epigallocatechin-3-gallate [Ligand Id: 7002] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL297453 ((-)-Epigallocatechin Gallate, Epigalocatechin gallate)
  • 3-oxoacyl-acyl-carrier protein reductase in Plasmodium falciparum [ChEMBL: CHEMBL4513] [UniProtKB: Q965D6]
  • This target only has 0 pki data point
1 CHEMBL297453_lig_chart_1 3-oxoacyl-acyl-carrier protein reductase Plasmodium falciparum
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  • 3-oxoacyl-(Acyl-carrier protein) reductase in Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2424511] [UniProtKB: Q8I2S7]
  • This target only has 0 pki data point
2 CHEMBL297453_lig_chart_2 3-oxoacyl-(Acyl-carrier protein) reductase Plasmodium falciparum 3D7
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  • 6-phosphogluconate dehydrogenase in Human [ChEMBL: CHEMBL3404] [UniProtKB: P52209]
  • This target only has 0 pki data point
3 CHEMBL297453_lig_chart_3 6-phosphogluconate dehydrogenase Human
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  • BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415]
4 CHEMBL297453_lig_chart_4 Apoptosis regulator Bcl-2 Human
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  • Beta amyloid A4 protein in Human [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
  • This target only has 0 pki data point
5 CHEMBL297453_lig_chart_5 Beta amyloid A4 protein Human
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  • beta-secretase 1/Beta-secretase 1 in Human [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
  • This target only has 0 pki data point
6 CHEMBL297453_lig_chart_6 Beta-secretase 1 Human
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  • CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
  • This target only has 1 pki data point
7 CHEMBL297453_lig_chart_7 Cannabinoid CB1 receptor Human
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  • CpG DNA methylase in Spiroplasma monobiae [ChEMBL: CHEMBL4373] [UniProtKB: P15840]
  • This target only has 1 pki data point
8 CHEMBL297453_lig_chart_8 CpG DNA methylase Spiroplasma monobiae
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  • CREB binding protein/CREB-binding protein in Human [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793]
  • This target only has 0 pki data point
9 CHEMBL297453_lig_chart_9 CREB-binding protein Human
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  • dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
  • This target only has 0 pki data point
10 CHEMBL297453_lig_chart_10 Dipeptidyl peptidase IV Human
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  • DNA methyltransferase 1/DNA (cytosine-5)-methyltransferase 1 in Human [ChEMBL: CHEMBL1993] [GtoPdb: 2605] [UniProtKB: P26358]
  • This target only has 0 pki data point
11 CHEMBL297453_lig_chart_11 DNA (cytosine-5)-methyltransferase 1 Human
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  • dual specificity tyrosine phosphorylation regulated kinase 1A in Human [GtoPdb: 2009] [UniProtKB: Q13627]
  • dual specificity tyrosine phosphorylation regulated kinase 1A/Dual specificity tyrosine-phosphorylation-regulated kinase 1A in Rat [ChEMBL: CHEMBL5508] [GtoPdb: 2009] [UniProtKB: Q63470]
  • This target only has 0 pki data point
12 CHEMBL297453_lig_chart_12 dual specificity tyrosine phosphorylation regulated kinase 1A HumanRat
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  • dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
  • This target only has 0 pki data point
13 CHEMBL297453_lig_chart_13 Dual-specificity tyrosine-phosphorylation regulated kinase 1A Human
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  • Enoyl-[acyl-carrier-protein] reductase in Escherichia coli K-12 [ChEMBL: CHEMBL1857] [UniProtKB: P0AEK4]
  • This target only has 0 pki data point
14 CHEMBL297453_lig_chart_14 Enoyl-[acyl-carrier-protein] reductase Escherichia coli K-12
