ilginatinib

Ligand id: 7839

Name: ilginatinib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 80.55
Molecular weight 389.18
XLogP 4.14
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Nakaya Y, Shide K, Naito H, Niwa T, Horio T, Miyake J, Shimoda K. (2014)
Effect of NS-018, a selective JAK2V617F inhibitor, in a murine model of myelofibrosis.
Blood Cancer J, 4: e174. [PMID:24413068]
2. Nakaya Y, Shide K, Niwa T, Homan J, Sugahara S, Horio T, Kuramoto K, Kotera T, Shibayama H, Hori K et al.. (2011)
Efficacy of NS-018, a potent and selective JAK2/Src inhibitor, in primary cells and mouse models of myeloproliferative neoplasms.
Blood Cancer J, 1 (7): e29. [PMID:22829185]
3. Verstovsek S, Talpaz M, Ritchie E, Wadleigh M, Odenike O, Jamieson C, Stein B, Uno T, Mesa RA. (2017)
A phase I, open-label, dose-escalation, multicenter study of the JAK2 inhibitor NS-018 in patients with myelofibrosis.
Leukemia, 31 (2): 393-402. [PMID:27479177]