epigallocatechin-3-gallate [Ligand Id: 7002] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL297453 ((-)-Epigallocatechin Gallate, Epigalocatechin gallate)
  • 3-oxoacyl-acyl-carrier protein reductase in Plasmodium falciparum [ChEMBL: CHEMBL4513] [UniProtKB: Q965D6]
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  • 3-oxoacyl-(Acyl-carrier protein) reductase in Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2424511] [UniProtKB: Q8I2S7]
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  • 6-phosphogluconate dehydrogenase in Human [ChEMBL: CHEMBL3404] [UniProtKB: P52209]
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  • BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415]
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  • beta-secretase 1/Beta-secretase 1 in Human [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
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  • CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
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  • CB2 receptor/Cannabinoid CB2 receptor in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
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  • CpG DNA methylase in Spiroplasma monobiae [ChEMBL: CHEMBL4373] [UniProtKB: P15840]
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  • CREB binding protein/CREB-binding protein in Human [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793]
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  • dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
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  • DNA methyltransferase 1/DNA (cytosine-5)-methyltransferase 1 in Human [ChEMBL: CHEMBL1993] [GtoPdb: 2605] [UniProtKB: P26358]
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  • dual specificity tyrosine phosphorylation regulated kinase 1A in Human [GtoPdb: 2009] [UniProtKB: Q13627]
  • dual specificity tyrosine phosphorylation regulated kinase 1A/Dual specificity tyrosine-phosphorylation-regulated kinase 1A in Rat [ChEMBL: CHEMBL5508] [GtoPdb: 2009] [UniProtKB: Q63470]
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  • dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
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  • Enoyl-[acyl-carrier-protein] reductase in Escherichia coli K-12 [ChEMBL: CHEMBL1857] [UniProtKB: P0AEK4]
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  • Enoyl-acyl-carrier protein reductase in Plasmodium falciparum [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5]
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  • Glucose-6-phosphate 1-dehydrogenase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL1075249] [UniProtKB: P11412]
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  • MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
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  • lysine acetyltransferase 5/Histone acetyltransferase KAT5 in Human [ChEMBL: CHEMBL5750] [GtoPdb: 2664] [UniProtKB: Q92993]
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  • E1A binding protein p300/Histone acetyltransferase p300 in Human [ChEMBL: CHEMBL3784] [GtoPdb: 2735] [UniProtKB: Q09472]
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  • lysine acetyltransferase 2B/Histone acetyltransferase PCAF in Human [ChEMBL: CHEMBL5500] [GtoPdb: 2737] [UniProtKB: Q92831]
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  • Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
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  • elastase, neutrophil expressed/Leukocyte elastase in Human [ChEMBL: CHEMBL248] [GtoPdb: 2358] [UniProtKB: P08246]
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  • MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
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  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
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  • MMP14/Matrix metalloproteinase 14 in Human [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
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  • MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
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  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1/Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 in Human [ChEMBL: CHEMBL2288] [GtoPdb: 3171] [UniProtKB: Q13526]
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  • proteasome 20S subunit beta 5/Proteasome Macropain subunit MB1 in Human [ChEMBL: CHEMBL4662] [GtoPdb: 2406] [UniProtKB: P28074]
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  • Replicase polyprotein 1ab in Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) [ChEMBL: CHEMBL4295557] [UniProtKB: K9N7C7]
  • CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 31253139] [UniProtKB: P0DTD1]
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  • Sarcoplasmic/endoplasmic reticulum calcium ATP-ase in Rabbit [ChEMBL: CHEMBL4693] [UniProtKB: P04191]
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  • Signal transducer and activator of transcription 1-alpha/beta in Human [ChEMBL: CHEMBL6101] [UniProtKB: P42224]
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  • squalene monooxygenase/Squalene monooxygenase in Rat [ChEMBL: CHEMBL4241] [GtoPdb: 2433] [UniProtKB: P52020]