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  • Enoyl-acyl-carrier protein reductase in Plasmodium falciparum [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5]
15 CHEMBL297453_lig_chart_15 Enoyl-acyl-carrier protein reductase Plasmodium falciparum
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  • Fatty acid synthase in Plasmodium falciparum [ChEMBL: CHEMBL4512] [UniProtKB: Q965D7]
  • Fatty acid synthase in Chicken [ChEMBL: CHEMBL1795136] [UniProtKB: P12276]
  • fatty acid synthase/Fatty acid synthase in Human [ChEMBL: CHEMBL4158] [GtoPdb: 2608] [UniProtKB: P49327]
  • This target only has 0 pki data point
16 CHEMBL297453_lig_chart_16 Fatty acid synthase Plasmodium falciparumChickenHuman
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  • Glucose-6-phosphate 1-dehydrogenase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL1075249] [UniProtKB: P11412]
  • This target only has 0 pki data point
17 CHEMBL297453_lig_chart_17 Glucose-6-phosphate 1-dehydrogenase Saccharomyces cerevisiae S288c
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  • MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
  • This target only has 1 pki data point
18 CHEMBL297453_lig_chart_18 Hepatocyte growth factor receptor Human
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  • lysine acetyltransferase 5/Histone acetyltransferase KAT5 in Human [ChEMBL: CHEMBL5750] [GtoPdb: 2664] [UniProtKB: Q92993]
  • This target only has 0 pki data point
19 CHEMBL297453_lig_chart_19 Histone acetyltransferase KAT5 Human
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  • E1A binding protein p300/Histone acetyltransferase p300 in Human [ChEMBL: CHEMBL3784] [GtoPdb: 2735] [UniProtKB: Q09472]
  • This target only has 0 pki data point
20 CHEMBL297453_lig_chart_20 Histone acetyltransferase p300 Human
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  • lysine acetyltransferase 2B/Histone acetyltransferase PCAF in Human [ChEMBL: CHEMBL5500] [GtoPdb: 2737] [UniProtKB: Q92831]
  • This target only has 0 pki data point
21 CHEMBL297453_lig_chart_21 Histone acetyltransferase PCAF Human
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  • Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
  • This target only has 0 pki data point
22 CHEMBL297453_lig_chart_22 Human immunodeficiency virus type 1 reverse transcriptase Human immunodeficiency virus 1
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  • elastase, neutrophil expressed/Leukocyte elastase in Human [ChEMBL: CHEMBL248] [GtoPdb: 2358] [UniProtKB: P08246]
  • This target only has 0 pki data point
23 CHEMBL297453_lig_chart_23 Leukocyte elastase Human
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  • MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
  • This target only has 0 pki data point
24 CHEMBL297453_lig_chart_24 MAP kinase-activated protein kinase 5 Human
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  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
  • This target only has 0 pki data point
25 CHEMBL297453_lig_chart_25 MAP kinase p38 alpha Human
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  • MMP14/Matrix metalloproteinase 14 in Human [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
  • This target only has 0 pki data point
26 CHEMBL297453_lig_chart_26 Matrix metalloproteinase 14 Human
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  • MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
  • This target only has 0 pki data point
27 CHEMBL297453_lig_chart_27 Matrix metalloproteinase-2 Human
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  • MMP7/Matrix metalloproteinase 7 in Human [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237]
  • This target only has 0 pki data point
28 CHEMBL297453_lig_chart_28 Matrix metalloproteinase 7 Human
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  • Microtubule-associated protein tau in Human [ChEMBL: CHEMBL1293224] [UniProtKB: P10636]
