ChEMBL ligand: CHEMBL347862 (Aminooxy-Acetic Acid, Carboxymethoxylamine)
Cystathionine β-synthase/Cystathionine beta-synthase in Human [ChEMBL: CHEMBL3399911] [GtoPdb: 1443] [UniProtKB: P35520] There should be some charts here, you may need to enable JavaScript!
Cystathionine γ-lyase/Cystathionine gamma-lyase in Human [ChEMBL: CHEMBL4295745] [GtoPdb: 1444] [UniProtKB: P32929] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Cystathionine β-synthase/Cystathionine beta-synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399911] [GtoPdb: 1443] [UniProtKB: P35520]
ChEMBL	Inhibition of full-length GST-fused human CBS assessed as reduction in H2S production using 20 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition	B	5.07	pIC50	8600	nM	IC50	MedChemComm (2018) 9: 113-120
GtoPdb	-	-	5.07	pIC50	8520	nM	IC50	Br J Pharmacol (2013) 169: 922-32 [PMID:23488457]
ChEMBL	Inhibition of full-length GST-fused human CBS assessed as reduction in H2S production using 2 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition	B	5.12	pIC50	7500	nM	IC50	MedChemComm (2018) 9: 113-120
ChEMBL	Inhibition of full-length GST-fused human CBS using cysteine/homocysteine as substrate assessed as decrease in H2S production preincubated for 3 mins in presence of homocysteine and lead nitrate followed by cysteine addition	B	5.4	pIC50	4000	nM	IC50	MedChemComm (2017) 8: 198-201
ChEMBL	Inhibition of full-length GST-fused human CBS using methylcysteine as substrate measured for 10 mins by CPM probe-based fluorescence assay	B	6	pIC50	1000	nM	IC50	MedChemComm (2017) 8: 198-201
Cystathionine γ-lyase/Cystathionine gamma-lyase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295745] [GtoPdb: 1444] [UniProtKB: P32929]
ChEMBL	Inhibition of N-terminal His-tagged CSE extracted from human HepG2 cells expressed in Escherichia coli BL21 (DE3) using cysteine as substrate assessed as decrease in H2S production preincubated for 3 mins in presence of lead nitrate followed by cysteine addition	B	5.4	pIC50	4000	nM	IC50	MedChemComm (2017) 8: 198-201
GtoPdb	-	-	5.96	pIC50	1090	nM	IC50	Br J Pharmacol (2013) 169: 922-32 [PMID:23488457]
ChEMBL	Inhibition of N-terminal His-tagged CSE extracted from human HepG2 cells expressed in Escherichia coli BL21 (DE3) using methylcysteine as substrate measured for 10 mins by CPM probe-based fluorescence assay	B	6.24	pIC50	570	nM	IC50	MedChemComm (2017) 8: 198-201

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]