aminooxyacetic acid [Ligand Id: 5136] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL347862 (Aminooxy-Acetic Acid, Carboxymethoxylamine)
  • Cystathionine β-synthase/Cystathionine beta-synthase in Human [ChEMBL: CHEMBL3399911] [GtoPdb: 1443] [UniProtKB: P35520]
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  • Cystathionine γ-lyase/Cystathionine gamma-lyase in Human [ChEMBL: CHEMBL4295745] [GtoPdb: 1444] [UniProtKB: P32929]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cystathionine β-synthase/Cystathionine beta-synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399911] [GtoPdb: 1443] [UniProtKB: P35520]
ChEMBL Inhibition of full-length GST-fused human CBS assessed as reduction in H2S production using 20 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition B 5.07 pIC50 8600 nM IC50 Medchemcomm (2018) 9: 113-120 [PMID:30108905]
GtoPdb - - 5.07 pIC50 8520 nM IC50 Br J Pharmacol (2013) 169: 922-32 [PMID:23488457]
ChEMBL Inhibition of full-length GST-fused human CBS assessed as reduction in H2S production using 2 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition B 5.12 pIC50 7500 nM IC50 Medchemcomm (2018) 9: 113-120 [PMID:30108905]
ChEMBL Inhibition of full-length GST-fused human CBS using cysteine/homocysteine as substrate assessed as decrease in H2S production preincubated for 3 mins in presence of homocysteine and lead nitrate followed by cysteine addition B 5.4 pIC50 4000 nM IC50 Medchemcomm (2017) 8: 198-201 [PMID:30108705]
ChEMBL Inhibition of full-length GST-fused human CBS using methylcysteine as substrate measured for 10 mins by CPM probe-based fluorescence assay B 6 pIC50 1000 nM IC50 Medchemcomm (2017) 8: 198-201 [PMID:30108705]
Cystathionine γ-lyase/Cystathionine gamma-lyase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295745] [GtoPdb: 1444] [UniProtKB: P32929]
ChEMBL Inhibition of N-terminal His-tagged CSE extracted from human HepG2 cells expressed in Escherichia coli BL21 (DE3) using cysteine as substrate assessed as decrease in H2S production preincubated for 3 mins in presence of lead nitrate followed by cysteine addition B 5.4 pIC50 4000 nM IC50 Medchemcomm (2017) 8: 198-201 [PMID:30108705]
GtoPdb - - 5.96 pIC50 1090 nM IC50 Br J Pharmacol (2013) 169: 922-32 [PMID:23488457]
ChEMBL Inhibition of N-terminal His-tagged CSE extracted from human HepG2 cells expressed in Escherichia coli BL21 (DE3) using methylcysteine as substrate measured for 10 mins by CPM probe-based fluorescence assay B 6.24 pIC50 570 nM IC50 Medchemcomm (2017) 8: 198-201 [PMID:30108705]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]