forskolin [Ligand Id: 5190] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL52606 (Boforsin, Colforsin, Forskolin, HL 362, HL-362, L 75 1362B, L-751362B, L-75-1362B, NSC-357088, NSC-375489)
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  • adenylyl cyclase 2/Adenylate cyclase type II in Rat [ChEMBL: CHEMBL2958] [GtoPdb: 1279] [UniProtKB: P26769]
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  • adenylyl cyclase 8/Adenylate cyclase type VIII in Human [ChEMBL: CHEMBL2960] [GtoPdb: 1285] [UniProtKB: P40145]
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  • adenylyl cyclase 1/Brain adenylate cyclase 1 in Human [ChEMBL: CHEMBL2899] [GtoPdb: 1278] [UniProtKB: Q08828]
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  • Glucose transporter 1/Glucose transporter in Human [ChEMBL: CHEMBL2535] [GtoPdb: 875] [UniProtKB: P11166]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Adenylate cyclase type I in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3549] [UniProtKB: P19754]
ChEMBL Displacement of [125I]6-IHPP-Fsk from adenylate cyclase of bovine brain membrane B 7.54 pKd 29 nM Kd J. Med. Chem. (1991) 34: 3204-3212 [PMID:1956039]
adenylyl cyclase 2/Adenylate cyclase type II in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2958] [GtoPdb: 1279] [UniProtKB: P26769]
ChEMBL Ability to activate the conversion of [32P] ATP to [32P]-cyclic AMP F 5.7 pEC50 <2000 nM EC50 J. Med. Chem. (1996) 39: 2745-2752 [PMID:8709105]
adenylyl cyclase 8/Adenylate cyclase type VIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2960] [GtoPdb: 1285] [UniProtKB: P40145]
ChEMBL Agonist activity at recombinant human AC8 expressed in human HEK293 cells assessed as fold increase in cAMP level by LANCE Ultra cAMP Detection kit method B 7.03 pEC50 93.7 nM EC50 Bioorg Med Chem Lett (2020) 30: 126823-126823 [PMID:31776060]
adenylyl cyclase 1/Brain adenylate cyclase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2899] [GtoPdb: 1278] [UniProtKB: Q08828]
ChEMBL Inhibition of [125 I]6-IHPP-forskolin binding to Adenylate cyclase 1 B 6.82 pIC50 <150 nM IC50 J. Med. Chem. (1996) 39: 2745-2752 [PMID:8709105]
ChEMBL Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1 B 7.39 pIC50 41 nM IC50 J. Med. Chem. (1996) 39: 2745-2752 [PMID:8709105]
ChEMBL Conversion of [32P] ATP to [32P]-cyclic AMP mediated by adenylate cyclase 1 F 6.3 pEC50 500 nM EC50 J. Med. Chem. (1996) 39: 2745-2752 [PMID:8709105]
Glucose transporter 1/Glucose transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2535] [GtoPdb: 875] [UniProtKB: P11166]
ChEMBL Inhibition of [125I]7-IHPP-Fsk binding to glucose transporter of human erythrocyte membrane B 5.3 pKd 5000 nM Kd J. Med. Chem. (1991) 34: 3204-3212 [PMID:1956039]
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells F 4.1 pIC50 80200 nM IC50 Biochem. Biophys. Res. Commun. (2001) 289: 580-585 [PMID:11716514]
RXFP1/Relaxin receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293316] [GtoPdb: 351] [UniProtKB: Q9HBX9]
ChEMBL Agonist activity at human RXFP1 expressed in HEK293 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay F 7.33 pEC50 47 nM EC50 Eur J Med Chem (2018) 156: 79-92 [PMID:30006176]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]