compound 22 [PMID: 20462760] [Ligand Id: 8205] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1084106
  • Cell division control protein 42 homolog in Human [ChEMBL: CHEMBL6088] [UniProtKB: P60953]
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  • DM1 protein kinase/Myotonin-protein kinase in Human [ChEMBL: CHEMBL5320] [GtoPdb: 1505] [UniProtKB: Q09013]
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  • protein kinase C epsilon/Protein kinase C epsilon in Human [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
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  • protein kinase N2/Protein kinase N2 in Human [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
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  • Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
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  • Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cell division control protein 42 homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6088] [UniProtKB: P60953]
ChEMBL Inhibition of CDc42 B 5.1 pIC50 >8000 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 3235-3239 [PMID:20462760]
DM1 protein kinase/Myotonin-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5320] [GtoPdb: 1505] [UniProtKB: Q09013]
ChEMBL Inhibition of DMPK B 5.1 pIC50 >8000 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 3235-3239 [PMID:20462760]
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
ChEMBL Inhibition of Prkce B 5.1 pIC50 >8000 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 3235-3239 [PMID:20462760]
protein kinase N2/Protein kinase N2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
ChEMBL Inhibition of Prkcl2 B 5.1 pIC50 >8000 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 3235-3239 [PMID:20462760]
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
ChEMBL Inhibition of ROCK1 B 7.41 pIC50 39 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 3235-3239 [PMID:20462760]
GtoPdb - - 7.41 pIC50 39 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 3235-9 [PMID:20462760]
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
GtoPdb - - 7.72 pIC50 19 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 3235-9 [PMID:20462760]
ChEMBL Inhibition of ROCK2 B 7.72 pIC50 19 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 3235-3239 [PMID:20462760]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]