epigallocatechin-3-gallate [Ligand Id: 7002] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL297453 ((-)-Epigallocatechin Gallate, Epigalocatechin gallate)
  • 3-oxoacyl-acyl-carrier protein reductase in Plasmodium falciparum [ChEMBL: CHEMBL4513] [UniProtKB: Q965D6]
  • This target only has 0 pki data point
  • 0
1 CHEMBL297453_lig_chart_1 3-oxoacyl-acyl-carrier protein reductase Plasmodium falciparum
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  • 3-oxoacyl-(Acyl-carrier protein) reductase in Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2424511] [UniProtKB: Q8I2S7]
  • This target only has 0 pki data point
  • 0
2 CHEMBL297453_lig_chart_2 3-oxoacyl-(Acyl-carrier protein) reductase Plasmodium falciparum 3D7
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  • 6-phosphogluconate dehydrogenase in Human [ChEMBL: CHEMBL3404] [UniProtKB: P52209]
  • This target only has 0 pki data point
  • 0
3 CHEMBL297453_lig_chart_3 6-phosphogluconate dehydrogenase Human
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  • BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415]
  • 6.55
4 CHEMBL297453_lig_chart_4 Apoptosis regulator Bcl-2 Human
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  • Beta amyloid A4 protein in Human [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
  • This target only has 0 pki data point
  • 0
5 CHEMBL297453_lig_chart_5 Beta amyloid A4 protein Human
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  • beta-secretase 1/Beta-secretase 1 in Human [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
  • This target only has 0 pki data point
  • 0
6 CHEMBL297453_lig_chart_6 Beta-secretase 1 Human
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  • CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
  • 4.47
7 CHEMBL297453_lig_chart_7 Cannabinoid CB1 receptor Human
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  • CB2 receptor/Cannabinoid CB2 receptor in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
  • This target only has 1 pki data point
  • 4.37
8 CHEMBL297453_lig_chart_8 Cannabinoid CB2 receptor Human
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  • CpG DNA methylase in Spiroplasma monobiae [ChEMBL: CHEMBL4373] [UniProtKB: P15840]
  • This target only has 1 pki data point
  • 7.55
9 CHEMBL297453_lig_chart_9 CpG DNA methylase Spiroplasma monobiae
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  • CREB binding protein/CREB-binding protein in Human [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793]
  • This target only has 0 pki data point
  • 0
10 CHEMBL297453_lig_chart_10 CREB-binding protein Human
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  • dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
  • This target only has 0 pki data point
  • 0
11 CHEMBL297453_lig_chart_11 Dipeptidyl peptidase IV Human
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  • DNA methyltransferase 1/DNA (cytosine-5)-methyltransferase 1 in Human [ChEMBL: CHEMBL1993] [GtoPdb: 2605] [UniProtKB: P26358]
  • This target only has 0 pki data point
  • 0
12 CHEMBL297453_lig_chart_12 DNA (cytosine-5)-methyltransferase 1 Human
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  • DNA repair protein RAD52 homolog in Human [ChEMBL: CHEMBL2362978] [UniProtKB: P43351]
  • This target only has 0 pki data point
  • 0
13 CHEMBL297453_lig_chart_13 DNA repair protein RAD52 homolog Human
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  • dual specificity tyrosine phosphorylation regulated kinase 1A in Human [GtoPdb: 2009] [UniProtKB: Q13627]
  • dual specificity tyrosine phosphorylation regulated kinase 1A/Dual specificity tyrosine-phosphorylation-regulated kinase 1A in Rat [ChEMBL: CHEMBL5508] [GtoPdb: 2009] [UniProtKB: Q63470]
  • This target only has 0 pki data point
  • 0
14 CHEMBL297453_lig_chart_14 dual specificity tyrosine phosphorylation regulated kinase 1A HumanRat
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  • dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
  • This target only has 0 pki data point
  • 0
15 CHEMBL297453_lig_chart_15 Dual-specificity tyrosine-phosphorylation regulated kinase 1A Human
