ki | Med Chem Res (2010) 19: 817-835 |
| Arginase in Leishmania amazonensis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3108635] [UniProtKB: O96394] | ||||||||
| ChEMBL | Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substrate by Dixon reciprocal plot analysis | B | 6.7 | pKi | 200 | nM | Ki | J Nat Prod (2014) 77: 392-396 [PMID:24521209] |
| ChEMBL | Inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substrate incubated for 10 mins prior to substrate addition measured after 10 mins by colorimetry | B | 5.8 | pIC50 | 1600 | nM | IC50 | J Nat Prod (2014) 77: 392-396 [PMID:24521209] |
| Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979] | ||||||||
| ChEMBL | Binding affinity to COX1 in sheep seminal vesicle | B | 4.59 | pKd | 25900 | nM | Kd | J Nat Prod (2004) 67: 1777-1782 [PMID:15568761] |
| ChEMBL | Inhibition of cyclooxygenase activity of COX1 in sheep seminal vesicle in presence of 1 mM phenol by cyclooxygenase assay | B | 4.91 | pIC50 | 12200 | nM | IC50 | J Nat Prod (2004) 67: 1777-1782 [PMID:15568761] |
| ChEMBL | Inhibition of peroxidase activity of COX1 in heep seminal vesicle by TMPD assay | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Nat Prod (2004) 67: 1777-1782 [PMID:15568761] |
| DNA polymerase beta in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4343] [GtoPdb: 3231] [UniProtKB: P06766] | ||||||||
| ChEMBL | Inhibition of lyase activity of rat DNA polymerase beta after 30 mins by deoxyribose phosphate excision assay | B | 4.73 | pIC50 | 18500 | nM | IC50 | J Nat Prod (2004) 67: 1744-1747 [PMID:15497954] |
| DNA repair protein RAD52 homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2362978] [UniProtKB: P43351] | ||||||||
| ChEMBL | Inhibition of RAD52 (unknown origin) assessed as reduction in RAD52-ssDNA interaction using Cy3-dT30-Cy5 ssDNA by FRET assay | B | 5.84 | pIC50 | 1450 | nM | IC50 | US-20180209956-A1. HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies (null) |
| fatty acid synthase/Fatty acid synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4158] [GtoPdb: 2608] [UniProtKB: P49327] | ||||||||
| ChEMBL | Inhibition of FAS | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 4738-4742 [PMID:16870425] |
| Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
| ChEMBL | Inhibition of polymerization in wild type HIV-1 RT with poly rC/dG12-18 template primer and [3H]dGTP | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 2763-2767 [PMID:11591519] |
| Nitric-oxide synthase, endothelial in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4802] [UniProtKB: P29473] | ||||||||
| ChEMBL | Activation of eNOS in BCAEC assessed as increase in nitric oxide level after 10 mins by fluorometric analysis | B | 8.7 | pEC50 | 2 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 4441-4446 [PMID:23791569] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 | F | 4.3 | pIC50 | >50000 | nM | IC50 | J Nat Prod (2006) 69: 826-828 [PMID:16724851] |
| xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989] | ||||||||
| ChEMBL | Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (1998) 61: 71-76 [PMID:9461655] |
| TAS2R39 in Human [GtoPdb: 675] [UniProtKB: P59534] | ||||||||
| GtoPdb | - | - | 3.38 | pEC50 | 417700 | nM | EC50 | Biochem Biophys Res Commun (2011) 405: 620-5 [PMID:21272567] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
