aminooxyacetic acid [Ligand Id: 5136] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL347862 (Aminooxy-Acetic Acid, Carboxymethoxylamine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cystathionine β-synthase/Cystathionine beta-synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399911] [GtoPdb: 1443] [UniProtKB: P35520] | ||||||||
| ChEMBL | Inhibition of full-length GST-fused human CBS assessed as reduction in H2S production using 20 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition | B | 5.07 | pIC50 | 8600 | nM | IC50 | Medchemcomm (2018) 9: 113-120 [PMID:30108905] |
| GtoPdb | - | - | 5.07 | pIC50 | 8520 | nM | IC50 | Br J Pharmacol (2013) 169: 922-32 [PMID:23488457] |
| ChEMBL | Inhibition of full-length GST-fused human CBS assessed as reduction in H2S production using 2 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition | B | 5.12 | pIC50 | 7500 | nM | IC50 | Medchemcomm (2018) 9: 113-120 [PMID:30108905] |
| ChEMBL | Inhibition of full-length GST-fused human CBS using cysteine/homocysteine as substrate assessed as decrease in H2S production preincubated for 3 mins in presence of homocysteine and lead nitrate followed by cysteine addition | B | 5.4 | pIC50 | 4000 | nM | IC50 | Medchemcomm (2017) 8: 198-201 [PMID:30108705] |
| ChEMBL | Inhibition of full-length GST-fused human CBS using methylcysteine as substrate measured for 10 mins by CPM probe-based fluorescence assay | B | 6 | pIC50 | 1000 | nM | IC50 | Medchemcomm (2017) 8: 198-201 [PMID:30108705] |
| Cystathionine γ-lyase/Cystathionine gamma-lyase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295745] [GtoPdb: 1444] [UniProtKB: P32929] | ||||||||
| ChEMBL | Inhibition of N-terminal His-tagged CSE extracted from human HepG2 cells expressed in Escherichia coli BL21 (DE3) using cysteine as substrate assessed as decrease in H2S production preincubated for 3 mins in presence of lead nitrate followed by cysteine addition | B | 5.4 | pIC50 | 4000 | nM | IC50 | Medchemcomm (2017) 8: 198-201 [PMID:30108705] |
| GtoPdb | - | - | 5.96 | pIC50 | 1090 | nM | IC50 | Br J Pharmacol (2013) 169: 922-32 [PMID:23488457] |
| ChEMBL | Inhibition of N-terminal His-tagged CSE extracted from human HepG2 cells expressed in Escherichia coli BL21 (DE3) using methylcysteine as substrate measured for 10 mins by CPM probe-based fluorescence assay | B | 6.24 | pIC50 | 570 | nM | IC50 | Medchemcomm (2017) 8: 198-201 [PMID:30108705] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
