Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	2	773	11q13.3	CPT1A	carnitine palmitoyltransferase 1A
Mouse	2	773	19 A; 19 3.08 cM	Cpt1a	carnitine palmitoyltransferase 1a, liver
Rat	2	773	1q42	Cpt1a	carnitine palmitoyltransferase 1A

Previous and Unofficial Names

carnitine O-palmitoyltransferase 1A | L-CPT-1 | Carnitine O-palmitoyltransferase 1, liver isoform

Database Links
Alphafold	P50416 (Hs), O35288 (Mm), P97780 (Rn)
BRENDA	3.2.1.21
ChEMBL Target	CHEMBL1293194 (Hs), CHEMBL3858 (Rn)
Ensembl Gene	ENSG00000110090 (Hs), ENSMUSG00000024900 (Mm), ENSRNOG00000014254 (Rn)
Entrez Gene	1374 (Hs), 12894 (Mm), 25757 (Rn)
Human Protein Atlas	ENSG00000110090 (Hs)
KEGG Enzyme	3.2.1.21
KEGG Gene	hsa:1374 (Hs), mmu:12894 (Mm), rno:25757 (Rn)
OMIM	600528 (Hs)
Pharos	P50416 (Hs)
UniProtKB	P50416 (Hs), O35288 (Mm), P97780 (Rn)
Wikipedia	CPT1A (Hs)

Enzyme Reaction
EC Number: 3.2.1.21

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference teglicar Rn Inhibition 6.0 pIC50 2 ⤷ pIC50 6.0 (IC50 1.1x10-6 M) [2] Description: Measuring the incorporation of [14C]-palmitoyl residue on carnitine in intact fresh liver mithocondria from male Sprague-Dawley rats etomoxir Rn Inhibition 5.7 pIC50 1 ⤷ pIC50 5.7 (IC50 2x10-6 M) [1] Description: Determined by evaluating inhibition of fatty acid synthesis in rat hepatocytes (which express CPT1A isoform but not CPT1B or 1C)