[3H]A804598 [Ligand Id: 5408] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL574539 (A-804598) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| P2X7/P2X purinoceptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4805] [GtoPdb: 484] [UniProtKB: Q99572] | ||||||||
| ChEMBL | Antagonist activity against human P2X7R expressed in human 1321N1 cell membrane incubated for 1 hrs by radioligand binding assay | B | 7.96 | pIC50 | 11 | nM | IC50 | ACS Med Chem Lett (2022) 13: 1564-1567 [PMID:36262403] |
| ChEMBL | Binding affinity at human P2X7 receptor | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem (2009) 17: 4861-4865 [PMID:19540765] |
| P2X7/P2X purinoceptor 7 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5183] [GtoPdb: 484] [UniProtKB: Q9Z1M0] | ||||||||
| ChEMBL | Binding affinity at mouse P2X7 receptor | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem (2009) 17: 4861-4865 [PMID:19540765] |
| ChEMBL | Antagonist activity against mouse P2X7R expressed in human 1321N1 cell membrane incubated for 1 hrs by radioligand binding assay | B | 8.05 | pIC50 | 9 | nM | IC50 | ACS Med Chem Lett (2022) 13: 1564-1567 [PMID:36262403] |
| P2X7/P2X purinoceptor 7 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2496] [GtoPdb: 484] [UniProtKB: Q64663] | ||||||||
| ChEMBL | Binding affinity at rat P2X7 receptor | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem (2009) 17: 4861-4865 [PMID:19540765] |
| ChEMBL | Antagonist activity against rat P2X7R expressed in human 1321N1 cell membrane incubated for 1 hrs by radioligand binding assay | B | 8 | pIC50 | 10 | nM | IC50 | ACS Med Chem Lett (2022) 13: 1564-1567 [PMID:36262403] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
