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5-ht5b receptor

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Target not currently curated in GtoImmuPdb

Target id: 648

Nomenclature: 5-ht5b receptor

Family: 5-Hydroxytryptamine receptors

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor: pseudogene in man
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - 2q14.1 HTR5BP 5-hydroxytryptamine receptor 5B, pseudogene
Mouse 7 370 1 52.98 cM Htr5b 5-hydroxytryptamine (serotonin) receptor 5B
Rat 7 370 13p12 Htr5b 5-hydroxytryptamine (serotonin) receptor 5B
Gene and Protein Information Comments
The human orthologue of the mouse 5-ht5b receptor is non-functional due to interruption of the gene by stop codons.
Previous and Unofficial Names Click here for help
GPR134 | HTR5B | G protein-coupled receptor 134 | 5Ht5b | MR22 | serotonin receptor 5B | 5-hydroxytryptamine (serotonin) receptor 5B, pseudogene
Database Links Click here for help
Specialist databases
GPCRdb 5ht5b_mouse (Mm), 5ht5b_rat (Rn)
Other databases
Alphafold P31387 (Mm), P35365 (Rn)
ChEMBL Target CHEMBL2619 (Rn)
Ensembl Gene ENSG00000125631 (Hs), ENSMUSG00000050534 (Mm), ENSRNOG00000002549 (Rn)
Entrez Gene 645694 (Hs), 15564 (Mm), 79247 (Rn)
Human Protein Atlas ENSG00000125631 (Hs)
KEGG Gene hsa:645694 (Hs), mmu:15564 (Mm), rno:79247 (Rn)
RefSeq Nucleotide NG_008325 (Hs), NM_010483 (Mm), NM_024395 (Rn)
RefSeq Protein NP_077371 (Rn)
UniProtKB P31387 (Mm), P35365 (Rn)
Wikipedia HTR5BP (Hs)
Natural/Endogenous Ligands Click here for help
5-hydroxytryptamine

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Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[125I]LSD Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Mm Full agonist 9.3 pKd 1
⤷ pKd 9.3 (Kd 4.7x10-10 M) [1]
[3H]5-CT Small molecule or natural product Ligand is labelled Ligand is radioactive Mm Full agonist - - 2
⤷ [2]

References

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1. Matthes H, Boschert U, Amlaiky N, Grailhe R, Plassat JL, Muscatelli F, Mattei MG, Hen R. (1993) Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Mol Pharmacol, 43 (3): 313-9. [PMID:8450829]

2. Waeber C, Grailhe R, Yu XJ, Hen R, Moskowitz MA. (1998) Putative 5-ht5 receptors: localization in the mouse CNS and lack of effect in the inhibition of dural protein extravasation. Ann N Y Acad Sci, 861: 85-90. [PMID:9928243]

Contributors

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