GtoPdb Ligand ID: 5017

Synonyms: Constella® | Linzess® | MM-416775
linaclotide is an approved drug (FDA and EMA (2012))
Comment: Linaclotide represents a first-in-class, oral guanylate cyclase 2C activator [2]. It is a synthetic analogue of pathological heat-stable bacterial enterotoxins, and retains the same intrachain disulfide bond structure essential for biological activity.
Marketed formulations contain linaclotide acetate (PubChem CID 16158207). See also plecanatide, the second approved GC-C activator.
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: linactolide

Compound class Peptide or derivative
Approved drug? Yes (FDA and EMA (2012))
International Nonproprietary Names
INN number INN
8802 linaclotide
Constella® | Linzess® | MM-416775
Database Links
CAS Registry No. 851199-59-2 (source: Scifinder)
DrugBank Ligand DB08890
GtoPdb PubChem SID 178101714
PubChem CID 16158208
Search PubMed clinical trials linaclotide
Search PubMed titles linaclotide
Search PubMed titles/abstracts linaclotide
Wikipedia Linaclotide