teglicar [Ligand Id: 12976] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL1231506 (Teglicar) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| carnitine palmitoyltransferase 1A/Carnitine O-palmitoyltransferase 1, liver isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293194] [GtoPdb: 3249] [UniProtKB: P50416] | ||||||||
| ChEMBL | Inhibition of human CPT1A | B | 5.98 | pIC50 | 1050 | nM | IC50 | J Med Chem (2011) 54: 3109-3152 [PMID:21504156] |
| carnitine palmitoyltransferase 1A in Rat [GtoPdb: 3249] [UniProtKB: P97780] | ||||||||
| GtoPdb | Measuring the incorporation of [14C]-palmitoyl residue on carnitine in intact fresh liver mithocondria from male Sprague-Dawley rats | - | 5.96 | pIC50 | 1100 | nM | IC50 | Jourmal of Medicinal Chemistry (2003) 46: 303–309 |
| carnitine palmitoyltransferase 1B/Carnitine O-palmitoyltransferase 1, muscle isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2216739] [GtoPdb: 3250] [UniProtKB: Q92523] | ||||||||
| ChEMBL | Inhibition of human CPT1B | B | 5.27 | pIC50 | 5400 | nM | IC50 | J Med Chem (2011) 54: 3109-3152 [PMID:21504156] |
| carnitine palmitoyltransferase 1B in Rat [GtoPdb: 3250] [UniProtKB: CPT1B_RAT] | ||||||||
| GtoPdb | Measuring the incorporation of [14C]-palmitoyl residue on carnitine in intact fresh heart mithocondria from male Sprague-Dawley rats | - | 4.36 | pIC50 | 43400 | nM | IC50 | Jourmal of Medicinal Chemistry (2003) 46: 303–309 |
| Carnitine palmitoyltransferase 1A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3858] [UniProtKB: P32198] | ||||||||
| ChEMBL | Inhibition of [14C]palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria | B | 4.23 | pIC50 | 58800 | nM | IC50 | J Med Chem (2003) 46: 303-309 [PMID:12519067] |
| Carnitine palmitoyltransferase 1B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3216] [UniProtKB: Q63704] | ||||||||
| ChEMBL | Maximal inhibition of rat CPT1A | B | 5.84 | pIC50 | 1450 | nM | IC50 | J Med Chem (2011) 54: 3109-3152 [PMID:21504156] |
| carnitine palmitoyltransferase 2/Carnitine palmitoyltransferase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3238] [GtoPdb: 3252] [UniProtKB: P23786] | ||||||||
| ChEMBL | Inhibition of human CPT2 | B | 6.8 | pIC50 | 160 | nM | IC50 | J Med Chem (2011) 54: 3109-3152 [PMID:21504156] |
| carnitine palmitoyltransferase 2/Carnitine palmitoyltransferase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4037] [GtoPdb: 3252] [UniProtKB: P18886] | ||||||||
| ChEMBL | Inhibition of rat CPT2 | B | 6.42 | pIC50 | 380 | nM | IC50 | J Med Chem (2011) 54: 3109-3152 [PMID:21504156] |
| GtoPdb | - | - | 6.62 | pIC50 | 240 | nM | IC50 | Structure (2006) 14: 713-23 [PMID:16615913] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