  • This target only has 0 pki data point
29 CHEMBL297453_lig_chart_29 Microtubule-associated protein tau Human
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  • Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 in Human [ChEMBL: CHEMBL2288] [UniProtKB: Q13526]
  • This target only has 0 pki data point
30 CHEMBL297453_lig_chart_30 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Human
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  • ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
  • This target only has 0 pki data point
31 CHEMBL297453_lig_chart_31 P-glycoprotein 1 Human
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  • Phosphoglycerate mutase 1 in Human [ChEMBL: CHEMBL3334418] [UniProtKB: P18669]
  • This target only has 0 pki data point
32 CHEMBL297453_lig_chart_32 Phosphoglycerate mutase 1 Human
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  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
33 CHEMBL297453_lig_chart_33 Plasmodium falciparum Plasmodium falciparum
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  • Plasmodium falciparum D6 [ChEMBL: CHEMBL2367107]
  • This target only has 0 pki data point
34 CHEMBL297453_lig_chart_34 Plasmodium falciparum D6 Plasmodium falciparum D6
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  • mPGES1/Prostaglandin E synthase in Human [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684]
  • This target only has 0 pki data point
35 CHEMBL297453_lig_chart_35 Prostaglandin E synthase Human
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  • Signal transducer and activator of transcription 1-alpha/beta in Human [ChEMBL: CHEMBL6101] [UniProtKB: P42224]
  • This target only has 0 pki data point
36 CHEMBL297453_lig_chart_36 Signal transducer and activator of transcription 1-alpha/beta Human
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  • squalene monooxygenase/Squalene monooxygenase in Rat [ChEMBL: CHEMBL4241] [GtoPdb: 2433] [UniProtKB: P52020]
  • This target only has 0 pki data point
37 CHEMBL297453_lig_chart_37 Squalene monooxygenase Rat
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  • Telomerase reverse transcriptase in Human [ChEMBL: CHEMBL2916] [UniProtKB: O14746]
  • This target only has 0 pki data point
38 CHEMBL297453_lig_chart_38 Telomerase reverse transcriptase Human
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  • transthyretin/Transthyretin in Human [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766]
  • This target only has 0 pki data point
39 CHEMBL297453_lig_chart_39 Transthyretin Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
3-oxoacyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4513] [UniProtKB: Q965D6]
ChEMBL Inhibition of FabG B 6.52 pIC50 300 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
3-oxoacyl-(Acyl-carrier protein) reductase in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2424511] [UniProtKB: Q8I2S7]
ChEMBL Inhibition of recombinant Plasmodium falciparum 3D7 FabG using acetoacetyl-CoA as substrate after 10 mins in presence of NADPH B 6.49 pIC50 320 nM IC50 J. Med. Chem. (2013) 56: 7516-7526 [PMID:24063369]
6-phosphogluconate dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3404] [UniProtKB: P52209]
ChEMBL Inhibition of 6PGD B 6.14 pIC50 720 nM IC50 Bioorg. Med. Chem. (2008) 16: 3580-3586 [PMID:18313308]
BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415]
ChEMBL Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assay B 6.47 pKi 335 nM Ki Med Chem Res (2010) 19: 817-835
ChEMBL Binding affinity to BCL2 B 6.63 pKi 234.42 nM Ki Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 19512-19517 [PMID:18040043]
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL Inhibition of amyloid beta (1 to 42) aggregation (unknown origin) at 4:1 compound to protein concentration after 48 hrs by thioflavin T fluorescence assay B 4 pIC50 100000 nM IC50 J. Med. Chem. (2013) 56: 4135-4155 [PMID:23484434]