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  • Enoyl-[acyl-carrier-protein] reductase in Escherichia coli K-12 [ChEMBL: CHEMBL1857] [UniProtKB: P0AEK4]
  • This target only has 0 pki data point
  • 0
16 CHEMBL297453_lig_chart_16 Enoyl-[acyl-carrier-protein] reductase Escherichia coli K-12
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  • Enoyl-acyl-carrier protein reductase in Plasmodium falciparum [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5]
  • 7.1
17 CHEMBL297453_lig_chart_17 Enoyl-acyl-carrier protein reductase Plasmodium falciparum
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  • Fatty acid synthase in Plasmodium falciparum [ChEMBL: CHEMBL4512] [UniProtKB: Q965D7]
  • Fatty acid synthase in Chicken [ChEMBL: CHEMBL1795136] [UniProtKB: P12276]
  • fatty acid synthase/Fatty acid synthase in Human [ChEMBL: CHEMBL4158] [GtoPdb: 2608] [UniProtKB: P49327]
  • This target only has 0 pki data point
  • 0
18 CHEMBL297453_lig_chart_18 Fatty acid synthase Plasmodium falciparumChickenHuman
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  • Genome polyprotein in Zika virus [ChEMBL: CHEMBL4523954] [UniProtKB: A0A024AXB9]
  • This target only has 0 pki data point
  • 0
19 CHEMBL297453_lig_chart_19 Genome polyprotein Zika virus
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  • Glucose-6-phosphate 1-dehydrogenase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL1075249] [UniProtKB: P11412]
  • This target only has 0 pki data point
  • 0
20 CHEMBL297453_lig_chart_20 Glucose-6-phosphate 1-dehydrogenase Saccharomyces cerevisiae S288c
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  • GroEL/GroES in Escherichia coli [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1Q7BGE6]
  • This target only has 0 pki data point
  • 0
21 CHEMBL297453_lig_chart_21 GroEL/GroES Escherichia coli
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  • MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
  • This target only has 1 pki data point
  • 5.48
22 CHEMBL297453_lig_chart_22 Hepatocyte growth factor receptor Human
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  • lysine acetyltransferase 5/Histone acetyltransferase KAT5 in Human [ChEMBL: CHEMBL5750] [GtoPdb: 2664] [UniProtKB: Q92993]
  • This target only has 0 pki data point
  • 0
23 CHEMBL297453_lig_chart_23 Histone acetyltransferase KAT5 Human
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  • E1A binding protein p300/Histone acetyltransferase p300 in Human [ChEMBL: CHEMBL3784] [GtoPdb: 2735] [UniProtKB: Q09472]
  • This target only has 0 pki data point
  • 0
24 CHEMBL297453_lig_chart_24 Histone acetyltransferase p300 Human
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  • lysine acetyltransferase 2B/Histone acetyltransferase PCAF in Human [ChEMBL: CHEMBL5500] [GtoPdb: 2737] [UniProtKB: Q92831]
  • This target only has 0 pki data point
  • 0
25 CHEMBL297453_lig_chart_25 Histone acetyltransferase PCAF Human
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26 CHEMBL297453_lig_chart_26 HSP60/HSP10 Human
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  • Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
  • This target only has 0 pki data point
  • 0
27 CHEMBL297453_lig_chart_27 Human immunodeficiency virus type 1 reverse transcriptase Human immunodeficiency virus 1
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  • elastase, neutrophil expressed/Leukocyte elastase in Human [ChEMBL: CHEMBL248] [GtoPdb: 2358] [UniProtKB: P08246]
  • This target only has 0 pki data point
  • 0
28 CHEMBL297453_lig_chart_28 Leukocyte elastase Human
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  • MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
  • This target only has 0 pki data point
  • 0
29 CHEMBL297453_lig_chart_29 MAP kinase-activated protein kinase 5 Human
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  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
  • This target only has 0 pki data point
  • 0
30 CHEMBL297453_lig_chart_30 MAP kinase p38 alpha Human
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  • MMP14/Matrix metalloproteinase 14 in Human [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
  • This target only has 0 pki data point
  • 0
