magrolimab   Click here for help

GtoPdb Ligand ID: 12652

Synonyms: Hu5F9-G4
Immunopharmacology Ligand
Compound class: Antibody
Comment: Magrolimab (Hu5F9-G4) is a clinical lead, humanized monoclonal antibody, that binds to and blocks the function of cluster of differentiation 47 (CD47), a 'don't-eat-me' signal that is overexpressed by some cancer cells [1]. CD47-blockade disrupts the CD47-SIRPα anti-phagocytic checkpoint, which induces an immunostimulating effect that promotes macrophage-mediated phagocytosis of tumour cells [2].
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Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
10999 magrolimab
Synonyms Click here for help
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 916
Other databases
GtoPdb PubChem SID 483123200
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