ChEMBL ligand: CHEMBL347862 (Aminooxy-Acetic Acid, Carboxymethoxylamine)
Cystathionine β-synthase/Cystathionine beta-synthase in Human [ChEMBL: CHEMBL3399911] [GtoPdb: 1443] [UniProtKB: P35520] There should be some charts here, you may need to enable JavaScript!
Cystathionine γ-lyase/Cystathionine gamma-lyase in Human [ChEMBL: CHEMBL4295745] [GtoPdb: 1444] [UniProtKB: P32929] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Cystathionine β-synthase/Cystathionine beta-synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399911] [GtoPdb: 1443] [UniProtKB: P35520]
ChEMBL	Inhibition of full-length GST-fused human CBS assessed as reduction in H2S production using 20 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition	B	5.07	pIC50	8600	nM	IC50	Medchemcomm (2018) 9: 113-120 [PMID:30108905]
GtoPdb	-	-	5.07	pIC50	8520	nM	IC50	Br J Pharmacol (2013) 169: 922-32 [PMID:23488457]
ChEMBL	Inhibition of full-length GST-fused human CBS assessed as reduction in H2S production using 2 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition	B	5.12	pIC50	7500	nM	IC50	Medchemcomm (2018) 9: 113-120 [PMID:30108905]
ChEMBL	Inhibition of full-length GST-fused human CBS using cysteine/homocysteine as substrate assessed as decrease in H2S production preincubated for 3 mins in presence of homocysteine and lead nitrate followed by cysteine addition	B	5.4	pIC50	4000	nM	IC50	Medchemcomm (2017) 8: 198-201 [PMID:30108705]
ChEMBL	Inhibition of full-length GST-fused human CBS using methylcysteine as substrate measured for 10 mins by CPM probe-based fluorescence assay	B	6	pIC50	1000	nM	IC50	Medchemcomm (2017) 8: 198-201 [PMID:30108705]
Cystathionine γ-lyase/Cystathionine gamma-lyase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295745] [GtoPdb: 1444] [UniProtKB: P32929]
ChEMBL	Inhibition of N-terminal His-tagged CSE extracted from human HepG2 cells expressed in Escherichia coli BL21 (DE3) using cysteine as substrate assessed as decrease in H2S production preincubated for 3 mins in presence of lead nitrate followed by cysteine addition	B	5.4	pIC50	4000	nM	IC50	Medchemcomm (2017) 8: 198-201 [PMID:30108705]
GtoPdb	-	-	5.96	pIC50	1090	nM	IC50	Br J Pharmacol (2013) 169: 922-32 [PMID:23488457]
ChEMBL	Inhibition of N-terminal His-tagged CSE extracted from human HepG2 cells expressed in Escherichia coli BL21 (DE3) using methylcysteine as substrate measured for 10 mins by CPM probe-based fluorescence assay	B	6.24	pIC50	570	nM	IC50	Medchemcomm (2017) 8: 198-201 [PMID:30108705]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]