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Target not currently curated in GtoImmuPdb
Target id: 426
Nomenclature: glycine receptor α4 subunit (pseudogene in humans)
Family: Glycine receptors
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | - | Xq22.2 | GLRA4 | glycine receptor alpha 4 (pseudogene) | |
| Mouse | 4 | 456 | X 59.1 cM | Glra4 | glycine receptor, alpha 4 subunit | 4 |
| Rat | 4 | 456 | Xq35 | Glra4 | glycine receptor alpha 4 | |
| Previous and Unofficial Names |
| glycine receptor | glycine receptor alpha 4 |
| Database Links |
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| Alphafold | Q5JXX5 (Hs), Q61603 (Mm) |
| CATH/Gene3D | 2.70.170.10 |
| ChEMBL Target | CHEMBL3500 (Mm) |
| Ensembl Gene | ENSG00000188828 (Hs), ENSMUSG00000018595 (Mm), ENSRNOG00000002391 (Rn) |
| Entrez Gene | 441509 (Hs), 14657 (Mm), 367912 (Rn) |
| Human Protein Atlas | ENSG00000188828 (Hs) |
| KEGG Gene | hsa:441509 (Hs), mmu:14657 (Mm), rno:367912 (Rn) |
| Pharos | Q5JXX5 (Hs) |
| RefSeq Nucleotide | NM_001024452 (Hs), NM_010297 (Mm), NM_001191914 (Rn) |
| RefSeq Protein | NP_001019623 (Hs), NP_034427 (Mm), NP_001178843 (Rn) |
| UniProtKB | Q5JXX5 (Hs), Q61603 (Mm) |
| Wikipedia | GLRA4 (Hs) |
| Natural/Endogenous Ligands |
| glycine |
| Tissue Distribution
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| Tissue Distribution Comments | ||||||||
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| General Comments |
| The α4 subunit is likely to be a pseudogene in man. Full length information for the rat α4 subunit is only available as a predicted sequence. |
1. Froh M, Thurman RG, Wheeler MD. (2002) Molecular evidence for a glycine-gated chloride channel in macrophages and leukocytes. Am J Physiol Gastrointest Liver Physiol, 283 (4): G856-63. [PMID:12223345]
2. Harvey RJ, Schmieden V, Von Holst A, Laube B, Rohrer H, Betz H. (2000) Glycine receptors containing the alpha4 subunit in the embryonic sympathetic nervous system, spinal cord and male genital ridge. Eur J Neurosci, 12 (3): 994-1001. [PMID:10762330]
3. Heinze L, Harvey RJ, Haverkamp S, Wässle H. (2007) Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit. J Comp Neurol, 500 (4): 693-707. [PMID:17154252]
4. Matzenbach B, Maulet Y, Sefton L, Courtier B, Avner P, Guénet JL, Betz H. (1994) Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant. J Biol Chem, 269 (4): 2607-12. [PMID:7507926]
