compound 5g [PMID: 21571530] [Ligand Id: 5514] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2153581 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| oxoglutarate receptor/2-oxoglutarate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2150840] [GtoPdb: 162] [UniProtKB: Q96P68] | ||||||||
| ChEMBL | Antagonist activity at human GPR99 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level at by FLIPR assay | F | 4.52 | pIC50 | >30000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 3596-3602 [PMID:21571530] |
| succinate receptor/Succinate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2150838] [GtoPdb: 166] [UniProtKB: Q9BXA5] | ||||||||
| ChEMBL | Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay | F | 7.46 | pIC50 | 35 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 3596-3602 [PMID:21571530] |
| GtoPdb | - | - | 7.46 | pIC50 | 35 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 3596-602 [PMID:21571530] |
| succinate receptor/Succinate receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2150839] [GtoPdb: 166] [UniProtKB: Q6IYF9] | ||||||||
| ChEMBL | Antagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay | F | 6.87 | pIC50 | 135 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 3596-3602 [PMID:21571530] |
| GtoPdb | - | - | 6.87 | pIC50 | 135 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 3596-602 [PMID:21571530] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
