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Synonyms: Daramun (bifikafusp alfa and onfekafusp alfa) | Fibronum | L19TNF-alpha | Nidlegy (bifikafusp alfa and onfekafusp alfa)
Compound class:
Antibody
Comment: Onfekafusp alfa (Fibromun; L19-TNF) is a trimeric homodimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF [1]. LIke bifikafusp alfa, Fibromun targets the TNF to the tumour microenvironment via L19 binding to the angiogenesis-associated isoform of fibronectin (specifically the extradomain B or EDB). Fibromun is being investigated as an immuno-oncology therapeutic. It is one of a growing number of so-called 'immunocytokines' entering clinical development.
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Classification  |
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| Compound class | Antibody |
| International Nonproprietary Names |
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| INN number | INN |
| 10653 | onfekafusp alfa |
| Synonyms |
| Daramun (bifikafusp alfa and onfekafusp alfa) | Fibronum | L19TNF-alpha | Nidlegy (bifikafusp alfa and onfekafusp alfa) |
| Database Links |
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| GtoPdb PubChem SID | 354702230 |
| Search PubMed clinical trials | onfekafusp alfa |
| Search PubMed titles | onfekafusp alfa |
| Search PubMed titles/abstracts | onfekafusp alfa |
