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ChEMBL ligand: CHEMBL347862 (Aminooxy-Acetic Acid, Carboxymethoxylamine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Cystathionine β-synthase/Cystathionine beta-synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399911] [GtoPdb: 1443] [UniProtKB: P35520] | ||||||||
ChEMBL | Inhibition of full-length GST-fused human CBS assessed as reduction in H2S production using 20 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition | B | 5.07 | pIC50 | 8600 | nM | IC50 | Medchemcomm (2018) 9: 113-120 [PMID:30108905] |
GtoPdb | - | - | 5.07 | pIC50 | 8520 | nM | IC50 | Br J Pharmacol (2013) 169: 922-32 [PMID:23488457] |
ChEMBL | Inhibition of full-length GST-fused human CBS assessed as reduction in H2S production using 2 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition | B | 5.12 | pIC50 | 7500 | nM | IC50 | Medchemcomm (2018) 9: 113-120 [PMID:30108905] |
ChEMBL | Inhibition of full-length GST-fused human CBS using cysteine/homocysteine as substrate assessed as decrease in H2S production preincubated for 3 mins in presence of homocysteine and lead nitrate followed by cysteine addition | B | 5.4 | pIC50 | 4000 | nM | IC50 | Medchemcomm (2017) 8: 198-201 [PMID:30108705] |
ChEMBL | Inhibition of full-length GST-fused human CBS using methylcysteine as substrate measured for 10 mins by CPM probe-based fluorescence assay | B | 6 | pIC50 | 1000 | nM | IC50 | Medchemcomm (2017) 8: 198-201 [PMID:30108705] |
Cystathionine γ-lyase/Cystathionine gamma-lyase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295745] [GtoPdb: 1444] [UniProtKB: P32929] | ||||||||
ChEMBL | Inhibition of N-terminal His-tagged CSE extracted from human HepG2 cells expressed in Escherichia coli BL21 (DE3) using cysteine as substrate assessed as decrease in H2S production preincubated for 3 mins in presence of lead nitrate followed by cysteine addition | B | 5.4 | pIC50 | 4000 | nM | IC50 | Medchemcomm (2017) 8: 198-201 [PMID:30108705] |
GtoPdb | - | - | 5.96 | pIC50 | 1090 | nM | IC50 | Br J Pharmacol (2013) 169: 922-32 [PMID:23488457] |
ChEMBL | Inhibition of N-terminal His-tagged CSE extracted from human HepG2 cells expressed in Escherichia coli BL21 (DE3) using methylcysteine as substrate measured for 10 mins by CPM probe-based fluorescence assay | B | 6.24 | pIC50 | 570 | nM | IC50 | Medchemcomm (2017) 8: 198-201 [PMID:30108705] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]