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carnitine palmitoyltransferase 1A

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Target not currently curated in GtoImmuPdb

Target id: 3249

Nomenclature: carnitine palmitoyltransferase 1A

Family: Carnitine palmitoyltransferases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 773 11q13.3 CPT1A carnitine palmitoyltransferase 1A
Mouse 2 773 19 A; 19 3.08 cM Cpt1a carnitine palmitoyltransferase 1a, liver
Rat 2 773 1q42 Cpt1a carnitine palmitoyltransferase 1A
Previous and Unofficial Names Click here for help
carnitine O-palmitoyltransferase 1A | L-CPT-1 | Carnitine O-palmitoyltransferase 1, liver isoform
Database Links Click here for help
Alphafold P50416 (Hs), O35288 (Mm), P97780 (Rn)
BRENDA 3.2.1.21
ChEMBL Target CHEMBL1293194 (Hs), CHEMBL3858 (Rn)
Ensembl Gene ENSG00000110090 (Hs), ENSMUSG00000024900 (Mm), ENSRNOG00000014254 (Rn)
Entrez Gene 1374 (Hs), 12894 (Mm), 25757 (Rn)
Human Protein Atlas ENSG00000110090 (Hs)
KEGG Enzyme 3.2.1.21
KEGG Gene hsa:1374 (Hs), mmu:12894 (Mm), rno:25757 (Rn)
OMIM 600528 (Hs)
Pharos P50416 (Hs)
UniProtKB P50416 (Hs), O35288 (Mm), P97780 (Rn)
Wikipedia CPT1A (Hs)
Enzyme Reaction Click here for help
EC Number: 3.2.1.21

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
teglicar Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Rn Inhibition 6.0 pIC50 2
⤷ pIC50 6.0 (IC50 1.1x10-6 M) [2]
Description: Measuring the incorporation of [14C]-palmitoyl residue on carnitine in intact fresh liver mithocondria from male Sprague-Dawley rats
etomoxir Small molecule or natural product Rn Inhibition 5.7 pIC50 1
⤷ pIC50 5.7 (IC50 2x10-6 M) [1]
Description: Determined by evaluating inhibition of fatty acid synthesis in rat hepatocytes (which express CPT1A isoform but not CPT1B or 1C)

References

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1. Ceccarelli SM, Chomienne O, Gubler M, Arduini A. (2011) Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. J Med Chem, 54 (9): 3109-52. [PMID:21504156]

2. Giannessi F, Pessotto P, Tassoni E, Chiodi P, Conti R, De Angelis F, Dell'Uomo N, Catini R, Deias R, Tinti MO et al.. (2003) Discovery of a Long-Chain Carbamoyl Aminocarnitine Derivative, a Reversible Carnitine Palmitoyltransferase Inhibitor with Antiketotic and Antidiabetic Activity. Jourmal of Medicinal Chemistry, 46 (2): 303–309. DOI: 10.1021/jm020979u

How to cite this page

Carnitine palmitoyltransferases: carnitine palmitoyltransferase 1A. Last modified on 06/02/2024. Accessed on 29/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3249.