ChEMBL Inhibition of amyloid beta1-42 (unknown origin) aggregation assessed as amyloid fibril formation tested after 17 hrs by thioflavin T fluorescence method B 5.34 pIC50 4600 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 3108-3112 [PMID:24878198]
ChEMBL Inhibition of amyloid beta1-40 (unknown origin) aggregation B 5.52 pIC50 3000 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 3108-3112 [PMID:24878198]
ChEMBL Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation incubated at 37 degC for 16 hrs by thioflavin T fluorescence assay B 6.3 pIC50 500 nM IC50 J. Nat. Prod. (2015) 78: 1221-1230 [PMID:25978520]
beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
ChEMBL Inhibition of BACE1 using Rh-EVNLDAEFK-Quencher as substrate B 5.8 pIC50 1600 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 1408-1414 [PMID:22225636]
ChEMBL Inhibition of recombinant human BACE1 using Eu-CEVNLDAEFK-Qsy7 as substrate by HTRF assay B 6.12 pIC50 757 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 1408-1414 [PMID:22225636]
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL Displacement of [3H]-CP5594 from human recombinant CB1 receptor expressed in Chem1 cells after 90 mins by scintillation counting method B 4.47 pKi 33600 nM Ki J Med Chem (2017) 60: 9413-9436 [PMID:28654265]
CpG DNA methylase in Spiroplasma monobiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4373] [UniProtKB: P15840]
ChEMBL Competitive inhibition of Spiroplasma sp. MQ1 SssI methyltransferase using pUC18 as substrate measured for 10 mins by Dixon plot analysis B 7.55 pKi 28 nM Ki Eur. J. Med. Chem. (2012) 55: 243-254 [PMID:22854677]
CREB binding protein/CREB-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793]
ChEMBL Inhibition of recombinant GST-tagged CBP (unknown origin) using histone H4 peptide substrate assessed as reduction in NADH formation by spectrophotometric analysis B 4.3 pIC50 50000 nM IC50 J. Med. Chem. (2016) 59: 1249-1270 [PMID:26701186]
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
ChEMBL Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 4 secs followed by substrate addition and measured after 30 mins by luminescence assay B 4.99 pIC50 10210 nM IC50 Eur J Med Chem (2018) 151: 145-157 [PMID:29609120]
DNA methyltransferase 1/DNA (cytosine-5)-methyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1993] [GtoPdb: 2605] [UniProtKB: P26358]
ChEMBL Inhibition of His6-tagged human recombinant DNMT1 expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scintillation counting method B 6.3 pIC50 500 nM IC50 J. Med. Chem. (2015) 58: 2569-2583 [PMID:25406944]
dual specificity tyrosine phosphorylation regulated kinase 1A in Human [GtoPdb: 2009] [UniProtKB: Q13627]
GtoPdb - - 6.48 pIC50 330 nM IC50 Brain Sci (2018) 8: [PMID:30332747]
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual specificity tyrosine-phosphorylation-regulated kinase 1A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5508] [GtoPdb: 2009] [UniProtKB: Q63470]
ChEMBL Inhibition of rat Dyrk1A using Woodtide as substrate after 40 mins by P81 membrane assay in presence of [33P]-g-ATP B 6.48 pIC50 330 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 2948-2952 [PMID:26048785]
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
ChEMBL Inhibition of GST-tagged human DYRK1A using dephosphorylated MBP as substrate after 10 mins by Kinase-Glo plus luminescent kinase assay B 4.87 pIC50 13440 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 168-171 [PMID:22154664]
GtoPdb - - 6.48 pIC50 330 nM IC50 Brain Sci (2018) 8: [PMID:30332747]
ChEMBL Inhibition of human GST-fused DYRK1A expressed in Escherichia coli using KISGRLSPIMTEQ as substrate B 6.48 pIC50 330 nM IC50 J. Med. Chem. (2013) 56: 9569-9585 [PMID:24188002]