31 CHEMBL297453_lig_chart_31 Matrix metalloproteinase 14 Human
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  • MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
  • This target only has 0 pki data point
  • 0
32 CHEMBL297453_lig_chart_32 Matrix metalloproteinase-2 Human
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  • MMP7/Matrix metalloproteinase 7 in Human [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237]
  • This target only has 0 pki data point
  • 0
33 CHEMBL297453_lig_chart_33 Matrix metalloproteinase 7 Human
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  • Microtubule-associated protein tau in Human [ChEMBL: CHEMBL1293224] [UniProtKB: P10636]
  • This target only has 0 pki data point
  • 0
34 CHEMBL297453_lig_chart_34 Microtubule-associated protein tau Human
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  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1/Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 in Human [ChEMBL: CHEMBL2288] [GtoPdb: 3171] [UniProtKB: Q13526]
  • This target only has 0 pki data point
  • 0
35 CHEMBL297453_lig_chart_35 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Human
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  • ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
  • This target only has 0 pki data point
  • 0
36 CHEMBL297453_lig_chart_36 P-glycoprotein 1 Human
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  • Phosphoglycerate mutase 1 in Human [ChEMBL: CHEMBL3334418] [UniProtKB: P18669]
  • This target only has 0 pki data point
  • 0
37 CHEMBL297453_lig_chart_37 Phosphoglycerate mutase 1 Human
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  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
  • 0
38 CHEMBL297453_lig_chart_38 Plasmodium falciparum Plasmodium falciparum
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  • Plasmodium falciparum D6 [ChEMBL: CHEMBL2367107]
  • This target only has 0 pki data point
  • 0
39 CHEMBL297453_lig_chart_39 Plasmodium falciparum D6 Plasmodium falciparum D6
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  • mPGES1/Prostaglandin E synthase in Human [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684]
  • This target only has 0 pki data point
  • 0
40 CHEMBL297453_lig_chart_40 Prostaglandin E synthase Human
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  • proteasome 20S subunit beta 5/Proteasome Macropain subunit MB1 in Human [ChEMBL: CHEMBL4662] [GtoPdb: 2406] [UniProtKB: P28074]
  • This target only has 0 pki data point
  • 0
41 CHEMBL297453_lig_chart_41 Proteasome Macropain subunit MB1 Human
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  • Replicase polyprotein 1ab in Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) [ChEMBL: CHEMBL4295557] [UniProtKB: K9N7C7]
  • CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 31253139] [UniProtKB: P0DTD1]
  • This target only has 0 pki data point
  • 0
42 CHEMBL297453_lig_chart_42 Replicase polyprotein 1ab Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC)Severe acute respiratory syndrome coronavirus 2
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  • Sarcoplasmic/endoplasmic reticulum calcium ATP-ase in Rabbit [ChEMBL: CHEMBL4693] [UniProtKB: P04191]
  • This target only has 0 pki data point
  • 0
43 CHEMBL297453_lig_chart_43 Sarcoplasmic/endoplasmic reticulum calcium ATP-ase Rabbit
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  • Signal transducer and activator of transcription 1-alpha/beta in Human [ChEMBL: CHEMBL6101] [UniProtKB: P42224]
  • This target only has 0 pki data point
  • 0
44 CHEMBL297453_lig_chart_44 Signal transducer and activator of transcription 1-alpha/beta Human
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  • squalene monooxygenase/Squalene monooxygenase in Rat [ChEMBL: CHEMBL4241] [GtoPdb: 2433] [UniProtKB: P52020]
  • This target only has 0 pki data point
  • 0
45 CHEMBL297453_lig_chart_45 Squalene monooxygenase Rat
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  • Telomerase reverse transcriptase in Human [ChEMBL: CHEMBL2916] [UniProtKB: O14746]
  • This target only has 0 pki data point
  • 0
46 CHEMBL297453_lig_chart_46 Telomerase reverse transcriptase Human
