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carnitine palmitoyltransferase 1A

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Target not currently curated in GtoImmuPdb

Target id: 3249

Nomenclature: carnitine palmitoyltransferase 1A

Family: Carnitine palmitoyltransferases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 773 11q13.3 CPT1A carnitine palmitoyltransferase 1A
Mouse 2 773 19 A; 19 3.08 cM Cpt1a carnitine palmitoyltransferase 1a, liver
Rat 2 773 1q42 Cpt1a carnitine palmitoyltransferase 1A
Previous and Unofficial Names Click here for help
carnitine O-palmitoyltransferase 1A | L-CPT-1 | Carnitine O-palmitoyltransferase 1, liver isoform
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction Click here for help
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
teglicar Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Rn Inhibition 6.0 pIC50 2
pIC50 6.0 (IC50 1.1x10-6 M) [2]
Description: Measuring the incorporation of [14C]-palmitoyl residue on carnitine in intact fresh liver mithocondria from male Sprague-Dawley rats
etomoxir Small molecule or natural product Rn Inhibition 5.7 pIC50 1
pIC50 5.7 (IC50 2x10-6 M) [1]
Description: Determined by evaluating inhibition of fatty acid synthesis in rat hepatocytes (which express CPT1A isoform but not CPT1B or 1C)


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1. Ceccarelli SM, Chomienne O, Gubler M, Arduini A. (2011) Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. J Med Chem, 54 (9): 3109-52. [PMID:21504156]

2. Giannessi F, Pessotto P, Tassoni E, Chiodi P, Conti R, De Angelis F, Dell'Uomo N, Catini R, Deias R, Tinti MO et al.. (2003) Discovery of a Long-Chain Carbamoyl Aminocarnitine Derivative, a Reversible Carnitine Palmitoyltransferase Inhibitor with Antiketotic and Antidiabetic Activity. Jourmal of Medicinal Chemistry, 46 (2): 303–309. DOI: 10.1021/jm020979u

How to cite this page

Carnitine palmitoyltransferases: carnitine palmitoyltransferase 1A. Last modified on 06/02/2024. Accessed on 13/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,