Synonyms: Fibronum | L19TNF-alpha
Compound class:
Antibody
Comment: Onfekafusp alfa (Fibromun; L19-TNF) is a trimeric homodimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF [1]. LIke bifikafusp alfa, Fibromun targets the TNF to the tumour microenvironment via L19 binding to the angiogenesis-associated isoform of fibronectin (specifically the extradomain B or EDB). Fibromun is being investigated as an immuno-oncology therapeutic. It is one of a growing number of so-called 'immunocytokines' entering clinical development.
|
Classification | |
Compound class | Antibody |
International Nonproprietary Names | |
INN number | INN |
10653 | onfekafusp alfa |
Synonyms |
Fibronum | L19TNF-alpha |
Database Links | |
GtoPdb PubChem SID | 354702230 |
Search PubMed clinical trials | onfekafusp alfa |
Search PubMed titles | onfekafusp alfa |
Search PubMed titles/abstracts | onfekafusp alfa |