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  • Telomerase reverse transcriptase in Human [ChEMBL: CHEMBL2916] [UniProtKB: O14746]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
3-oxoacyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4513] [UniProtKB: Q965D6]
ChEMBL Inhibition of FabG B 6.52 pIC50 300 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
3-oxoacyl-(Acyl-carrier protein) reductase in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2424511] [UniProtKB: Q8I2S7]
ChEMBL Inhibition of recombinant Plasmodium falciparum 3D7 FabG using acetoacetyl-CoA as substrate after 10 mins in presence of NADPH B 6.49 pIC50 320 nM IC50 J. Med. Chem. (2013) 56: 7516-7526 [PMID:24063369]
6-phosphogluconate dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3404] [UniProtKB: P52209]
ChEMBL Inhibition of 6PGD B 6.14 pIC50 720 nM IC50 Bioorg. Med. Chem. (2008) 16: 3580-3586 [PMID:18313308]
BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415]
ChEMBL Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assay B 6.47 pKi 335 nM Ki Med Chem Res (2010) 19: 817-835
ChEMBL Binding affinity to BCL2 B 6.63 pKi 234.42 nM Ki Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 19512-19517 [PMID:18040043]
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL Inhibition of amyloid beta (1 to 42) aggregation (unknown origin) at 4:1 compound to protein concentration after 48 hrs by thioflavin T fluorescence assay B 4 pIC50 100000 nM IC50 J. Med. Chem. (2013) 56: 4135-4155 [PMID:23484434]
ChEMBL Inhibition of amyloid beta1-42 (unknown origin) aggregation assessed as amyloid fibril formation tested after 17 hrs by thioflavin T fluorescence method B 5.34 pIC50 4600 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 3108-3112 [PMID:24878198]
ChEMBL Inhibition of amyloid beta1-40 (unknown origin) aggregation B 5.52 pIC50 3000 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 3108-3112 [PMID:24878198]
ChEMBL Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation incubated at 37 degC for 16 hrs by thioflavin T fluorescence assay B 6.3 pIC50 500 nM IC50 J. Nat. Prod. (2015) 78: 1221-1230 [PMID:25978520]
beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
ChEMBL Inhibition of BACE1 using Rh-EVNLDAEFK-Quencher as substrate B 5.8 pIC50 1600 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 1408-1414 [PMID:22225636]
ChEMBL Inhibition of recombinant human BACE1 using Eu-CEVNLDAEFK-Qsy7 as substrate by HTRF assay B 6.12 pIC50 757 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 1408-1414 [PMID:22225636]
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL Displacement of [3H]-CP5594 from human recombinant CB1 receptor expressed in Chem1 cells after 90 mins by scintillation counting method B 4.47 pKi 33600 nM Ki J Med Chem (2017) 60: 9413-9436 [PMID:28654265]
ChEMBL Displacement of [3H]-CP55940 from CB1 receptor (unknown origin) B 4.47 pKi 33600 nM Ki J Nat Prod (2019) 82: 636-646 [PMID:30816712]
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
ChEMBL Displacement of [3H]-CP55940 from CB2 receptor (unknown origin) B 4.37 pKi 42800 nM Ki J Nat Prod (2019) 82: 636-646 [PMID:30816712]
CpG DNA methylase in Spiroplasma monobiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4373] [UniProtKB: P15840]
ChEMBL Competitive inhibition of Spiroplasma sp. MQ1 SssI methyltransferase using pUC18 as substrate measured for 10 mins by Dixon plot analysis B 7.55 pKi 28 nM Ki Eur. J. Med. Chem. (2012) 55: 243-254 [PMID:22854677]
CREB binding protein/CREB-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793]
ChEMBL Inhibition of recombinant GST-tagged CBP (unknown origin) using histone H4 peptide substrate assessed as reduction in NADH formation by spectrophotometric analysis B 4.3 pIC50 50000 nM IC50 J. Med. Chem. (2016) 59: 1249-1270 [PMID:26701186]
ChEMBL Inhibition of CBP (unknown origin) B 4.3 pIC50 50000 nM IC50 Eur J Med Chem (2019) 178: 259-286 [PMID:31195169]
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
ChEMBL Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 4 secs followed by substrate addition and measured after 30 mins by luminescence assay B 4.99 pIC50 10210 nM IC50 Eur J Med Chem (2018) 151: 145-157 [PMID:29609120]
DNA methyltransferase 1/DNA (cytosine-5)-methyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1993] [GtoPdb: 2605] [UniProtKB: P26358]
ChEMBL Inhibition of His6-tagged human recombinant DNMT1 expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scintillation counting method B 6.3 pIC50 500 nM IC50 J. Med. Chem. (2015) 58: 2569-2583 [PMID:25406944]
DNA repair protein RAD52 homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2362978] [UniProtKB: P43351]
ChEMBL Inhibition of RAD52 (unknown origin) assessed as effect on RAD52-mediated annealing of complementary oligonucleotides using T-28 ssDNA substrate by FRET assay B 5.17 pIC50 6700 nM IC50 US-20180209956-A1. HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies (null)
ChEMBL Inhibition of RAD52 (unknown origin) assessed as effect on RAD52-mediated annealing of complementary oligonucleotides using T-28 ssDNA substrate in presence of replication protein A by FRET assay B