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ChEMBL ligand: CHEMBL46 (A04AA01, Desmethylondansetron, EUR-1025, GR-38032, GR-38032F, NSC-757870, Ondansetron, Zofran, Zofran odt, Zuplenz) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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α2A-adrenoceptor/Alpha-2a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL327] [GtoPdb: 25] [UniProtKB: P22909] | ||||||||
ChEMBL | The binding affinity was measured on alpha-2-adrenergic receptor using [3H]- clonidine as radioligand. | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1993) 36: 3693-3699 [PMID:8246239] |
CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
ChEMBL | The binding affinity was measured on cholecystokinin type A receptor using [3H]- CCK-8 as radioligand. | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1993) 36: 3693-3699 [PMID:8246239] |
CCK2 receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553] | ||||||||
ChEMBL | The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand. | B | 6.17 | pKi | 680 | nM | Ki | J Med Chem (1993) 36: 3693-3699 [PMID:8246239] |
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] | ||||||||
ChEMBL | The binding affinity was measured on delta-opiate receptor using [3H]- dadle as radioligand. | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1993) 36: 3693-3699 [PMID:8246239] |
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] | ||||||||
ChEMBL | The binding affinity was measured on dopamine receptor D1 using [3H]- dopamine as radioligand. | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1993) 36: 3693-3699 [PMID:8246239] |
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
ChEMBL | Displacement of [3H]-raclopride from human D2L receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method | B | 5 | pKi | >10000 | nM | Ki | Eur J Med Chem (2022) 232: 114193-114193 [PMID:35176563] |
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
ChEMBL | The binding affinity was measured on dopamine receptor D2 using [3H]- spiperone as radioligand. | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1993) 36: 3693-3699 [PMID:8246239] |
ChEMBL | Binding affinity against dopamine D2 receptor in rat brain synaptic membrane using [3H]-spiperone as radioligand | B | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 619-624 [PMID:9871571] |
ChEMBL | Inhibition of the binding of radioligand [3H]spiperone to dopamine receptor D2 in rat brain synaptic membrane | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2003) 46: 702-715 [PMID:12593651] |
D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020] | ||||||||
ChEMBL | The binding affinity was measured on dopamine receptor D3 using [3H]- dopamine as radioligand. | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1993) 36: 3693-3699 [PMID:8246239] |
GABAA receptor π subunit/GABAA receptor β1 subunit/GABAA receptor δ subunit/GABAA receptor γ2 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor γ1 subunit/GABAA receptor α2 subunit/GABAA receptor α4 subunit/GABAA receptor γ3 subunit/GABAA receptor α6 subunit/GABAA receptor α1 subunit/GABAA receptor β3 subunit/GABAA receptor β2 subunit/GABAA receptor ε subunit/GABA-A receptor; anion channel in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907607] [GtoPdb: 419, 410, 416, 414, 408, 406, 413, 405, 407, 415, 409, 404, 412, 411, 417] [UniProtKB: O09028, P15431, P18506, P18508, P19969, P20236, P23574, P23576, P28471, P28473, P30191, P62813, P63079, P63138, Q91ZM7, Q9ES14] | ||||||||
ChEMBL | Displacement of [3H]- Diazepam from rat GABA-A benzodiazepine receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1993) 36: 3693-3699 [PMID:8246239] |
ChEMBL | Displacement of [3H]DH-muscimol from rat GABA-A receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1993) 36: 3693-3699 [PMID:8246239] |
ChEMBL | Non-competitive antagonist activity against Gamma-aminobutyric acid A (GABA-A) receptor | F | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2000) 43: 1427-1447 [PMID:10780899] |
GluN2C/Glutamate [NMDA] receptor subunit epsilon 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL401] [GtoPdb: 458] [UniProtKB: Q00961] | ||||||||
ChEMBL | The binding affinity was measured on NMDA receptor using [3H]- CGS-19755 as radioligand. | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1993) 36: 3693-3699 [PMID:8246239] |
glycine receptor α4 subunit (pseudogene in humans)/Glycine receptor alpha-4 chain in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3500] [GtoPdb: 426] [UniProtKB: Q61603] | ||||||||
ChEMBL | The binding affinity was measured on glycine receptor using [3H]- strychnine as radioligand. | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1993) 36: 3693-3699 [PMID:8246239] |
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of human Potassium channel HERG expressed in mammalian cells | B | 6.09 | pIC50 | 812.83 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2773-2775 [PMID:12873512] |
ChEMBL | Inhibitory concentration against potassium channel HERG | B | 6.09 | pIC50 | 812.83 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 2886-2890 [PMID:15911273] |
ChEMBL | Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique | B | 6.09 | pIC50 | 812.83 | nM | IC50 | Bioorg Med Chem (2008) 16: 6252-6260 [PMID:18448342] |
ChEMBL | Inhibition of human ERG | B | 6.09 | pIC50 | 812.83 | nM | IC50 | Eur J Med Chem (2011) 46: 618-630 [PMID:21185626] |
ChEMBL | Inhibition of human ERG expressed in HEK cells by patch clamp technique | B | 6.4 | pIC50 | 400 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6538-6541 [PMID:20889341] |
H1 receptor/Histamine H1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4701] [GtoPdb: 262] [UniProtKB: P31390] | ||||||||
ChEMBL | The binding affinity was measured on histamine H1 receptor using [3H]- mepyramine as radioligand. | B | 5 |