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Natriuretic peptide receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Natriuretic peptide receptors (NPRs, provisional nomenclature) are a family of homodimeric, catalytic receptors with a single TM domain and guanylyl cyclase (EC activity on the intracellular domain of the protein sequence. Isoforms are activated by the peptide hormones atrial natriuretic peptide (NPPA, P01160), brain natriuretic peptide (NPPB, P16860) and C-type natriuretic peptide (NPPC, P23582). Another family member is GC-C, the receptor for guanylin (GUCA2A, Q02747) and uroguanylin (GUCA2B, Q16661). Family members have conserved ligand-binding, catalytic (guanylyl cyclase) and regulatory domains with the exception of NPR-C which has an extracellular binding domain homologous to that of other NPRs, but with a truncated intracellular domain which appears to couple, via the Gi/o family of G proteins, to activation of phospholipase C, inwardly-rectifying potassium channels and inhibition of adenylyl cyclase activity [16].


GC-A (Guanylyl cyclase-A) C Show summary » More detailed page

GC-B (Guanylyl cyclase-B) C Show summary » More detailed page

GC-C (Guanylyl cyclase-C) C Show summary » More detailed page

NPR-C (natriuretic peptide receptor 3) C Show summary » More detailed page


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

John C. Burnett, Jr., John Garthwaite, Adrian J. Hobbs, Doris Koesling, Michaela Kuhn, Lincoln R. Potter, Michael Russwurm, Harald H.H.W. Schmidt, Johannes-Peter Stasch, Scott A. Waldman. Natriuretic peptide receptor family. Accessed on 19/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Catalytic receptors. Br J Pharmacol. 174 Suppl 1: S225-S271.