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  • transthyretin/Transthyretin in Human [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766]
  • This target only has 0 pki data point
  • 0
47 CHEMBL297453_lig_chart_47 Transthyretin Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
3-oxoacyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4513] [UniProtKB: Q965D6]
ChEMBL Inhibition of FabG B 6.52 pIC50 300 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
3-oxoacyl-(Acyl-carrier protein) reductase in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2424511] [UniProtKB: Q8I2S7]
ChEMBL Inhibition of recombinant Plasmodium falciparum 3D7 FabG using acetoacetyl-CoA as substrate after 10 mins in presence of NADPH B 6.49 pIC50 320 nM IC50 J. Med. Chem. (2013) 56: 7516-7526 [PMID:24063369]
6-phosphogluconate dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3404] [UniProtKB: P52209]
ChEMBL Inhibition of 6PGD B 6.14 pIC50 720 nM IC50 Bioorg. Med. Chem. (2008) 16: 3580-3586 [PMID:18313308]
BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415]
ChEMBL Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assay B 6.47 pKi 335 nM Ki Med Chem Res (2010) 19: 817-835
ChEMBL Binding affinity to BCL2 B 6.63 pKi 234.42 nM Ki Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 19512-19517 [PMID:18040043]
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL Inhibition of amyloid beta (1 to 42) aggregation (unknown origin) at 4:1 compound to protein concentration after 48 hrs by thioflavin T fluorescence assay B 4 pIC50 100000 nM IC50 J. Med. Chem. (2013) 56: 4135-4155 [PMID:23484434]
ChEMBL Inhibition of amyloid beta1-42 (unknown origin) aggregation assessed as amyloid fibril formation tested after 17 hrs by thioflavin T fluorescence method B 5.34 pIC50 4600 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 3108-3112 [PMID:24878198]
ChEMBL Inhibition of amyloid beta1-40 (unknown origin) aggregation B 5.52 pIC50 3000 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 3108-3112 [PMID:24878198]
ChEMBL Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation incubated at 37 degC for 16 hrs by thioflavin T fluorescence assay B 6.3 pIC50 500 nM IC50 J. Nat. Prod. (2015) 78: 1221-1230 [PMID:25978520]
beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
ChEMBL Inhibition of BACE1 using Rh-EVNLDAEFK-Quencher as substrate B 5.8 pIC50 1600 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 1408-1414 [PMID:22225636]
ChEMBL Inhibition of recombinant human BACE1 using Eu-CEVNLDAEFK-Qsy7 as substrate by HTRF assay B 6.12 pIC50 757 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 1408-1414 [PMID:22225636]
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL Displacement of [3H]-CP5594 from human recombinant CB1 receptor expressed in Chem1 cells after 90 mins by scintillation counting method B 4.47 pKi 33600 nM Ki J Med Chem (2017) 60: 9413-9436 [PMID:28654265]
ChEMBL Displacement of [3H]-CP55940 from CB1 receptor (unknown origin) B 4.47 pKi 33600 nM Ki J Nat Prod (2019) 82: 636-646 [PMID:30816712]
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
ChEMBL Displacement of [3H]-CP55940 from CB2 receptor (unknown origin) B 4.37 pKi 42800 nM Ki J Nat Prod (2019) 82: 636-646 [PMID:30816712]
CpG DNA methylase in Spiroplasma monobiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4373] [UniProtKB: P15840]
ChEMBL Competitive inhibition of Spiroplasma sp. MQ1 SssI methyltransferase using pUC18 as substrate measured for 10 mins by Dixon plot analysis B 7.55 pKi 28 nM Ki Eur. J. Med. Chem. (2012) 55: 243-254 [PMID:22854677]
CREB binding protein/CREB-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793]
ChEMBL Inhibition of recombinant GST-tagged CBP (unknown origin) using histone H4 peptide substrate assessed as reduction in NADH formation by spectrophotometric analysis B 4.3 pIC50 50000 nM IC50 J. Med. Chem. (2016) 59: 1249-1270 [PMID:26701186]
ChEMBL Inhibition of CBP (unknown origin) B 4.3 pIC50 50000 nM IC50 Eur J Med Chem (2019) 178: 259-286 [PMID:31195169]
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
ChEMBL Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 4 secs followed by substrate addition and measured after 30 mins by luminescence assay B 4.99 pIC50 10210 nM IC50