methoxsalen [Ligand Id: 12457] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL416 (8-methoxsalen, 8-methoxypsoralen, 8-mop, Deltasoralen, Meladinine, Methoxsalen, Metoxalen, NSC-45923, Oxsoralen, Oxsoralen-ultra, Oxypsoralen, Puvalen, Puvasoralen-8, SM-88 COMPONENT METHOXSALEN, Uvadex, Vitpso, Xanthotoxin) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
| ChEMBL | Inhibition of AChE by spectrophotometry | B | 4.27 | pIC50 | 54000 | nM | IC50 | J Nat Prod (2001) 64: 683-685 [PMID:11374978] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) using acetylcholine iodide as substrate preincubated for 15 mins prior to substrate addition by spectrophotometric analysis | B | 6.12 | pIC50 | 760 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4248-4252 [PMID:23746477] |
| CYP1A2/Cytochrome P450 1A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177] | ||||||||
| ChEMBL | DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 7.4 | pIC50 | 40 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Monoamine oxidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397] | ||||||||
| ChEMBL | Inhibition of MAO-A activity | B | 4.07 | pIC50 | 85110 | nM | IC50 | J Med Chem (2006) 49: 1149-1156 [PMID:16451079] |
| Tyrosinase in Agaricus bisporus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3318] [UniProtKB: O42713] | ||||||||
| ChEMBL | Activation of mushroom tyrosinase using L-tyrosine as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by ELISA | B | 4.83 | pEC50 | 14800 | nM | EC50 | Bioorg Med Chem (2016) 24: 5440-5448 [PMID:27622747] |
| TAS2R20 in Human [GtoPdb: 671] [UniProtKB: P59543] | ||||||||
| GtoPdb | - | - | 4.92 | pEC50 | 12000 | nM | EC50 | Molecules (2015) 20: 18907-22 [PMID:26501253] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
