aminooxyacetic acid [Ligand Id: 5136] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL347862 (Aminooxy-Acetic Acid, Carboxymethoxylamine)
  • Cystathionine β-synthase/Cystathionine beta-synthase in Human [ChEMBL: CHEMBL3399911] [GtoPdb: 1443] [UniProtKB: P35520]
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  • Cystathionine γ-lyase/Cystathionine gamma-lyase in Human [ChEMBL: CHEMBL4295745] [GtoPdb: 1444] [UniProtKB: P32929]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cystathionine β-synthase/Cystathionine beta-synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399911] [GtoPdb: 1443] [UniProtKB: P35520]
ChEMBL Inhibition of full-length GST-fused human CBS assessed as reduction in H2S production using 20 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition B 5.07 pIC50 8600 nM IC50 MedChemComm (2018) 9: 113-120
GtoPdb - - 5.07 pIC50 8520 nM IC50 Br. J. Pharmacol. (2013) 169: 922-32 [PMID:23488457]
ChEMBL Inhibition of full-length GST-fused human CBS assessed as reduction in H2S production using 2 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition B 5.12 pIC50 7500 nM IC50 MedChemComm (2018) 9: 113-120
ChEMBL Inhibition of full-length GST-fused human CBS using cysteine/homocysteine as substrate assessed as decrease in H2S production preincubated for 3 mins in presence of homocysteine and lead nitrate followed by cysteine addition B 5.4 pIC50 4000 nM IC50 MedChemComm (2017) 8: 198-201
ChEMBL Inhibition of full-length GST-fused human CBS using methylcysteine as substrate measured for 10 mins by CPM probe-based fluorescence assay B 6 pIC50 1000 nM IC50 MedChemComm (2017) 8: 198-201
Cystathionine γ-lyase/Cystathionine gamma-lyase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295745] [GtoPdb: 1444] [UniProtKB: P32929]
ChEMBL Inhibition of N-terminal His-tagged CSE extracted from human HepG2 cells expressed in Escherichia coli BL21 (DE3) using cysteine as substrate assessed as decrease in H2S production preincubated for 3 mins in presence of lead nitrate followed by cysteine addition B 5.4 pIC50 4000 nM IC50 MedChemComm (2017) 8: 198-201
GtoPdb - - 5.96 pIC50 1090 nM IC50 Br. J. Pharmacol. (2013) 169: 922-32 [PMID:23488457]
ChEMBL Inhibition of N-terminal His-tagged CSE extracted from human HepG2 cells expressed in Escherichia coli BL21 (DE3) using methylcysteine as substrate measured for 10 mins by CPM probe-based fluorescence assay B 6.24 pIC50 570 nM IC50 MedChemComm (2017) 8: 198-201

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]