ilginatinib

Ligand id: 7839

Name: ilginatinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 80.55
Molecular weight 389.18
XLogP 4.14
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
-N-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methylpyrazol-4-yl)-2-N-pyrazin-2-ylpyridine-2,6-diamine
International Nonproprietary Names
INN number INN
10731 ilginatinib
Synonyms
NS-018 | NS018
Comments
Ilginatinib (NS-018) is a potent and highly selective JAK2 inhibitor. It has an ATP-competitive mode of action. The chemical structure shown here was rendered from the chemical name provided in [1]. The inhibits some Src family kinases in addition to JAK2 [2].
Database Links
GtoPdb PubChem SID 223366170
PubChem CID 46866319
Search Google for chemical match using the InChIKey UQTPDWDAYHAZNT-AWEZNQCLSA-N
Search Google for chemicals with the same backbone UQTPDWDAYHAZNT
Search PubMed clinical trials ilginatinib
Search PubMed titles ilginatinib
Search PubMed titles/abstracts ilginatinib
Search UniChem for chemical match using the InChIKey UQTPDWDAYHAZNT-AWEZNQCLSA-N
Search UniChem for chemicals with the same backbone UQTPDWDAYHAZNT