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Receptor guanylyl cyclase (RGC) family C

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The mammalian genome encodes transmembrane and soluble receptor guanylyl cyclases, both of which have enzyme activities which convert guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP).

Subfamilies

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The polysaccharide obtained from fermentation of Aureobasidium species, HS-142-1, acts as an antagonist at both GC-A and GC-B receptors [4]. GC-D and GC-G have been reported to be activated intracellularly by guanylyl cyclase-activating protein 1 (GUCA1A, P43080) and guanylyl cyclase-activating protein 2 (GUCA1B, Q9UMX6). GC-D and GC-G may be activated by atmospheric levels of CO2 through the formation of intracellular bicarbonate ions [2-3]. GC-G may be activated at cooler temperatures (20-25°C) through apparent stabilisation of the dimer [1].

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How to cite this family page

Database page citation:

Receptor guanylyl cyclase (RGC) family. Accessed on 21/07/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1022.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Catalytic receptors. Br J Pharmacol. 174 Suppl 1: S225-S271.