abicipar pegol   Click here for help

GtoPdb Ligand ID: 8371

Synonyms: AGN-150998 | MP0112
Comment: Abicipar pegol is a VEGFA targeting protein conjugate generated using DARPin® technology [1,3]. The INN record for this construct describes it as a 'pegylated composite protein for clinical applications (CPCA)'. The amino acid sequence for the protein component is provided here. Structurally, the conjugate contains glycyl-seryl-ankyrin repeats (3-35, 36-68, 69-101, 102-123) with a short linker (127-134) and a cysteine di-sulphide bond (1-135), conjugated via a maleimide group linker (thioether bond to C135) to a single linear methoxy polyethylene glycol 20 (mPEG20). DARPins are protein therapeutics that are being developed as an alternative to antigen receptors (antibodies).
Classification Click here for help
Compound class Peptide or derivative
International Nonproprietary Names Click here for help
INN number INN
9627 abicipar pegol
Synonyms Click here for help
AGN-150998 | MP0112
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 477
Reactome Drug Reactome logo R-ALL-9679474
Reactome Reaction Reactome logo R-HSA-9679477
Other databases
GtoPdb PubChem SID 252166583
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