ChEMBL Inhibition of human recombinant GST-tagged DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate after 40 mins in presence of [gamma33P-ATP] B 6.48 pIC50 330 nM IC50 J Med Chem (2018) 61: 9791-9810 [PMID:29985601]
Enoyl-[acyl-carrier-protein] reductase in Escherichia coli K-12 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1857] [UniProtKB: P0AEK4]
ChEMBL Inhibition of Escherichia coli ENR B 4.82 pIC50 15000 nM IC50 J. Med. Chem. (2007) 50: 765-775 [PMID:17263522]
Enoyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5]
ChEMBL Inhibition of Plasmodium falciparum ENR using NADH substrate B 6.73 pKi 186 nM Ki J. Med. Chem. (2007) 50: 765-775 [PMID:17263522]
ChEMBL Inhibition of Plasmodium falciparum ENR using crotonyl-CoA substrate B 7.1 pKi 79 nM Ki J. Med. Chem. (2007) 50: 765-775 [PMID:17263522]
ChEMBL Inhibition of Plasmodium falciparum ENR in presence of triclosan B 8.1 pKi 8 nM Ki J. Med. Chem. (2007) 50: 765-775 [PMID:17263522]
ChEMBL Inhibition of Plasmodium falciparum ENR B 6.6 pIC50 250 nM IC50 J. Med. Chem. (2007) 50: 765-775 [PMID:17263522]
ChEMBL Inhibition of FabI B 6.7 pIC50 200 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
Fatty acid synthase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4512] [UniProtKB: Q965D7]
ChEMBL Inhibition of FabZ B 6.4 pIC50 400 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
ChEMBL Inhibition of recombinant Plasmodium falciparum FabZ using crotonoyl-CoA as substrate after 10 mins B 7.52 pIC50 30 nM IC50 J. Med. Chem. (2013) 56: 7516-7526 [PMID:24063369]
Fatty acid synthase in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795136] [UniProtKB: P12276]
ChEMBL Inhibition of chicken liver FASN ketoreductase activity B 4 pIC50 100000 nM IC50 J. Med. Chem. (2011) 54: 5615-5638 [PMID:21726077]
ChEMBL Inhibition of chicken liver FASN B 4.28 pIC50 52000 nM IC50 J. Med. Chem. (2011) 54: 5615-5638 [PMID:21726077]
fatty acid synthase/Fatty acid synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4158] [GtoPdb: 2608] [UniProtKB: P49327]
ChEMBL Inhibition of FAS B 4.28 pIC50 51970 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 6045-6047 [PMID:20817450]
Glucose-6-phosphate 1-dehydrogenase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075249] [UniProtKB: P11412]
ChEMBL Inhibition of yeast G6PD B 6.6 pIC50 250 nM IC50 Bioorg. Med. Chem. (2008) 16: 3580-3586 [PMID:18313308]
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
ChEMBL Inhibition of MET kinase by Dixon plot analysis B 5.48 pKi 3300 nM Ki J. Med. Chem. (2009) 52: 6543-6545 [PMID:19839593]
ChEMBL Inhibition of MET kinase B 5 pIC50 10000 nM IC50 J. Med. Chem. (2009) 52: 6543-6545 [PMID:19839593]
lysine acetyltransferase 5/Histone acetyltransferase KAT5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5750] [GtoPdb: 2664] [UniProtKB: Q92993]
ChEMBL Inhibition of recombinant TIP60 (unknown origin) using histone H4 peptide substrate assessed as reduction in NADH formation by spectrophotometric analysis B 4.15 pIC50 70000 nM IC50 J. Med. Chem. (2016) 59: 1249-1270 [PMID:26701186]
E1A binding protein p300/Histone acetyltransferase p300 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3784] [GtoPdb: 2735] [UniProtKB: Q09472]
GtoPdb - - 4.52 pIC50 30000 nM IC50 Cancer Res. (2009) 69: 583-92 [PMID:19147572]
ChEMBL Inhibition of recombinant GST-tagged p300 (unknown origin) using histone H4 peptide substrate assessed as reduction in NADH formation by spectrophotometric analysis B 4.52 pIC50 30000 nM IC50 J. Med. Chem. (2016) 59: 1249-1270 [PMID:26701186]
lysine acetyltransferase 2B/Histone acetyltransferase PCAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5500] [GtoPdb: 2737] [UniProtKB: Q92831]
GtoPdb - - 4.22 pIC50 60000 nM IC50 Cancer Res. (2009) 69: 583-92 [PMID:19147572]
ChEMBL Inhibition of recombinant PCAF (unknown origin) using histone H4 peptide substrate assessed as reduction in NADH formation by spectrophotometric analysis B 4.22 pIC50 60000 nM IC50